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1000 Titel
  • Long-lived rodents reveal signatures of positive selection in genes associated with lifespan
1000 Autor/in
  1. Sahm, Arne |
  2. Bens, Martin |
  3. Szafranski, Karol |
  4. Holtze, Susanne |
  5. Groth, Marco |
  6. Görlach, Matthias |
  7. Calkhoven, Cornelis |
  8. Müller, Christine |
  9. Schwab, Matthias |
  10. Kraus, Johann |
  11. Kestler, Hans |
  12. Cellerino, Alessandro |
  13. Burda, Hynek |
  14. Hildebrandt, Thomas Bernd |
  15. Dammann, Philip |
  16. Platzer, Matthias |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-03-23
1000 Erschienen in
1000 Quellenangabe
  • 14(3):e1007272
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pgen.1007272 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884551/ |
1000 Ergänzendes Material
  • https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007272#sec018 |
  • https://doi.org/10.5061/dryad.75b406n |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The genetics of lifespan determination is poorly understood. Most research has been done on short-lived animals and it is unclear if these insights can be transferred to long-lived mammals like humans. Some African mole-rats (Bathyergidae) have life expectancies that are multiple times higher than similar sized and phylogenetically closely related rodents. To gain new insights into genetic mechanisms determining mammalian lifespans, we obtained genomic and transcriptomic data from 17 rodent species and scanned eleven evolutionary branches associated with the evolution of enhanced longevity for positively selected genes (PSGs). Indicating relevance for aging, the set of 250 identified PSGs showed in liver of long-lived naked mole-rats and short-lived rats an expression pattern that fits the antagonistic pleiotropy theory of aging. Moreover, we found the PSGs to be enriched for genes known to be related to aging. Among these enrichments were “cellular respiration” and “metal ion homeostasis”, as well as functional terms associated with processes regulated by the mTOR pathway: translation, autophagy and inflammation. Remarkably, among PSGs are RHEB, a regulator of mTOR, and IGF1, both central components of aging-relevant pathways, as well as genes yet unknown to be aging-associated but representing convincing functional candidates, e.g. RHEBL1, AMHR2, PSMG1 and AGER. Exemplary protein homology modeling suggests functional consequences for amino acid changes under positive selection. Therefore, we conclude that our results provide a meaningful resource for follow-up studies to mechanistically link identified genes and amino acids under positive selection to aging and lifespan determination.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2FobSwgQXJuZQ==|https://orcid.org/0000-0001-7940-6668|https://frl.publisso.de/adhoc/uri/U3phZnJhbnNraSwgS2Fyb2w=|https://frl.publisso.de/adhoc/uri/SG9sdHplLCBTdXNhbm5l|https://orcid.org/0000-0002-9199-8990|https://frl.publisso.de/adhoc/uri/R8O2cmxhY2gsIE1hdHRoaWFz|https://frl.publisso.de/adhoc/uri/Q2Fsa2hvdmVuLCBDb3JuZWxpcw==|https://frl.publisso.de/adhoc/uri/TcO8bGxlciwgQ2hyaXN0aW5l|https://frl.publisso.de/adhoc/uri/U2Nod2FiLCBNYXR0aGlhcw==|https://frl.publisso.de/adhoc/uri/S3JhdXMsIEpvaGFubg==|https://orcid.org/0000-0002-4759-5254|https://orcid.org/0000-0003-3834-0097|https://frl.publisso.de/adhoc/uri/QnVyZGEsIEh5bmVr|https://frl.publisso.de/adhoc/uri/SGlsZGVicmFuZHQsIFRob21hcyBCZXJuZA==|https://frl.publisso.de/adhoc/uri/RGFtbWFubiwgUGhpbGlw|https://orcid.org/0000-0003-0596-8582
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Seventh Framework Programme |
  3. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. PL 173/8-1; DA 992/3-1
  2. FP7-HEALTH-2012-279281
  3. SAW-2012-FLI-2
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer PL 173/8-1; DA 992/3-1
  2. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer FP7-HEALTH-2012-279281
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SAW-2012-FLI-2
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6415199.rdf
1000 Erstellt am 2019-07-16T10:52:43.871+0200
1000 Erstellt von 218
1000 beschreibt frl:6415199
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Mon Jul 29 12:50:13 CEST 2019
1000 Objekt bearb. Mon Jul 29 12:50:13 CEST 2019
1000 Vgl. frl:6415199
1000 Oai Id
  1. oai:frl.publisso.de:frl:6415199 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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