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1000 Titel
  • miRNAs regulate acute transcriptional changes in broiler embryos in response to modification of incubation temperature
1000 Autor/in
  1. Naraballobh, Watcharapong |
  2. Trakooljul, Nares |
  3. Muráni, Eduard |
  4. Krischek, Carsten |
  5. Janisch, Sabine |
  6. Wicke, Michael |
  7. Ponsuksili, Siriluck |
  8. Wimmers, Klaus |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-07-27
1000 Erschienen in
1000 Quellenangabe
  • 8:11371
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1038/s41598-018-29316-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063901/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-018-29316-7#Sec20 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • MicroRNAs are post-transcriptional regulators that play critical roles in diverse biological processes. We hypothesize that miRNAs may be involved in regulating transcriptome responses to changes in embryonic incubation temperature in chickens affecting differentiation and proliferation processes during tissue development. Therefore, we conducted comparative transcriptome profiling of miRNAs to examine altered expression in breast and hind muscle of embryos and day 35 chickens experiencing high (38.8 °C), control (37.8 °C), or low (36.8 °C) embryonic incubation temperature during embryonic day (ED) 7–10 or ED10–13. The results revealed differential expression of miRNAs due to modification of embryonic incubation temperature in a muscle type-specific and a developmental stage-specific manner. The immediate effects of thermal change observed in embryos were substantial compared to the subtle long-term effects in chickens at day 35 post-hatch. Upregulation of miR-133 in breast muscle and downregulation of miR-199a-5p, miR-1915, and miR-638 in hind muscle post ED7–10 high-temperature treatment are functionally associated with myogenesis and body size. ED10–13 low-temperature treatment led to downregulation of let-7, miR-93, and miR-130c that are related to proliferation and differentiation. The results provide insight into the dynamics of miRNA expression at variable embryonic incubation temperatures during developmental processes and indicate a major regulatory role of miRNAs in acute responses to modified environmental conditions that affect remodelling of cells and tissues.
1000 Sacherschließung
lokal Animal breeding
lokal Gene expression profiling
lokal Agricultural genetics
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TmFyYWJhbGxvYmgsIFdhdGNoYXJhcG9uZw==|https://frl.publisso.de/adhoc/creator/VHJha29vbGp1bCwgTmFyZXM=|https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/S3Jpc2NoZWssIENhcnN0ZW4=|https://frl.publisso.de/adhoc/creator/SmFuaXNjaCwgU2FiaW5l|https://frl.publisso.de/adhoc/creator/V2lja2UsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|http://orcid.org/0000-0002-9523-6790
1000 Label
1000 Förderer
  1. German Research Foundation (DFG) |
1000 Fördernummer
  1. WI 1754/15–1; WI 2072/9-1; KR 3993/4-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer WI 1754/15–1; WI 2072/9-1; KR 3993/4-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410608.rdf
1000 Erstellt am 2018-10-16T12:01:33.179+0200
1000 Erstellt von 122
1000 beschreibt frl:6410608
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 19:19:10 CET 2020
1000 Objekt bearb. Wed Oct 17 12:03:22 CEST 2018
1000 Vgl. frl:6410608
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410608 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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