WeightNameValue
1000 Titel
  • Multiple Quantitative Trait Loci Mapping With Cofactors and Application of Alternative Variants of the False Discovery Rate in an Enlarged Granddaughter Design
1000 Autor/in
  1. Bennewitz, Jörn |
  2. Reinsch, Norbert |
  3. Guiard, Volker |
  4. Fritz, Sebastien |
  5. Thomsen, Hauke |
  6. Looft, Christian |
  7. Kuehn, Christa |
  8. Schwerin, Manfred |
  9. Weimann, Christina |
  10. Erhardt, Georg |
  11. Reinhardt, Fritz |
  12. Reents, Reinhard |
  13. Boichard, Didier |
  14. Kalm, Ernst |
1000 Erscheinungsjahr 2004
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2004-10-28
1000 Erschienen in
1000 Quellenangabe
  • 168(2): 1019-1027
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448815/ |
  • https://doi.org/10.1534/genetics.104.030296 |
1000 Ergänzendes Material
  • http://www.genetics.org/content/168/2/1019.figures-only |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The experimental power of a granddaughter design to detect quantitative trait loci (QTL) in dairy cattle is often limited by the availability of progeny-tested sires, by the ignoring of already identified QTL in the statistical analysis, and by the application of stringent experimentwise significance levels. This study describes an experiment that addressed these points. A large granddaughter design was set up that included sires from two countries (Germany and France), resulting in almost 2000 sires. The animals were genotyped for markers on nine different chromosomes. The QTL analysis was done for six traits separately using a multimarker regression that included putative QTL on other chromosomes as cofactors in the model. Different variants of the false discovery rate (FDR) were applied. Two of them accounted for the proportion of truly null hypotheses, which were estimated to be 0.28 and 0.3, respectively, and were therefore tailored to the experiment. A total of 25 QTL could be mapped when cofactors were included in the model—7 more than without cofactors. Controlling the FDR at 0.05 revealed 31 QTL for the two FDR methods that accounted for the proportion of truly null hypotheses. The relatively high power of this study can be attributed to the size of the experiment, to the QTL analysis with cofactors, and to the application of an appropriate FDR.
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QmVubmV3aXR6LCBKw7Zybg==|https://frl.publisso.de/adhoc/creator/UmVpbnNjaCwgTm9yYmVydA==|https://frl.publisso.de/adhoc/creator/R3VpYXJkLCBWb2xrZXI=|https://frl.publisso.de/adhoc/creator/RnJpdHosIFNlYmFzdGllbg==|https://frl.publisso.de/adhoc/creator/VGhvbXNlbiwgSGF1a2U=|https://frl.publisso.de/adhoc/creator/TG9vZnQsIENocmlzdGlhbg==|http://orcid.org/0000-0002-0216-424X|https://frl.publisso.de/adhoc/creator/U2Nod2VyaW4sIE1hbmZyZWQ=|https://frl.publisso.de/adhoc/creator/V2VpbWFubiwgQ2hyaXN0aW5h|https://frl.publisso.de/adhoc/creator/RXJoYXJkdCwgR2Vvcmc=|https://frl.publisso.de/adhoc/creator/UmVpbmhhcmR0LCBGcml0eg==|https://frl.publisso.de/adhoc/creator/UmVlbnRzLCBSZWluaGFyZA==|https://frl.publisso.de/adhoc/creator/Qm9pY2hhcmQsIERpZGllcg==|https://frl.publisso.de/adhoc/creator/S2FsbSwgRXJuc3Q=
1000 Label
1000 Förderer
  1. German Cattle Breeders Federation |
  2. German Ministry of Education, Science, Research and Technology |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Cattle Breeders Federation |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer German Ministry of Education, Science, Research and Technology |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410263.rdf
1000 Erstellt am 2018-09-18T13:06:38.228+0200
1000 Erstellt von 122
1000 beschreibt frl:6410263
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 16:53:21 CET 2020
1000 Objekt bearb. Tue Sep 18 13:07:43 CEST 2018
1000 Vgl. frl:6410263
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410263 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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