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1000 Titel
  • Adaptive Evolution of the Eda Gene and Scales Loss in Schizothoracine Fishes in Response to Uplift of the Tibetan Plateau
1000 Autor/in
  1. Zhang, Cunfang |
  2. Tong, Chao |
  3. Ludwig, Arne |
  4. Tang, Yongtao |
  5. Liu, Sijia |
  6. Zhang, Renyi |
  7. Feng, Chenguang |
  8. Li, Guogang |
  9. Peng, Zuogang |
  10. Zhao, Kai |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-09-27
1000 Erschienen in
1000 Quellenangabe
  • 19(10):2953
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/ijms19102953 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213870/ |
1000 Ergänzendes Material
  • https://www.mdpi.com/1422-0067/19/10/2953#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Schizothoracine is the predominant wild fish subfamily of the Tibetan plateau (TP). Their scales, pharyngeal teeth and barbels have gradually regressed with increasing altitude. Schizothoracine have been divided into three groups: primitive, specialized and highly specialized. Ectodysplasin-A (Eda) has been considered as a major gene that contributes to the development of skin appendages. The present study cloned the Eda genes of 51 Schizothoracine fish species which represent the three groups and five Barbinae species. Phylogenetic analyses indicated that Eda may have acted as the genetic trigger for scale loss in the Schizothoracine. Furthermore, 14 single nucleotide polymorphisms (SNPs) and two deletions (18 bp and 6 bp in size), were also detected in the Eda coding sequence of the highly specialized group compared to the primitive group. The same SNPs and two indels result in four non-synonymous and two G-X-Y and 1 XY motif indels, which possibly contribute to significant structure changes in the Eda gene. The domain including (G-X-Y)n motif in the Eda gene is relatively conserved amongst teleosts. Based on the above results, we hypothesize that the evolution of Eda gene might be associated with the scale loss in Schizothoracine fishes in response to the phased uplift of the TP.
1000 Sacherschließung
lokal adaptive evolution
lokal Schizothoracine
lokal Eda gene
lokal Tibetan plateau
lokal scale loss
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-9170-0157|https://orcid.org/0000-0001-5202-5507|https://orcid.org/0000-0001-7249-9953|https://frl.publisso.de/adhoc/uri/VGFuZywgWW9uZ3Rhbw==|https://frl.publisso.de/adhoc/uri/TGl1LCBTaWppYQ==|https://frl.publisso.de/adhoc/uri/WmhhbmcsIFJlbnlp|https://frl.publisso.de/adhoc/uri/RmVuZywgQ2hlbmd1YW5n|https://frl.publisso.de/adhoc/uri/TGksIEd1b2dhbmc=|https://orcid.org/0000-0001-8810-2025|https://frl.publisso.de/adhoc/uri/WmhhbywgS2Fp
1000 Label
1000 Förderer
  1. National Natural Science Foundation of China |
  2. West Light Foundation of the Chinese Academy of Sciences |
1000 Fördernummer
  1. 31500306; 31572258; 31172070
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Natural Science Foundation of China |
    1000 Förderprogramm -
    1000 Fördernummer 31500306; 31572258; 31172070
  2. 1000 joinedFunding-child
    1000 Förderer West Light Foundation of the Chinese Academy of Sciences |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6415142.rdf
1000 Erstellt am 2019-07-12T11:47:35.151+0200
1000 Erstellt von 218
1000 beschreibt frl:6415142
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Thu Jan 30 22:31:55 CET 2020
1000 Objekt bearb. Mon Jul 29 10:51:26 CEST 2019
1000 Vgl. frl:6415142
1000 Oai Id
  1. oai:frl.publisso.de:frl:6415142 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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