WeightNameValue
1000 Titel
  • Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function
1000 Autor/in
  1. Pitcher, Meagan R. |
  2. Ward, Christopher S. |
  3. Arvide, E. Melissa |
  4. Chapleau, Christopher A. |
  5. Pozzo-Miller, Lucas |
  6. Hoeflich, Andreas |
  7. Sivaramakrishnan, Manaswini |
  8. Saenger, Stefanie |
  9. Metzger, Friedrich |
  10. Neul, Jeffrey L. |
1000 Erscheinungsjahr 2013
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-03-05
1000 Erschienen in
1000 Quellenangabe
  • 22(13): 2626-2633
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674803/ |
  • https://doi.org/10.1093/hmg/ddt111 |
1000 Ergänzendes Material
  • https://academic.oup.com/hmg/article/22/13/2626/608693#85658339 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Rett syndrome (RTT), an X-linked postnatal disorder, results from mutations in Methyl CpG-binding protein 2 (MECP2). Survival and breathing in Mecp2NULL/Y animals are improved by an N-terminal tripeptide of insulin-like growth factor I (IGF-I) treatment. We determined that Mecp2NULL/Y animals also have a metabolic syndrome and investigated whether IGF-I treatment might improve this phenotype. Mecp2NULL/Y mice were treated with a full-length IGF-I modified with the addition of polyethylene glycol (PEG-IGF-I), which improves pharmacological properties. Low-dose PEG-IGF-I treatment slightly improved lifespan and heart rate in Mecp2NULL/Y mice; however, high-dose PEG-IGF-I decreased lifespan. To determine whether insulinotropic off-target effects of PEG-IGF-I caused the detrimental effect, we treated Mecp2NULL/Y mice with insulin, which also decreased lifespan. Thus, the clinical benefit of IGF-I treatment in RTT may critically depend on the dose used, and caution should be taken when initiating clinical trials with these compounds because the beneficial therapeutic window is narrow.
1000 Sacherschließung
lokal life spansymptom aggravating factors
lokal heart rate
lokal insulin-like growth factor i
lokal insulin
lokal metabolic syndrome x
lokal inspiration
lokal phenotype
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/UGl0Y2hlciwgTWVhZ2FuIFIu|https://frl.publisso.de/adhoc/creator/V2FyZCwgQ2hyaXN0b3BoZXIgUy4=|https://frl.publisso.de/adhoc/creator/QXJ2aWRlLCBFLiBNZWxpc3Nh|https://frl.publisso.de/adhoc/creator/Q2hhcGxlYXUsIENocmlzdG9waGVyIEEu|https://frl.publisso.de/adhoc/creator/UG96em8tTWlsbGVyLCBMdWNhcw==|http://orcid.org/0000-0003-2018-2836|https://frl.publisso.de/adhoc/creator/U2l2YXJhbWFrcmlzaG5hbiwgTWFuYXN3aW5p|https://frl.publisso.de/adhoc/creator/U2FlbmdlciwgU3RlZmFuaWU=|https://frl.publisso.de/adhoc/creator/TWV0emdlciwgRnJpZWRyaWNo|https://frl.publisso.de/adhoc/creator/TmV1bCwgSmVmZnJleSBMLg==
1000 Label
1000 Förderer
  1. F. Hoffman-La Roche Ltd. |
  2. Jan and Dan Duncan Neurological Research Institute |
  3. Texas Children's Hospital |
  4. US National Institutes of Health |
  5. Med Into Grad Initiative |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. HD062553; NS066601; HD24064; P30 DK079638; NS065027; IRSF-2806 HeART
  5. -
1000 Förderprogramm
  1. -
  2. Cynthia and Anthony Petrello Scholar fund
  3. -
  4. -
  5. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer F. Hoffman-La Roche Ltd. |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Jan and Dan Duncan Neurological Research Institute |
    1000 Förderprogramm Cynthia and Anthony Petrello Scholar fund
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Texas Children's Hospital |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer US National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer HD062553; NS066601; HD24064; P30 DK079638; NS065027; IRSF-2806 HeART
  5. 1000 joinedFunding-child
    1000 Förderer Med Into Grad Initiative |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410304.rdf
1000 Erstellt am 2018-09-25T15:04:55.406+0200
1000 Erstellt von 122
1000 beschreibt frl:6410304
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue May 31 17:25:14 CEST 2022
1000 Objekt bearb. Tue May 31 17:25:14 CEST 2022
1000 Vgl. frl:6410304
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410304 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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