Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

  1. Pastorino, Roberta
  2. Puggina, Anna
  3. Carreras-Torres, Robert
  4. Lagiou, Pagona
  5. Holcátová, Ivana
  6. Richiardi, Lorenzo
  7. Kjaerheim, Kristina
  8. Agudo, Antonio
  9. Castellsagué, Xavier
  10. Macfarlane, Tatiana V.
  11. Barzan, Luigi
  12. Canova, Cristina
  13. Thakker, Nalin S.
  14. Conway, David I.
  15. Znaor, Ariana
  16. Healy, Claire M.
  17. Ahrens, Wolfgang ORCID logo
  18. Zaridze, David
  19. Szeszenia-Dabrowska, Neonilia
  20. Lissowska, Jolanta
  21. Fabianova, Eleonora
  22. Mates, Ioan Nicolae
  23. Bencko, Vladimir
  24. Foretova, Lenka
  25. Janout, Vladimir
  26. Brennan, Paul
  27. Gaborieau, Valérie
  28. McKay, James D.
  29. Boccia, Stefania

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1000 Titel
  • Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis
1000 Autor/in
  1. Pastorino, Roberta |
  2. Puggina, Anna |
  3. Carreras-Torres, Robert |
  4. Lagiou, Pagona |
  5. Holcátová, Ivana |
  6. Richiardi, Lorenzo |
  7. Kjaerheim, Kristina |
  8. Agudo, Antonio |
  9. Castellsagué, Xavier |
  10. Macfarlane, Tatiana V. |
  11. Barzan, Luigi |
  12. Canova, Cristina |
  13. Thakker, Nalin S. |
  14. Conway, David I. |
  15. Znaor, Ariana |
  16. Healy, Claire M. |
  17. Ahrens, Wolfgang |
  18. Zaridze, David |
  19. Szeszenia-Dabrowska, Neonilia |
  20. Lissowska, Jolanta |
  21. Fabianova, Eleonora |
  22. Mates, Ioan Nicolae |
  23. Bencko, Vladimir |
  24. Foretova, Lenka |
  25. Janout, Vladimir |
  26. Brennan, Paul |
  27. Gaborieau, Valérie |
  28. McKay, James D. |
  29. Boccia, Stefania |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-03-14
1000 Erschienen in
1000 Quellenangabe
  • 8: 4534
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/s41598-018-22626-w |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852094/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-018-22626-w#Sec8 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW). MR-Egger regression was used for sensitivity analysis and pleiotropy evaluation. From the GRS analysis, one standard deviation (SD) higher height (6.9 cm; due to genetic predisposition across 599 SNPs) raised the risk for HNC (Odds ratio (OR), 1.14; 95% Confidence Interval (95%CI), 0.99–1.32). The association analyses with potential confounders revealed that the GRS was associated with tobacco smoking (OR = 0.80, 95% CI (0.69–0.93)). MR-Egger regression did not provide evidence of overall directional pleiotropy. Our study indicates that height is potentially associated with HNC risk. However, the reported risk could be underestimated since, at the genetic level, height emerged to be inversely associated with smoking.
1000 Sacherschließung
lokal Cancer epidemiology
lokal Risk factors
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. Italian Association for Research on Cancer (AIRC)
  2. European Union
1000 Fördernummer
  1. IG 2013 n. 14211
  2. 645740
1000 Förderprogramm
  1. -
  2. Horizon 2020 research and innovation programme MSCA-RISE-2014: Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)
1000 Dateien
  1. Pastorino-et-al_2018_Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer_A Mendelian Randomization Analysis
    Pastorino-et-al_2018_Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer_A Mendelian Randomization Analysis
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6411699.rdf
1000 Erstellt am 2018-12-10T14:30:25.384+0100
1000 Erstellt von 266
1000 beschreibt frl:6411699
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2020-01-30T19:27:57.123+0100
1000 Objekt bearb. Fri Dec 14 11:20:51 CET 2018
1000 Vgl. frl:6411699
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  1. oai:frl.publisso.de:frl:6411699 |
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