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WeightNameValue
1000 Titel
  • Inflammaging impairs peripheral nerve maintenance and regeneration
1000 Autor/in
  1. Büttner, Robert |
  2. Schulz, Alexander |
  3. Reuter, Michael |
  4. Akula, Asha K. |
  5. Mindos, Thomas |
  6. Carlstedt, Annemarie |
  7. Riecken, Lars Björn |
  8. Baader, Stephan L. |
  9. Bauer, Reinhard |
  10. Morrison, Helen |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-08-31
1000 Erschienen in
1000 Quellenangabe
  • 17(6):e12833
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1111/acel.12833 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30168637/ |
1000 Ergänzendes Material
  • https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12833#support-information-section |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The regenerative capacity of peripheral nerves declines during aging, contributing to the development of neuropathies, limiting organism function. Changes in Schwann cells prompt failures in instructing maintenance and regeneration of aging nerves; molecular mechanisms of which have yet to be delineated. Here, we identified an altered inflammatory environment leading to a defective Schwann cell response, as an underlying mechanism of impaired nerve regeneration during aging. Chronic inflammation was detected in intact uninjured old nerves, characterized by increased macrophage infiltration and raised levels of monocyte chemoattractant protein 1 (MCP1) and CC chemokine ligand 11 (CCL11). Schwann cells in the old nerves appeared partially dedifferentiated, accompanied by an activated repair program independent of injury. Upon sciatic nerve injury, an initial delayed immune response was followed by a persistent hyperinflammatory state accompanied by a diminished repair process. As a contributing factor to nerve aging, we showed that CCL11 interfered with Schwann cell differentiation in vitro and in vivo. Our results indicate that increased infiltration of macrophages and inflammatory signals diminish regenerative capacity of aging nerves by altering Schwann cell behavior. The study identifies CCL11 as a promising target for anti‐inflammatory therapies aiming to improve nerve regeneration in old age.
1000 Sacherschließung
lokal peripheral nervous system
lokal inflammaging
lokal neural regeneration
lokal macrophages
lokal aging
lokal schwann cell
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-4337-4251|https://orcid.org/0000-0003-1604-4596|https://frl.publisso.de/adhoc/creator/UmV1dGVyLCBNaWNoYWVs|https://frl.publisso.de/adhoc/creator/QWt1bGEsIEFzaGEgSy4=|https://orcid.org/0000-0003-0870-0696|https://frl.publisso.de/adhoc/creator/Q2FybHN0ZWR0LCBBbm5lbWFyaWU=|https://orcid.org/0000-0002-1992-4591|https://frl.publisso.de/adhoc/creator/QmFhZGVyLCBTdGVwaGFuIEwu|https://frl.publisso.de/adhoc/creator/QmF1ZXIsIFJlaW5oYXJk|https://orcid.org/0000-0003-4938-1409
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. GRK1715/1; MO1421/2-1
  2. SAW-2015-FLI-3
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
  1. Inflammaging impairs peripheral nerve maintenance and regeneration
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer GRK1715/1; MO1421/2-1
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SAW-2015-FLI-3
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6414362.rdf
1000 Erstellt am 2019-05-06T14:47:10.943+0200
1000 Erstellt von 285
1000 beschreibt frl:6414362
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Wed May 29 11:09:06 CEST 2019
1000 Objekt bearb. Wed May 29 11:08:46 CEST 2019
1000 Vgl. frl:6414362
1000 Oai Id
  1. oai:frl.publisso.de:frl:6414362 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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