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Nagrani-et-al_2020_Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome.pdf 3,28MB
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1000 Titel
  • Common genetic variation in obesity, lipid transfer genes and risk of Metabolic Syndrome: Results from IDEFICS/I.Family study and meta-analysis
1000 Autor/in
  1. nagrani, rajini |
  2. Foraita, Ronja |
  3. Gianfagna, Francesco |
  4. Iacoviello, Licia |
  5. Mårild, Staffan |
  6. Michels, Nathalie |
  7. Molnár, Dénes |
  8. Moreno, Luis A. |
  9. Russo, Paola |
  10. Veidebaum, Toomas |
  11. Ahrens, Wolfgang |
  12. Marron, Manuela |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-04-28
1000 Erschienen in
1000 Quellenangabe
  • 10:7189
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-020-64031-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188794/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-020-64031-2#Sec14 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • As the prevalence of metabolic syndrome (MetS) in children and young adults is increasing, a better understanding of genetics that underlie MetS will provide critical insights into the origin of the disease. We examined associations of common genetic variants and repeated MetS score from early childhood to adolescence in a pan-European, prospective IDEFICS/I.Family cohort study with baseline survey and follow-up examinations after two and six years. We tested associations in 3067 children using a linear mixed model and confirmed the results with meta-analysis of identified SNPs. With a stringent Bonferroni adjustment for multiple comparisons we obtained significant associations(p < 1.4 × 10−4) for 5 SNPs, which were in high LD (r2 > 0.85) in the 16q12.2 non-coding intronic chromosomal region of FTO gene with strongest association observed for rs8050136 (effect size(β) = 0.31, pWald = 1.52 × 10−5). We also observed a strong association of rs708272 in CETP with increased HDL (p = 5.63 × 10−40) and decreased TRG (p = 9.60 × 10−5) levels. These findings along with meta-analysis advance etiologic understanding of childhood MetS, highlighting that genetic predisposition to MetS is largely driven by genes of obesity and lipid metabolism. Inclusion of the associated genetic variants in polygenic scores for MetS may prove to be fundamental for identifying children and subsequently adults of the high-risk group to allow earlier targeted interventions.
1000 Sacherschließung
lokal Genetic association study
lokal Metabolic disorders
lokal Diagnostic markers
lokal Risk factors
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-1708-2319|https://orcid.org/0000-0003-2216-6653|https://frl.publisso.de/adhoc/uri/R2lhbmZhZ25hLCBGcmFuY2VzY28=|https://frl.publisso.de/adhoc/uri/SWFjb3ZpZWxsbywgTGljaWE=|https://frl.publisso.de/adhoc/uri/TcOlcmlsZCwgU3RhZmZhbg==|https://frl.publisso.de/adhoc/uri/TWljaGVscywgTmF0aGFsaWU=|https://frl.publisso.de/adhoc/uri/TW9sbsOhciwgRMOpbmVz|https://frl.publisso.de/adhoc/uri/TW9yZW5vLCBMdWlzIEEu|https://frl.publisso.de/adhoc/uri/UnVzc28sIFBhb2xh|https://frl.publisso.de/adhoc/uri/VmVpZGViYXVtLCBUb29tYXM=|https://orcid.org/0000-0003-3777-570X|https://frl.publisso.de/adhoc/uri/TWFycm9uLCBNYW51ZWxh
1000 Label
1000 Förderer
  1. Sixth Framework Programme |
  2. Seventh Framework Programme |
  3. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. 016181 (FOOD)
  2. 266044
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Sixth Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 016181 (FOOD)
  2. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 266044
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6420650.rdf
1000 Erstellt am 2020-05-07T12:58:18.830+0200
1000 Erstellt von 266
1000 beschreibt frl:6420650
1000 Bearbeitet von 266
1000 Zuletzt bearbeitet Mon Sep 28 15:13:13 CEST 2020
1000 Objekt bearb. Mon Sep 28 15:13:13 CEST 2020
1000 Vgl. frl:6420650
1000 Oai Id
  1. oai:frl.publisso.de:frl:6420650 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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