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1000 Titel
  • Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging
1000 Autor/in
  1. Ain, Quartul |
  2. Schmeer, Christian |
  3. Penndorf, Diane |
  4. Fischer, Mike |
  5. Bondeva, Tzvetanka |
  6. Förster, Martin |
  7. Haenold, Ronny |
  8. Witte, Otto W. |
  9. Kretz, Alexandra |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-11-20
1000 Erschienen in
1000 Quellenangabe
  • 10(11):3397-3420
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.18632/aging.101655 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30472697/ |
1000 Ergänzendes Material
  • https://www.aging-us.com/article/101655/text#supplementarymaterials |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Replication-based telomere shortening during lifetime is species- and tissue-specific, however, its impact on healthy aging is unclear. In particular, the contribution of telomere truncation to the aging process of the CNS, where replicative senescence alone fails to explain organ aging due to low to absent mitotic activity of intrinsic populations, is undefined. Here, we assessed changes in relative telomere length in non-replicative and replicative neural brain populations and telomerase activity as a function of aging in C57BL/6 mice. Telomeres in neural cells and sub-selected neurons shortened with aging in a cell cycle-dependent and -independent manner, with preponderance in replicative moieties, implying that proliferation accelerates, but is not prerequisite for telomere shortening. Consistent with this telomere erosion, telomerase activity and nuclear TERT protein were not induced with aging. Knockdown of the Rela subunit of NF-κB, which controls both telomerase enzyme and subcellular TERT protein allocation, did also not influence telomerase activity or telomere length, in spite of its naive up-regulation selectively under aging conditions. We conclude that telomere instability is intrinsic to physiological brain aging beyond cell replication, and appears to occur independently of a functional interplay with NF-κB, but rather as a failure to induce or relocate telomerase.
1000 Sacherschließung
lokal telomerase reverse transcriptase
lokal cellular senescence
lokal RelA subunit of nuclear factor kappa B
lokal brain aging
lokal telomere length
lokal cell cycle
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QWluLCBRdWFydHVs|https://frl.publisso.de/adhoc/creator/U2NobWVlciwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/creator/UGVubmRvcmYsIERpYW5l|https://frl.publisso.de/adhoc/creator/RmlzY2hlciwgTWlrZQ==|https://frl.publisso.de/adhoc/creator/Qm9uZGV2YSwgVHp2ZXRhbmth|https://frl.publisso.de/adhoc/creator/RsO2cnN0ZXIsIE1hcnRpbg==|https://frl.publisso.de/adhoc/creator/SGFlbm9sZCwgUm9ubnk=|https://frl.publisso.de/adhoc/creator/V2l0dGUsIE90dG8gVy4=|https://frl.publisso.de/adhoc/creator/S3JldHosIEFsZXhhbmRyYQ==
1000 Label
1000 Förderer
  1. Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft |
  2. Friedrich-Schiller-Universität Jena |
  3. Universitätsklinikum Jena |
  4. Velux Stiftung |
1000 Fördernummer
  1. RegenerAging-52-5581-413-FSU-I-03/14
  2. -
  3. -
  4. -
1000 Förderprogramm
  1. ProExcellence Initiative RegenerAging
  2. Graduate Academy
  3. Interdisciplinary Centre for Clinical Research (IZKF)
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Thüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft |
    1000 Förderprogramm ProExcellence Initiative RegenerAging
    1000 Fördernummer RegenerAging-52-5581-413-FSU-I-03/14
  2. 1000 joinedFunding-child
    1000 Förderer Friedrich-Schiller-Universität Jena |
    1000 Förderprogramm Graduate Academy
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Universitätsklinikum Jena |
    1000 Förderprogramm Interdisciplinary Centre for Clinical Research (IZKF)
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Velux Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6413928.rdf
1000 Erstellt am 2019-04-10T14:09:33.885+0200
1000 Erstellt von 285
1000 beschreibt frl:6413928
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed May 29 12:10:25 CEST 2019
1000 Objekt bearb. Wed May 29 12:10:15 CEST 2019
1000 Vgl. frl:6413928
1000 Oai Id
  1. oai:frl.publisso.de:frl:6413928 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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