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1000 Titel
  • Increased Concentrations of Insulin-Like Growth Factor Binding Protein (IGFBP)-2, IGFBP-3, and IGFBP-4 Are Associated With Fetal Mortality in Pregnant Cows
1000 Autor/in
  1. Mense, Kirsten |
  2. Heidekorn-Dettmer, Julia |
  3. Wirthgen, Elisa |
  4. Brockelmann, Yette |
  5. Bortfeldt, Ralf |
  6. Peter, Sarah |
  7. Jung, Markus |
  8. Höflich, Christine |
  9. Hoeflich, Andreas |
  10. Schmicke, Marion |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-06-12
1000 Erschienen in
1000 Quellenangabe
  • 9:310
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fendo.2018.00310 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006986/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Insulin-like growth factors (IGFs) play a critical role in fetal growth, and components of the IGF system have been associated with fetal growth restriction in women. In human pregnancy, the proteolytic cleavage of insulin-like growth factor binding proteins (IGFBPs), particularly IGFBP-4, releases free IGF for respective action at the tissue level. The aim of the present study was to determine IGFBP-2, IGFBP-3, and IGFBP-4 concentrations by Western ligand blotting during pregnancy until day 100 in cows and to compare these concentrations with those of non-pregnant cows and cows undergoing embryonic/fetal mortality. Therefore, two study trials (I and II) and an in vitro study were conducted. In study I, 43 cows were not pregnant, 34 cows were pregnant, and 4 cows were undergoing fm. In study II, 500 cows were examined, and 7 cases of pregnancy loss between days 24–27 and 34–37 after artificial insemination (AI, late embryonic mortality; em) and 8 cases of pregnancy loss between days 34–37 and 54–57 after AI (late embryonic mortality and early fetal mortality; em/fm) were defined from the analyses of 30 pregnant and 20 non-pregnant cows randomly selected for insulin-like growth factor 1 and IGFBP analyses. In vitro serum from pregnant (n = 3) and non-pregnant (n = 3) cows spiked after incubation with recombinant human (rh) IGFBP-4 for 24 h, and IGFBP-4 levels were analyzed before and after incubation to detect proteolytic degradation. The IGFBP-2, -3, and -4 concentrations did not decline during early pregnancy in cows, while IGFBP-4 concentrations were comparable between pregnant and non-pregnant cows, irrespective of low proteolytic activity, which was also demonstrated in cows. Interestingly, cows with em or fm showed distinct IGFBP patterns. The IGFBP-2 and -3 concentrations were higher (P < 0.05) in cows with fm compared to pregnant. The IGFBP-4 levels were significantly higher in cows developing fm. Thus, distinct differences in the circulating IGFBP concentrations could be associated with late embryonic and early fetal losses in cattle.
1000 Sacherschließung
lokal pregnancy
lokal bovine
lokal IGF-1
lokal embryonic mortality
lokal gestation
lokal binding protein
1000 Fachgruppe
  1. Agrarwissenschaften |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWVuc2UsIEtpcnN0ZW4=|https://frl.publisso.de/adhoc/creator/SGVpZGVrb3JuLURldHRtZXIsIEp1bGlh|https://frl.publisso.de/adhoc/creator/V2lydGhnZW4sIEVsaXNh|https://frl.publisso.de/adhoc/creator/QnJvY2tlbG1hbm4sIFlldHRl|https://frl.publisso.de/adhoc/creator/Qm9ydGZlbGR0LCBSYWxm|https://frl.publisso.de/adhoc/creator/UGV0ZXIsIFNhcmFo|https://frl.publisso.de/adhoc/creator/SnVuZywgTWFya3Vz|https://frl.publisso.de/adhoc/creator/SMO2ZmxpY2gsIENocmlzdGluZQ==|http://orcid.org/0000-0003-2018-2836|https://frl.publisso.de/adhoc/creator/U2NobWlja2UsIE1hcmlvbg==
1000 Label
1000 Förderer
  1. Saxon State Office for Environment, Agriculture and Geology |
  2. State Office for Rural Development, Environment and Agriculture of Brandenburg |
  3. Förderverein Bioökonomieforschung e.V. |
  4. Deutsche Forschungsgemeinschaft (DFG) |
  5. University of Veterinary Medicine Hannover |
1000 Fördernummer
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1000 Förderprogramm
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  5. Open Access Publishing
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Saxon State Office for Environment, Agriculture and Geology |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer State Office for Rural Development, Environment and Agriculture of Brandenburg |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Förderverein Bioökonomieforschung e.V. |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer University of Veterinary Medicine Hannover |
    1000 Förderprogramm Open Access Publishing
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6410750.rdf
1000 Erstellt am 2018-10-24T13:04:16.235+0200
1000 Erstellt von 122
1000 beschreibt frl:6410750
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 21:56:09 CET 2020
1000 Objekt bearb. Thu Jan 17 13:29:34 CET 2019
1000 Vgl. frl:6410750
1000 Oai Id
  1. oai:frl.publisso.de:frl:6410750 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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