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1000 Titel
  • Dietary Milk Sphingomyelin Reduces Systemic Inflammation in Diet-Induced Obese Mice and Inhibits LPS Activity in Macrophages
1000 Autor/in
  1. Norris, Gregory H. |
  2. Porter, Caitlin M |
  3. Jiang, Christina |
  4. Blesso, Christopher |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-07-21
1000 Erschienen in
1000 Quellenangabe
  • 3(3):37
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/beverages3030037 |
1000 Ergänzendes Material
  • https://www.mdpi.com/2306-5710/3/3/37#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • High-fat diets (HFD) increase lipopolysaccharide (LPS) activity in the blood and may contribute to systemic inflammation with obesity. We hypothesized that dietary milk sphingomyelin (SM), which reduces lipid absorption and colitis in mice, would reduce inflammation and be mediated through effects on gut health and LPS activity. C57BL/6J mice were fed high-fat, high-cholesterol diets (HFD, n = 14) or the same diets with milk SM (HFD-MSM, 0.1% by weight, n = 14) for 10 weeks. HFD-MSM significantly reduced serum inflammatory markers and tended to lower serum LPS (p = 0.08) compared to HFD. Gene expression related to gut barrier function and macrophage inflammation were largely unchanged in colon and mesenteric adipose tissues. Cecal gut microbiota composition showed greater abundance of Acetatifactor genus in mice fed milk SM, but minimal changes in other taxa. Milk SM significantly attenuated the effect of LPS on pro-inflammatory gene expression in RAW264.7 macrophages. Milk SM lost its effects when hydrolysis was blocked, while long-chain ceramides and sphingosine, but not dihydroceramides, were anti-inflammatory. Our data suggest that dietary milk SM may be effective in reducing systemic inflammation through inhibition of LPS activity and that hydrolytic products of milk SM are important for these effects.
1000 Sacherschließung
lokal ceramide
lokal inflammation
lokal sphingolipids
lokal gut
lokal milk
lokal macrophage
lokal sphingomyelin
lokal dairy
lokal sphingosine
lokal obesity
1000 Fachgruppe
  1. Gesundheitswesen |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Tm9ycmlzLCBHcmVnb3J5IEgu|https://frl.publisso.de/adhoc/creator/UG9ydGVyLCBDYWl0bGluIE0=|https://frl.publisso.de/adhoc/creator/SmlhbmcsIENocmlzdGluYQ==|http://orcid.org/0000-0002-4434-4839
1000 (Academic) Editor
1000 Förderer
  1. University of Connecticut |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer University of Connecticut |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410307.rdf
1000 Erstellt am 2018-09-27T12:21:41.002+0200
1000 Erstellt von 286
1000 beschreibt frl:6410307
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Oct 11 14:24:00 CEST 2018
1000 Objekt bearb. Thu Oct 11 14:24:00 CEST 2018
1000 Vgl. frl:6410307
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410307 |
1000 Sichtbarkeit Metadaten public
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