An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial

  1. Karusheva, Yanislava
  2. Kunstein, Lejla
  3. Bierwagen, Alessandra ORCID logo
  4. Nowotny, Bettina
  5. Kabisch, Stefan
  6. Groener, Jan B.
  7. Fleitmann, Ann Kristin
  8. Herder, Christian ORCID logo
  9. Pacini, Giovanni
  10. Strassburger, Klaus
  11. Häring, Hans-Ulrich
  12. Nawroth, Peter P.
  13. Pfeiffer, Andreas F. H.
  14. Burkart, Volker
  15. Müssig, Karsten
  16. Roden, Michael
  17. Szendroedi, Julia ORCID logo

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1000 Titel
  • An 8-week diet high in cereal fiber and coffee but free of red meat does not improve beta-cell function in patients with type 2 diabetes mellitus: a randomized controlled trial
1000 Autor/in
  1. Karusheva, Yanislava |
  2. Kunstein, Lejla |
  3. Bierwagen, Alessandra |
  4. Nowotny, Bettina |
  5. Kabisch, Stefan |
  6. Groener, Jan B. |
  7. Fleitmann, Ann Kristin |
  8. Herder, Christian |
  9. Pacini, Giovanni |
  10. Strassburger, Klaus |
  11. Häring, Hans-Ulrich |
  12. Nawroth, Peter P. |
  13. Pfeiffer, Andreas F. H. |
  14. Burkart, Volker |
  15. Müssig, Karsten |
  16. Roden, Michael |
  17. Szendroedi, Julia |
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-12-29
1000 Erschienen in
1000 Quellenangabe
  • 15:90
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12986-018-0324-5 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311026/ |
1000 Ergänzendes Material
  • https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0324-5#Sec16 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. METHODS: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat (n = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat (n = 20) (H-RISK) for 8 weeks. Insulin secretion was assessed from glucagon stimulation tests (GST) and mixed-meal tolerance tests (MMTT) before and after dietary intervention. RESULTS: Both diets resulted in comparable reduction of fasting concentrations of insulin (H-RISK -28% vs. L-RISK -32%, both p < 0.01), C-peptide (H-RISK -26% vs. L-RISK -30%, both p < 0.01) and blood glucose (H-RISK -6.8%, p < 0.05 vs. L-RISK -10%, p < 0.01). Gastric inhibitory peptide (GIP) secretion increased by 24% after 8 weeks in the L-RISK only (p < 0.01). However, GST and MMTT showed no differences in insulin secretion after intervention. CONCLUSIONS: Calorie restriction independent of the intake of fiber, coffee or meat failed to improve beta-cell function, but improved GIP secretion in obese patients with type 2 diabetes. TRIAL REGISTRATION: Registration at Clinicaltrials.gov, Identifier number: NCT01409330, Registered 4 August 2011 – Retrospectively registered.
1000 Sacherschließung
lokal Dietary fiber
lokal Beta-cell function
lokal Coffee
lokal Red meat
lokal Calorie restriction
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S2FydXNoZXZhLCBZYW5pc2xhdmE=|https://frl.publisso.de/adhoc/uri/S3Vuc3RlaW4sIExlamxh|https://orcid.org/0000-0003-0419-2436|https://frl.publisso.de/adhoc/uri/Tm93b3RueSwgQmV0dGluYQ==|https://frl.publisso.de/adhoc/uri/S2FiaXNjaCwgU3RlZmFu|https://frl.publisso.de/adhoc/uri/R3JvZW5lciwgSmFuIEIu|https://frl.publisso.de/adhoc/uri/RmxlaXRtYW5uLCBBbm4gS3Jpc3Rpbg==|https://orcid.org/0000-0002-2050-093X|https://frl.publisso.de/adhoc/uri/UGFjaW5pLCBHaW92YW5uaQ==|https://frl.publisso.de/adhoc/uri/U3RyYXNzYnVyZ2VyLCBLbGF1cw==|https://frl.publisso.de/adhoc/uri/SMOkcmluZywgSGFucy1VbHJpY2g=|https://frl.publisso.de/adhoc/uri/TmF3cm90aCwgUGV0ZXIgUC4=|https://frl.publisso.de/adhoc/uri/UGZlaWZmZXIsIEFuZHJlYXMgRi4gSC4=|https://frl.publisso.de/adhoc/uri/QnVya2FydCwgVm9sa2Vy|https://frl.publisso.de/adhoc/uri/TcO8c3NpZywgS2Fyc3Rlbg==|http://d-nb.info/gnd/130812773|https://orcid.org/0000-0002-5185-8168
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  1. Bundesministerium für Gesundheit |
  2. Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen |
  3. Bundesministerium für Bildung und Forschung |
  4. Helmholtz-Allianz ICEMED |
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  2. 1000 joinedFunding-child
    1000 Förderer Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen |
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    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
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