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WeightNameValue
1000 Titel
  • Identification of cross‐reactive antibodies for the detection of lymphocytes, myeloid cells and haematopoietic precursors in the naked mole rat
1000 Autor/in
  1. Shebzukhov, Yury |
  2. Holtze, Susanne |
  3. Hirseland, Heike |
  4. Schäfer, Hubert |
  5. Radbruch, Andreas |
  6. Hildebrandt, Thomas Bernd |
  7. Grützkau, Andreas |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-07-26
1000 Erschienen in
1000 Quellenangabe
  • 49(11):2103-2110
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/eji.201948124 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163560 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163560/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The naked mole rat (Heterocephalus glaber, NMR) is a rodent with exceptional longevity, low rates of age‐related diseases and spontaneous carcinogenesis. The NMR represents an attractive animal model in longevity and cancer research, but there are no NMR‐specific antibodies available to study its immune system with respect to age‐ and cancer‐related questions. Substantial homology of major NMR immune cell markers with those of Guinea pig, human and, to a lesser extent, mouse and rat origin are implicated for the existence of immunological cross‐reactivity. We identified 10 antibodies recognising eight immunophenotypic markers expressed on the NMR's T and B lymphocytes, macrophages/monocytes and putative haematopoietic precursors and used them for an immunophenotyping of leukocyte subsets of peripheral blood, spleen and bone marrow samples. Overall, we found that the leukocyte composition of NMR peripheral blood is comparable to that of mice. Notably, the frequency of cytotoxic T cells was found to be lower in the NMR compared to corresponding mouse tissues and human blood. Antibodies used in the present paper are available either commercially or from the scientific community and will provide new opportunities for the NMR as a model system in ageing‐ and cancer‐related research areas.
1000 Sacherschließung
lokal lymphocytes
lokal myeloid cells
lokal granulocytes
lokal haematopoietic precursors
lokal naked mole rat
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/U2hlYnp1a2hvdiwgWXVyeQ==|https://orcid.org/0000-0002-4654-1916|https://frl.publisso.de/adhoc/uri/SGlyc2VsYW5kLCBIZWlrZQ==|https://frl.publisso.de/adhoc/uri/U2Now6RmZXIsIEh1YmVydA==|https://frl.publisso.de/adhoc/uri/UmFkYnJ1Y2gsIEFuZHJlYXM=|https://orcid.org/0000-0001-8685-4733|https://frl.publisso.de/adhoc/uri/R3LDvHR6a2F1LCBBbmRyZWFz
1000 Label
1000 Förderer
  1. Leibniz-Gemeinschaft |
  2. Russian Foundation for Basic Research |
1000 Fördernummer
  1. -
  2. # 17‐04‐02112
1000 Förderprogramm
  1. Leibniz Science Campus Chronic Inflammation
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm Leibniz Science Campus Chronic Inflammation
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Russian Foundation for Basic Research |
    1000 Förderprogramm -
    1000 Fördernummer # 17‐04‐02112
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6419342.rdf
1000 Erstellt am 2020-03-25T15:29:24.643+0100
1000 Erstellt von 122
1000 beschreibt frl:6419342
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 15 16:00:49 CEST 2022
1000 Objekt bearb. Wed Jun 15 16:00:48 CEST 2022
1000 Vgl. frl:6419342
1000 Oai Id
  1. oai:frl.publisso.de:frl:6419342 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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