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WeightNameValue
1000 Titel
  • Kynurenic Acid: The Janus-Faced Role of an Immunomodulatory Tryptophan Metabolite and Its Link to Pathological Conditions
1000 Autor/in
  1. Wirthgen, Elisa |
  2. Hoeflich, Andreas |
  3. Rebl, Alexander |
  4. Günther, Juliane |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-01-10
1000 Erschienen in
1000 Quellenangabe
  • 8:1957
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fimmu.2017.01957 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770815/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Tryptophan metabolites are known to participate in the regulation of many cells of the immune system and are involved in various immune-mediated diseases and disorders. Kynurenic acid (KYNA) is a product of one branch of the kynurenine pathway of tryptophan metabolism. The influence of KYNA on important neurophysiological and neuropathological processes has been comprehensively documented. In recent years, the link of KYNA to the immune system, inflammation, and cancer has become more apparent. Given this connection, the anti-inflammatory and immunosuppressive functions of KYNA are of particular interest. These characteristics might allow KYNA to act as a “double-edged sword.” The metabolite contributes to both the resolution of inflammation and the establishment of an immunosuppressive environment, which, for instance, allows for tumor immune escape. Our review provides a comprehensive update of the significant biological functions of KYNA and focuses on its immunomodulatory properties by signaling via G-protein-coupled receptor 35 (GPR35)- and aryl hydrocarbon receptor-mediated pathways. Furthermore, we discuss the role of KYNA–GPR35 interaction and microbiota associated KYNA metabolism for gut homeostasis.
1000 Sacherschließung
lokal G-protein-coupled receptor 35
lokal immunomodulation
lokal inflammation
lokal kynurenic acid
lokal aryl hydrocarbon receptor
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/V2lydGhnZW4sIEVsaXNh|http://orcid.org/0000-0003-2018-2836|http://orcid.org/0000-0002-2918-7433|https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIsIEp1bGlhbmU=
1000 Label
1000 Förderer
  1. German Research Foundation (DFG) |
  2. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. GU 1487/1-1
  2. -
1000 Förderprogramm
  1. -
  2. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer GU 1487/1-1
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410255.rdf
1000 Erstellt am 2018-09-18T09:24:12.964+0200
1000 Erstellt von 122
1000 beschreibt frl:6410255
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 21:52:13 CET 2020
1000 Objekt bearb. Tue Sep 18 09:25:22 CEST 2018
1000 Vgl. frl:6410255
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410255 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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