Download
s12970-018-0234-y.pdf 1,73MB
WeightNameValue
1000 Titel
  • Low-fat diet, and medium-fat diets containing coconut oil and soybean oil exert different metabolic effects in untrained and treadmill-trained mice
1000 Autor/in
  1. Manio, Mark Christian |
  2. Matsumura, Shigenobu |
  3. Inoue, Kazuo |
1000 Erscheinungsjahr 2018
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-06-18
1000 Erschienen in
1000 Quellenangabe
  • 15:29
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12970-018-0234-y |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006686/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Diets containing fats of different proportions and types have been demonstrated to influence metabolism. These fats differ in long chain fatty acids (LCFAs) or medium chain fatty acids (MCFAs) content. In our laboratory using swimming as the training modality, MCFAs increased endurance attributed to increased activities of oxidative enzymes. How it affects whole-body metabolism remains unexplored. The present study investigated the metabolic, biochemical and genetic adaptations with treadmill running as the training modality. METHODS: C57BL/6N mice were divided into untrained and trained groups and provided with low-fat (10% kcal from soybean oil), coconut oil (10% kcal from soybean oil, 20% kcal from coconut oil) or soybean oil (30% kcal from soybean oil) diet. Training was performed on a treadmill for 30 days. After recovery, whole-body metabolism at rest and during exercise, endurance, substrate metabolism, mitochondrial enzyme activities, and gene expression of training-adaptive genes in the muscle and liver were measured. RESULTS: At rest, medium-fat diets decreased respiratory exchange ratio (RER) (p < 0.05). Training increased RER in all diet groups without affecting oxygen consumption (p < 0.05). During exercise, diets had no overt effects on metabolism while training decreased oxygen consumption indicating decreased energy expenditure (p < 0.05). Coconut oil without training improved endurance based on work (p < 0.05). Training improved all endurance parameters without overt effects of diet (p < 0.05). Moreover, training increased the activities of mitochondrial enzymes likely related to the increased expression of estrogen related receptor (ERR) α and ERRβ (p < 0.05). Coconut oil inhibited peroxisome proliferator-activated receptor (PPAR) β/δ activation and glycogen accumulation in the muscle but activated PPARα in the liver in the trained state (p < 0.05). Substrate utilization data suggested that coconut oil and/or resulting ketone bodies spared glycogen utilization in the trained muscle during exercise thereby preserving endurance. CONCLUSION: Our data demonstrated the various roles of diet and fat types in training adaptation. Diets exerted different roles in PPAR activation and substrate handling in the context of endurance exercise training. However, the role of fat types in training adaptations is limited as training overwhelms and normalizes the effects of diet in the untrained state particularly on endurance performance, mitochondrial biogenesis, and ERR expression.
1000 Sacherschließung
lokal Mitochondria
lokal Low-fat diet
lokal Treadmill exercise
lokal Training-adaptation
lokal Coconut oil
lokal Glycogen
lokal Endurance
lokal Metabolism
lokal Soybean oil
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWFuaW8sIE1hcmsgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/TWF0c3VtdXJhLCBTaGlnZW5vYnU=|https://frl.publisso.de/adhoc/uri/SW5vdWUsIEthenVv
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6416588.rdf
1000 Erstellt am 2019-10-02T12:17:25.449+0200
1000 Erstellt von 218
1000 beschreibt frl:6416588
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 17:35:18 CET 2020
1000 Objekt bearb. Wed Oct 02 12:24:19 CEST 2019
1000 Vgl. frl:6416588
1000 Oai Id
  1. oai:frl.publisso.de:frl:6416588 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source