Iacomino-et-al_2019_Circulating microRNAs are associated with early childhood obesity_Results of the I.Family Study.pdf 1,91MB
1000 Titel
  • Circulating microRNAs are associated with early childhood obesity: results of the I.Family Study
1000 Autor/in
  2. Russo, Paola |
  3. Marena, Pasquale |
  4. Lauria, Fabio |
  5. Venezia, Antonella |
  6. Ahrens, Wolfgang |
  7. De Henauw, Stefaan |
  8. De Luca, Pasquale |
  9. Foraita, Ronja |
  10. Günther, Kathrin |
  11. Lissner, Lauren |
  12. Molnar, Dénes |
  13. Moreno, Luis A. |
  14. Tornaritis, Michael |
  15. Veidebaum, Toomas |
  16. Siani, Alfonso |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-01-09
1000 Erschienen in
1000 Quellenangabe
  • 14: 2
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Ergänzendes Material
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Nearly 10 years ago, the World Health Organization reported the increasing prevalence of overweight and obesity worldwide as a challenge for public health due to the associated adverse consequences. Epidemiological studies established a firm relationship between an elevated body mass index and chronic conditions such as diabetes, dyslipidemia, hypertension, heart disease, non-alcoholic fatty liver disease, and some types of cancer. Omic studies demonstrated that microRNA (miRNA) profile changes in tissues correlate with a number of diseases, including obesity. Recent studies showed a remarkable stability of miRNAs also in blood, emphasizing their potential as theranostic agents for a variety of disorders and conditions. A number of miRNAs enriched in homeostasis of obesity and metabolic disorders have been characterized in previous researches. AIM: This work was finalized to investigate the differential circulating miRNAs signature in early childhood obesity. Our cross-sectional study analyzed the signature of circulating miRNAs in plasma samples of normal weight (n = 159) and overweight/obese (n = 149) children and adolescents participating to the I.Family study, an EC-funded study finalized to investigate the etiology of overweight, obesity and related disorders and the determinants of food choice, lifestyle, and related health outcomes in children and adolescents of eight European countries ( RESULTS: Differences in miRNA signature with respect to anthropometric and biochemical variables were analyzed. A high degree of variability in levels of circulating miRNAs was identified among children from different countries, in line with recent reports supporting the hypothesis that these molecules are likewise affected by environmental and lifestyle factors. A panel of miRNAs differentially expressed in overweight/low-grade obesity children was characterized (miR-551a and miR-501-5p resulted upregulated; miR-10b-5p, miR-191-3p, miR-215-5p, and miR-874-3p resulted downregulated). ROC curves were also constructed for experimentally confirmed miRNAs. Single miRNAs generally exhibited low AUC values with the highest values for miR-874-3p and miR-501-5p which in combination provided an interesting value (AUC = 0.782). Pearson’s analysis confirmed that miR-10b-5p, miR-215-5p, miR-501-5p, miR-551a, and miR-874-3p significantly correlated with BMI z-score. Molecular interactions of obesity-associated miRNAs were also predicted by bioinformatics tools. CONCLUSIONS: Our work showed that several circulating miRNAs are differentially represented in overweight/low-grade obesity children and adolescents. Although causal pathways cannot be firmly inferred, it is conceivable that circulating miRNAs may be new biomarkers of early childhood obesity.
1000 Sacherschließung
lokal Childhood obesity
lokal Childhood overweight/low-grade obesity
lokal Metabolic disorders
lokal Circulating miRNAs
lokal Biomarker
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. European Community |
1000 Fördernummer
  1. 266044
1000 Förderprogramm
  1. Seventh Framework Programme
1000 Dateien
  1. Circulating microRNAs are associated with early childhood obesity: Results of the I.Family Study
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community |
    1000 Förderprogramm Seventh Framework Programme
    1000 Fördernummer 266044
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6413182.rdf
1000 Erstellt am 2019-03-01T13:47:37.045+0100
1000 Erstellt von 266
1000 beschreibt frl:6413182
1000 Bearbeitet von 266
1000 Zuletzt bearbeitet Mon Sep 28 15:15:31 CEST 2020
1000 Objekt bearb. Mon Sep 28 15:15:31 CEST 2020
1000 Vgl. frl:6413182
1000 Oai Id
  1. |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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