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WeightNameValue
1000 Titel
  • Quality of life in a German cohort of Parkinson’s patients assessed with three different measures
1000 Autor/in
  1. Balzer-Geldsetzer, Monika |
  2. Klotsche, Jens |
  3. Dodel, Richard |
  4. Riedel, Oliver |
1000 Mitwirkende/r
  1. LANDSCAPE Consortium |
1000 Erscheinungsjahr 2018
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-09-12
1000 Erschienen in
1000 Quellenangabe
  • 265(11):2713-2722
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Embargo
  • 2019-09-12
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00415-018-9047-9 |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007%2Fs00415-018-9047-9#SupplementaryMaterial |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Parkinson’s disease (PD) is characterized by severe motor and non-motor symptoms reducing patients’ quality of life (QoL). Instruments have been well established for QoL assessments in PD, including the EuroQol (EQ-5D), the Parkinson’s disease questionnaire (PDQ-39), or rather uncommon, like the WHOQOL-100. So far, the impact of variables has been investigated for each of these measures separately in different study populations, limiting the comparability of the results. Thus, this study compared the EQ-5D, PDQ-39, and the WHOQOL-100 (with its short-form WHOQOL-BREF) in the same study population. METHODS: Seventy-five PD outpatients were assessed in a prospective study, including disease severity according to Hoehn and Yahr stage (HY) and Unified Parkinson Disease Rating Scale (UPDRS). The Geriatric Depression Scale (GDS-15) screened for depression. RESULTS: Decreased QoL was found with all three instruments. In multivariate models, sex and treatment complications had an impact on QoL according to all three measures, while duration of PD and HY was not associated with QoL in any of them. Depression was relevant for the WHOQOL-100/WHOQOL-BREF and the PDQ-39, but not for the EQ-5D. The total variances explained by the WHOQOL-100, WHOQOL-BREF, PDQ-39, and the EQ-5D were 0.27, 0.34, 0.70, and 0.50, respectively. CONCLUSIONS: The associations between clinical aspects of PD and QoL vary substantially among all three measures. Importantly, depression as a frequent comorbidity in PD is underestimated by the EQ-5D, but not by the PDQ-39 and the WHOQOL-100/WHOQOL-BREF. In turn, motor impairments are underestimated by the latter and associated strongest with QoL in the EQ-5D.
1000 Sacherschließung
lokal Quality of life
lokal Cohort study
lokal WHOQOL-100
lokal DEMPARK/LANDSCAPE study
lokal Parkinson’s disease
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QmFsemVyLUdlbGRzZXR6ZXIsIE1vbmlrYQ==|https://frl.publisso.de/adhoc/uri/S2xvdHNjaGUsIEplbnM=|https://frl.publisso.de/adhoc/uri/RG9kZWwsIFJpY2hhcmQ=|https://orcid.org/0000-0002-1721-502X|https://frl.publisso.de/adhoc/uri/TEFORFNDQVBFIENvbnNvcnRpdW0=
1000 Label
1000 Förderer
  1. Bundesministerium für Bildung und Forschung |
1000 Fördernummer
  1. 01GI1008C
1000 Förderprogramm
  1. -
1000 Dateien
  1. Nutzungsvereinbarung
  2. Springer Self-archiving Policy
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer 01GI1008C
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6417061.rdf
1000 Erstellt am 2019-10-24T12:27:20.342+0200
1000 Erstellt von 266
1000 beschreibt frl:6417061
1000 Bearbeitet von 16
1000 Zuletzt bearbeitet Thu Mar 05 06:57:29 CET 2020
1000 Objekt bearb. Thu Mar 05 06:57:29 CET 2020
1000 Vgl. frl:6417061
1000 Oai Id
  1. oai:frl.publisso.de:frl:6417061 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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