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1000 Titel
  • Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults
1000 Autor/in
  1. Luo, Jing |
  2. Chen, Qian |
  3. Shen, Tianran |
  4. Wang, Xu |
  5. Fang, Wanjun |
  6. Wu, Xiaocai |
  7. Yuan, Zenan |
  8. Chen, Gengdong |
  9. Ling, Wenhua |
  10. Chen, Yuming |
1000 Erscheinungsjahr 2018
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2018-11-08
1000 Erschienen in
1000 Quellenangabe
  • 15:79
1000 Copyrightjahr
  • 2018
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1186/s12986-018-0313-8 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225668/ |
1000 Ergänzendes Material
  • https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0313-8#Sec19 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Sex hormone-binding globulin (SHBG), a glycoprotein synthesized by hepatocytes, has been linked to insulin resistance and hepatic lipid metabolism and is suggested to be associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the association of SHBG with NAFLD in Chinese adults. METHODS: We conducted a community-based, cross-sectional study in China involving 2912 participants aged 40–75 years old. All participants underwent detection for hepatic fat infiltration by ultrasound in addition to providing complete medical history and undergoing physical and blood biochemical examinations. The association of serum SHBG with the presence of NAFLD was reported by adjusted odds ratio after applying logistic regression models. To further explore the relationship between SHBG and NAFLD, mRNA expression of SHBG and hepatocyte nuclear factor 4-α (HNF4α), as well as intrahepatic triglycerides, were determined from the liver tissues of 32 subjects with different degrees of steatosis. RESULTS: Serum SHBG levels in patients with NAFLD (median, 43.8 nmol/L; interquartile range, 33.4–56.8 nmol/L) were significantly lower than those in non-NAFLD subjects (median, 63.4 nmol/L; interquartile range, 47.6–83.1 nmol/L). Serum SHBG levels were inversely correlated with WHR, trunk fat percentage, glucose, HOMA-IR, TG, UA and DHEAS, and were positively correlated with HDL-C levels (all p <  0.001). Logistic regression analysis indicated that serum SHBG levels were negatively associated with the presence of NAFLD in all subjects, as well as the subgroups stratified by sex, BMI and HOMA-IR (all p <  0.05). In human liver tissues, SHBG and HNF4α mRNA expression decreased along with the elevated grade of hepatic steatosis. Both SHBG and HNF4α mRNA expression levels were negatively correlated with intrahepatic triglycerides. CONCLUSIONS: These results demonstrate that SHBG levels were negatively associated with the presence of NAFLD in middle-aged and elderly Chinese adults.
1000 Sacherschließung
lokal Hepatic steatosis
lokal Nonalcoholic fatty liver disease
lokal Sex hormone-binding globulin
lokal Intrahepatic triglyceride
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/THVvLCBKaW5n|https://frl.publisso.de/adhoc/uri/Q2hlbiwgUWlhbg==|https://frl.publisso.de/adhoc/uri/U2hlbiwgVGlhbnJhbg==|https://frl.publisso.de/adhoc/uri/V2FuZywgWHU=|https://frl.publisso.de/adhoc/uri/RmFuZywgV2FuanVu|https://frl.publisso.de/adhoc/uri/V3UsIFhpYW9jYWk=|https://frl.publisso.de/adhoc/uri/WXVhbiwgWmVuYW4=|https://frl.publisso.de/adhoc/uri/Q2hlbiwgR2VuZ2Rvbmc=|https://orcid.org/0000-0002-5468-6605|https://frl.publisso.de/adhoc/uri/Q2hlbiwgWXVtaW5n
1000 Label
1000 Förderer
  1. Guangzhou Municipal Science and Technology Project |
1000 Fördernummer
  1. 42050027
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Guangzhou Municipal Science and Technology Project |
    1000 Förderprogramm -
    1000 Fördernummer 42050027
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6417267.rdf
1000 Erstellt am 2019-11-05T15:22:46.752+0100
1000 Erstellt von 218
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1000 Zuletzt bearbeitet Thu Jan 30 19:58:57 CET 2020
1000 Objekt bearb. Tue Nov 05 15:28:00 CET 2019
1000 Vgl. frl:6417267
1000 Oai Id
  1. oai:frl.publisso.de:frl:6417267 |
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