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Pisa-et-al_2019_Antidepressants and the risk of traumatic brain injury in the elderly_Differences between individual agents.pdf 393,59KB
WeightNameValue
1000 Titel
  • Antidepressants and the risk of traumatic brain injury in the elderly: differences between individual agents
1000 Autor/in
  1. Pisa, Federica Edith |
  2. Reinold, Jonas |
  3. Kollhorst, Bianca |
  4. Haug, Ulrike |
  5. Schink, Tania |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-2-15
1000 Erschienen in
1000 Quellenangabe
  • 11: 185-196
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.2147/CLEP.S173667 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVE: To determine the association of individual antidepressants (ADs) with the risk of traumatic brain injury (TBI) in the elderly. PATIENTS AND METHODS: We conducted a case–control study nested in a cohort of new users of ADs aged ≥65 years, identified in the German Pharmacoepidemiological Research Database during 2005–2014. Cases were patients first hospitalized for TBI. Up to 100 controls per case were selected using incidence density sampling. AD use was ascertained at the index date based on the supply of last dispensing (adding 150% of the defined daily doses [DDDs]; in sensitivity analysis, no additional DDDs were considered). We estimated adjusted ORs (aORs) and 95% CIs using conditional logistic regression. RESULTS: Among 701,309 cohort members, 16,750 cases were identified and matched to 1,673,320 controls (in both groups: 70.4% women; median age 80 years). Compared with remote users of the same AD, current users had an aOR (95% CI) of 1.87 (1.56–2.24) for duloxetine, 1.74 (1.41–2.15) for escitalopram, 1.70 (1.58–1.83) for citalopram, 1.66 (1.40–1.97) for sertraline, 1.64 (1.24–2.15) for fluoxetine and 1.57 (1.20–2.06) for paroxetine. The aOR was lower for amitriptyline (1.45; 1.32–1.58), trimipramine (1.17; 0.99–1.38) and opipramol (1.11; 0.99–1.25). Mirtazapine had an aOR of 1.03 (0.94–1.12). Sensitivity analysis confirmed the findings. CONCLUSION: The large variability between individual ADs shows the importance of considering the safety of individual agents rather than focusing on class alone.
1000 Sacherschließung
lokal Pharmacoepidemiology
lokal Traumatic brain injury
lokal Antidepressants
lokal Elderly
lokal Health insurance claims databases
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-0459-2616|https://orcid.org/0000-0001-8266-2574|https://orcid.org/0000-0001-5964-954X|https://orcid.org/0000-0002-1886-2923|https://orcid.org/0000-0002-0224-1866
1000 Label
1000 Förderer
  1. German Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte) |
  2. Leibniz Association |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. Open Access Fund
1000 Dateien
  1. Antidepressants and the risk of traumatic brain injury in the elderly: Differences between individual agents
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte) |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6413186.rdf
1000 Erstellt am 2019-03-01T14:10:18.156+0100
1000 Erstellt von 266
1000 beschreibt frl:6413186
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Fri Jan 31 00:52:52 CET 2020
1000 Objekt bearb. Fri Mar 08 12:58:47 CET 2019
1000 Vgl. frl:6413186
1000 Oai Id
  1. oai:frl.publisso.de:frl:6413186 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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