Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project

  1. Masclee, Gwen M.C.
  2. Straatman, Huub
  3. Arfè, Andrea
  4. Castellsagué, Jordi
  5. Garbe, Edeltraut
  6. Herings, Ron
  7. Kollhorst, Bianca
  8. Lucchi, Silvia
  9. Perez-Gutthan, Susana
  10. Romio, Silvana
  11. Schade, René
  12. Schink, Tania ORCID logo
  13. Schumie, Martijn J.
  14. Scotti, Lorenza
  15. Varas-Lorenzo, Cristina
  16. Valkhoff, Vera E.
  17. Villa, Marco
  18. Sturkenboom, Miriam C. J. M.

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WeightNameValue
1000 Titel
  • Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project
1000 Autor/in
  1. Masclee, Gwen M.C. |
  2. Straatman, Huub |
  3. Arfè, Andrea |
  4. Castellsagué, Jordi |
  5. Garbe, Edeltraut |
  6. Herings, Ron |
  7. Kollhorst, Bianca |
  8. Lucchi, Silvia |
  9. Perez-Gutthan, Susana |
  10. Romio, Silvana |
  11. Schade, René |
  12. Schink, Tania |
  13. Schumie, Martijn J. |
  14. Scotti, Lorenza |
  15. Varas-Lorenzo, Cristina |
  16. Valkhoff, Vera E. |
  17. Villa, Marco |
  18. Sturkenboom, Miriam C. J. M. |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-11-01
1000 Erschienen in
1000 Quellenangabe
  • 13(11): e0204746
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0204746 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211656/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204746#sec016 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Use of selective COX-2 non-steroidal anti-inflammatory drugs (NSAIDs) (coxibs) has been associated with an increased risk of acute myocardial infarction (AMI). However, the risk of AMI has only been studied for very few NSAIDs that are frequently used. OBJECTIVES: To estimate the risk of AMI for individual NSAIDs. METHODS: A nested case-control study was performed from a cohort of new NSAID users ≥18 years (1999–2011) matching cases to a maximum of 100 controls on database, sex, age, and calendar time. Data were retrieved from six healthcare databases. Adjusted odds ratios (ORs) of current use of individual NSAIDs compared to past use were estimated per database. Pooling was done by two-stage pooling using a random effects model (ORmeta) and by one-stage pooling (ORpool). RESULTS: Among 8.5 million new NSAID users, 79,553 AMI cases were identified. The risk was elevated for current use of ketorolac (ORmeta 2.06;95%CI 1.83–2.32, ORpool 1.80; 1.49–2.18) followed, in descending order of point estimate, by indometacin, etoricoxib, rofecoxib, diclofenac, fixed combination of diclofenac with misoprostol, piroxicam, ibuprofen, naproxen, celecoxib, meloxicam, nimesulide and ketoprofen (ORmeta 1.12; 1.03–1.22, ORpool 1.00;0.86–1.16). Higher doses showed higher risk estimates than lower doses. CONCLUSIONS: The relative risk estimates of AMI differed slightly between 28 individual NSAIDs. The relative risk was highest for ketorolac and was correlated with COX-2 potency, but not restricted to coxibs.
1000 Sacherschließung
lokal Medical risk factors
lokal COX-2 inhibitors
lokal Coronary heart disease
lokal Database and informatics methods
lokal NSAIDs
lokal Case-control studies
lokal Metaanalysis
lokal Myocardial infarction
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWFzY2xlZSwgR3dlbiBNLkMu|https://frl.publisso.de/adhoc/creator/U3RyYWF0bWFuLCBIdXVi|https://frl.publisso.de/adhoc/creator/QXJmw6gsIEFuZHJlYQ==|https://frl.publisso.de/adhoc/creator/Q2FzdGVsbHNhZ3XDqSwgSm9yZGk=|https://frl.publisso.de/adhoc/creator/R2FyYmUsIEVkZWx0cmF1dA==|https://frl.publisso.de/adhoc/creator/SGVyaW5ncywgUm9u|https://frl.publisso.de/adhoc/creator/S29sbGhvcnN0LCBCaWFuY2E=|https://frl.publisso.de/adhoc/creator/THVjY2hpLCBTaWx2aWE=|https://frl.publisso.de/adhoc/creator/UGVyZXotR3V0dGhhbiwgU3VzYW5h|https://frl.publisso.de/adhoc/creator/Um9taW8sIFNpbHZhbmE=|https://frl.publisso.de/adhoc/creator/U2NoYWRlLCBSZW7DqQ==|http://orcid.org/0000-0002-0224-1866|https://frl.publisso.de/adhoc/creator/U2NodW1pZSwgTWFydGlqbiBKLg==|https://frl.publisso.de/adhoc/creator/U2NvdHRpLCBMb3Jlbnph|https://frl.publisso.de/adhoc/creator/VmFyYXMtTG9yZW56bywgQ3Jpc3RpbmE=|https://frl.publisso.de/adhoc/creator/VmFsa2hvZmYsIFZlcmEgRS4=|https://frl.publisso.de/adhoc/creator/VmlsbGEsIE1hcmNv|https://frl.publisso.de/adhoc/creator/U3R1cmtlbmJvb20sIE1pcmlhbSBDLiBKLiBNLg==
1000 Label
1000 Förderer
  1. European Community |
1000 Fördernummer
  1. 223495 (the SOS project)
1000 Förderprogramm
  1. Seventh Framework Programme
1000 Dateien
  1. Masclee-et-al_2018_Risk of acute myocardial infarction during use of individual NSAIDs_A nested case-control study from the SOS project
    Masclee-et-al_2018_Risk of acute myocardial infarction during use of individual NSAIDs_A nested case-control study from the SOS project
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Seventh Framework Programme
    1000 Fördernummer 223495 (the SOS project)
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6411831.rdf
1000 Erstellt am 2018-12-17T14:39:47.628+0100
1000 Erstellt von 266
1000 beschreibt frl:6411831
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue Jan 05 09:36:10 CET 2021
1000 Objekt bearb. Tue Jan 05 09:36:10 CET 2021
1000 Vgl. frl:6411831
1000 Oai Id
  1. oai:frl.publisso.de:frl:6411831 |
1000 Sichtbarkeit Metadaten public
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