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WeightNameValue
1000 Titel
  • Transcriptional shifts account for divergent resource allocation in feed efficient broiler chickens
1000 Autor/in
  1. Reyer, Henry |
  2. Metzler-Zebeli, Barbara U. |
  3. Trakooljul, Nares |
  4. Oster, Michael |
  5. Muráni, Eduard |
  6. Ponsuksili, Siriluck |
  7. Hadlich, Frieder |
  8. Wimmers, Klaus |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-08-27
1000 Erschienen in
1000 Quellenangabe
  • 8:12903
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1038/s41598-018-31072-7 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110741/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-018-31072-7#Sec16 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Considerable variation in feed efficiency (FE) has been observed in indigenous and selected meat-type chicken populations. Although this variation could be partially linked to extrinsic factors like diet, housing environment and microbiota, it further illustrates the existence of strong molecular mechanisms enabling the differential allocation of resources for various physiological processes. To further deepen the molecular basis of individual allocation capacity in male and female broilers, an RNA-seq experiment was conducted which based on a phenotyped chicken population divergent in FE. Transcriptional differences linked to FE were pronounced in intestinal and muscular tissue sites of male animals. Specifically, signalling pathways of farnesoid X receptor (FXR) and retinoid X receptor (RXR) might contribute to mediate individual FE. The transcriptional profiles suggested ACSBG2 (muscular lipid utilisation), ASBT (intestinal bile salt transport), CLEC2B (natural killer cell activation), HMGCS2 (jejunal, duodenal and muscular ketogenesis), and SCARB1 (jejunal lipid uptake) as potential mediators driving FE. Results indicate that improvements in FE exploit shifts in resource allocation which might occur at the expense of general immune responsiveness in high efficient male chickens. Consequently, to further improve FE traits and to explore causative molecular patterns, effects originating from sex-dimorphism in chickens need to be taken into consideration.
1000 Sacherschließung
lokal Gene expression profiling
lokal Transcriptomics
1000 Fachgruppe
  1. Agrarwissenschaften |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0001-6470-0434|https://frl.publisso.de/adhoc/creator/TWV0emxlci1aZWJlbGksIEJhcmJhcmEgVS4=|https://frl.publisso.de/adhoc/creator/VHJha29vbGp1bCwgTmFyZXM=|https://frl.publisso.de/adhoc/creator/T3N0ZXIsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/creator/TXVyw6FuaSwgRWR1YXJk|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSwgU2lyaWx1Y2s=|https://frl.publisso.de/adhoc/creator/SGFkbGljaCwgRnJpZWRlcg==|http://orcid.org/0000-0002-9523-6790
1000 Förderer
  1. European Union (EU) |
  2. Leibniz Institute for Farm Animal Biology (FBN) |
1000 Fördernummer
  1. FP7/2007–2013; 311794
  2. -
1000 Förderprogramm
  1. Seventh Framework Programme; ECO-FCE
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Union (EU) |
    1000 Förderprogramm Seventh Framework Programme; ECO-FCE
    1000 Fördernummer FP7/2007–2013; 311794
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Farm Animal Biology (FBN) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410610.rdf
1000 Erstellt am 2018-10-16T12:15:06.652+0200
1000 Erstellt von 122
1000 beschreibt frl:6410610
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed Oct 17 12:06:30 CEST 2018
1000 Objekt bearb. Wed Oct 17 12:06:30 CEST 2018
1000 Vgl. frl:6410610
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410610 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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