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1000 Titel
  • Retinal S-opsin dominance in Ansell’s mole-rats (Fukomys anselli) is a consequence of naturally low serum thyroxine
1000 Autor/in
  1. Henning, Yoshiyuki |
  2. Mladěnková, Nella |
  3. Burda, Hynek |
  4. Szafranski, Karol |
  5. Begall, Sabine |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-03-12
1000 Erschienen in
1000 Quellenangabe
  • 8:4337
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-018-22705-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847620/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-018-22705-y#Sec20 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Mammals usually possess a majority of medium-wavelength sensitive (M-) and a minority of short-wavelength sensitive (S-) opsins in the retina, enabling dichromatic vision. Unexpectedly, subterranean rodents from the genus Fukomys exhibit an S-opsin majority, which is exceptional among mammals, albeit with no apparent adaptive value. Because thyroid hormones (THs) are pivotal for M-opsin expression and metabolic rate regulation, we have, for the first time, manipulated TH levels in the Ansell’s mole-rat (Fukomys anselli) using osmotic pumps. In Ansell’s mole-rats, the TH thyroxine (T4) is naturally low, likely as an adaptation to the harsh subterranean ecological conditions by keeping resting metabolic rate (RMR) low. We measured gene expression levels in the eye, RMR, and body mass (BM) in TH-treated animals. T4 treatment increased both, S- and M-opsin expression, albeit M-opsin expression at a higher degree. However, this plasticity was only given in animals up to approximately 2.5 years. Mass-specific RMR was not affected following T4 treatment, although BM decreased. Furthermore, the T4 inactivation rate is naturally higher in F. anselli compared to laboratory rodents. This is the first experimental evidence that the S-opsin majority in Ansell’s mole-rats is a side effect of low T4, which is downregulated to keep RMR low.
1000 Sacherschließung
lokal Zoology
lokal Thyroid gland
lokal Visual system
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/SGVubmluZywgWW9zaGl5dWtp|https://orcid.org/0000-0002-7343-354X|https://frl.publisso.de/adhoc/uri/QnVyZGEsIEh5bmVr|https://orcid.org/0000-0001-6391-1766|https://frl.publisso.de/adhoc/uri/QmVnYWxsLCBTYWJpbmU=
1000 Label
1000 Förderer
  1. Hanno & Gudrun Fiedler |
  2. Deutsche Forschungsgemeinschaft |
  3. Grantová Agentura České Republiky |
1000 Fördernummer
  1. -
  2. DA992/3-1
  3. 31-17-19896S
1000 Förderprogramm
  1. UDE scholarship
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Hanno & Gudrun Fiedler |
    1000 Förderprogramm UDE scholarship
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer DA992/3-1
  3. 1000 joinedFunding-child
    1000 Förderer Grantová Agentura České Republiky |
    1000 Förderprogramm -
    1000 Fördernummer 31-17-19896S
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6414556.rdf
1000 Erstellt am 2019-05-22T15:44:16.628+0200
1000 Erstellt von 285
1000 beschreibt frl:6414556
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Mon May 27 15:01:39 CEST 2019
1000 Objekt bearb. Mon May 27 15:00:32 CEST 2019
1000 Vgl. frl:6414556
1000 Oai Id
  1. oai:frl.publisso.de:frl:6414556 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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