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WeightNameValue
1000 Titel
  • Genetic variants of major genes contributing to phosphate and calcium homeostasis and their association with serum parameters in pigs
1000 Autor/in
  1. Just, Franziska |
  2. Reyer, Henry |
  3. Muráni, Eduard |
  4. Ponsuksili, Siriluck |
  5. Oster, Michael |
  6. Wimmers, Klaus |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-06-22
1000 Erschienen in
1000 Quellenangabe
  • 59(3): 325-333
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1007/s13353-018-0449-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061000/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007%2Fs13353-018-0449-2#SupplementaryMaterial |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Calcium and phosphorus are irreplaceable components of life. Tracking the fate of calcium and phosphorus in organisms deserves high attention due to their relevance in bone metabolism and subsequently animal health. Indeed, bone serves as reservoir for calcium and phosphorus, whose formation and resorption follow specific molecular routes including hormones, receptors, and transcription factors. The objective of the study was to analyze the genetic variation of major components driving mineral utilization such as calcitonin receptor, calcium sensing receptor, fibroblast growth factor 23 (FGF23), parathyroid hormone receptor, osteopontin, stanniocalcin 1, RAF-type zinc finger domain containing 1 (TRAFD1), and vitamin D receptor. A German Landrace pig population (n = 360) was used to perform an association analysis between selected single nucleotide polymorphisms (SNP) and relevant serum parameters (calcium, phosphorus, calcium/phosphorus ratio, alkaline phosphatase). Analyzed SNPs in FGF23 (rs710498025) and TRAFD1 (rs345195312) were significantly (p ≤ 0.05) associated with the serum calcium/phosphorus ratio and serum phosphorus levels, respectively. This might represent a modulation of the homeostatic balance between calcium and phosphorus. Furthermore, TRAFD1 is known to be involved in skeletal disorders which emphasize its link to phosphorus utilization and immune system. However, none of the analyzed genetic variants of these major regulators of phosphate and calcium homeostasis showed significant associations after correction for multiple testing (q value > 0.05). Thus, minor contributors as well as unknown and yet to be elucidated regulators of mineral homeostasis need to be characterized towards the implementation of improved phosphorus efficiency in pig breeding programs.
1000 Sacherschließung
lokal Calcium
lokal Association analysis
lokal Phosphorus
lokal Single nucleotide polymorphism
lokal Bone metabolism
1000 Fachgruppe
  1. Agrarwissenschaften |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SnVzdCwgRnJhbnppc2th|http://orcid.org/0000-0001-6470-0434|https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/V2ltbWVycywgS2xhdXM=
1000 Förderer
  1. Leibniz Science Campus Phosphorus Research Rostock |
  2. European Union (EU) |
1000 Fördernummer
  1. -
  2. FP7/2007–2013; 311794
1000 Förderprogramm
  1. -
  2. Seventh Framework Programme; ECO-FCE project
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Science Campus Phosphorus Research Rostock |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Union (EU) |
    1000 Förderprogramm Seventh Framework Programme; ECO-FCE project
    1000 Fördernummer FP7/2007–2013; 311794
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410575.rdf
1000 Erstellt am 2018-10-15T13:04:38.622+0200
1000 Erstellt von 122
1000 beschreibt frl:6410575
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed Oct 17 11:24:17 CEST 2018
1000 Objekt bearb. Wed Oct 17 11:24:17 CEST 2018
1000 Vgl. frl:6410575
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410575 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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