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1000 Titel
  • An examination of whether associations exist between maternal and neonatal 25OHD and infant size and adiposity at birth, 6–9 months and 2–2.5 years of age – a longitudinal observational study from the ROLO study
1000 Autor/in
  1. Horan, Mary K. |
  2. Donnelly, Jean M. |
  3. McKenna, Malachi J. |
  4. Crosbie, Brenda |
  5. Kilbane, Mark T. |
  6. McAuliffe, Fionnuala M. |
1000 Erscheinungsjahr 2017
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-07-17
1000 Erschienen in
1000 Quellenangabe
  • 3:62
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s40795-017-0184-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050699/ |
1000 Ergänzendes Material
  • https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-017-0184-9#Decs |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Vitamin D status in pregnancy and offspring bone health effects are well established, yet limited knowledge exists on the effect of maternal vitamin D status on offspring size/adiposity. This study examines the association of early (13 weeks), late (28 weeks) pregnancy and neonatal (umbilical) 25-hydroxyvitamin D (25OHD) on offspring size/adiposity. METHODS: This analysis included mother-infant pairs from the ROLO study at birth (n = 292), 6–9 months (n = 160) and 2–2.5 years (n = 287) postpartum. RESULTS: Using Institute of Medicine 2011 Report criteria, 30% of women in early pregnancy and 38% in late pregnancy were at risk of vitamin D deficiency (25OHD < 30 nmol/L). Birthweight was negatively associated with early-pregnancy 25OHD (p = 0.004) and neonatal 25OHD (p < 0.001). Birth length was not associated with 25OHD. Neonatal measures of overall adiposity were negatively associated with neonatal 25OHD (p = 0.001, and p = <0.001 respectively). At 2–2.5 years there was a negative association between weight-for-age z-score and early-pregnancy 25OHD (p < 0.041). CONCLUSIONS: Maternal and neonatal 25OHD were negatively associated with offspring size/adiposity at birth and offspring weight-for-age at 2–2.5 years. Results may not reflect a general population replete in vitamin D, due to high prevalence of macrosomia and high risk of deficiency in this cohort. Improvement of pregnancy vitamin D status remains a public health concern. TRIAL REGISTRATION: Current Controlled Trials ISRCTN54392969. 22/04/2009 retrospectively registered.
1000 Sacherschließung
lokal ROLO study
lokal Childhood obesity
lokal Maternal nutrition
lokal Maternal vitamin D
lokal Fetal programming
lokal Offspring adiposity
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SG9yYW4sIE1hcnkgSy4=|https://frl.publisso.de/adhoc/creator/RG9ubmVsbHksIEplYW4gTS4=|https://frl.publisso.de/adhoc/creator/TWNLZW5uYSwgTWFsYWNoaSBKLg==|https://frl.publisso.de/adhoc/creator/Q3Jvc2JpZSwgQnJlbmRh|https://frl.publisso.de/adhoc/creator/S2lsYmFuZSwgTWFyayBULg==|https://frl.publisso.de/adhoc/creator/TWNBdWxpZmZlLCBGaW9ubnVhbGEgTS4=
1000 Label
1000 Förderer
  1. Health Research Board Ireland |
  2. Health Research Centre for Health and Diet Research |
  3. National Maternity Hospital |
  4. European Union |
1000 Fördernummer
  1. -
  2. -
  3. -
  4. FP7/2007–2013; 289346
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. Seventh Framework Programme; EarlyNutrition
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Health Research Board Ireland |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Health Research Centre for Health and Diet Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer National Maternity Hospital |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm Seventh Framework Programme; EarlyNutrition
    1000 Fördernummer FP7/2007–2013; 289346
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410648.rdf
1000 Erstellt am 2018-10-18T12:51:13.161+0200
1000 Erstellt von 218
1000 beschreibt frl:6410648
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Fri Sep 03 15:55:43 CEST 2021
1000 Objekt bearb. Fri Sep 03 15:55:43 CEST 2021
1000 Vgl. frl:6410648
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410648 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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