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1000 Titel
  • Potential selection effects when estimating associations between the infancy peak or adiposity rebound and later body mass index in children
1000 Autor/in
  1. Börnhorst, Claudia |
  2. Siani, Alfonso |
  3. Tornaritis, Michael |
  4. Molnár, Dénes |
  5. Lissner, Lauren |
  6. Regber, Susann |
  7. Reisch, Lucia A. |
  8. De Decker, Annelies |
  9. Moreno, Luis A. |
  10. Ahrens, Wolfgang |
  11. Pigeot, Iris |
1000 Mitwirkende/r
  1. The IDEFICS consortium |
  2. The I.Family consortium |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-11-30
1000 Erschienen in
1000 Quellenangabe
  • 41:518-526
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Embargo
  • 2017-11-30
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/ijo.2016.218 |
1000 Ergänzendes Material
  • https://www.nature.com/articles/ijo2016218#Sec12 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: This study aims to evaluate a potential selection effect caused by exclusion of children with non-identifiable infancy peak (IP) and adiposity rebound (AR) when estimating associations between age and body mass index (BMI) at IP and AR and later weight status. SUBJECTS AND METHODS: In 4744 children with at least 4 repeated measurements of height and weight in the age interval from 0 to 8 years (37 998 measurements) participating in the IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants)/I.Family cohort study, fractional polynomial multilevel models were used to derive individual BMI trajectories. Based on these trajectories, age and BMI at IP and AR, BMI values and growth velocities at selected ages as well as the area under the BMI curve were estimated. The BMI growth measures were standardized and related to later BMI z-scores (mean age at outcome assessment: 9.2 years). RESULTS: Age and BMI at IP and AR were not identifiable in 5.4% and 7.8% of the children, respectively. These groups of children showed a significantly higher BMI growth during infancy and childhood. In the remaining sample, BMI at IP correlated almost perfectly (r⩾0.99) with BMI at ages 0.5, 1 and 1.5 years, whereas BMI at AR correlated perfectly with BMI at ages 4–6 years (r⩾0.98). In the total study group, BMI values in infancy and childhood were positively associated with later BMI z-scores where associations increased with age. Associations between BMI velocities and later BMI z-scores were largest at ages 5 and 6 years. Results differed for children with non-identifiable IP and AR, demonstrating a selection effect. CONCLUSIONS: IP and AR may not be estimable in children with higher-than-average BMI growth. Excluding these children from analyses may result in a selection bias that distorts effect estimates. BMI values at ages 1 and 5 years might be more appropriate to use as predictors for later weight status instead.
1000 Sacherschließung
lokal Epidemiology
lokal Obesity
lokal Paediatric research
lokal Body mass index
lokal Risk factors
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-9004-1540|https://orcid.org/0000-0002-9797-2943|https://frl.publisso.de/adhoc/uri/VG9ybmFyaXRpcywgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/TW9sbsOhciwgRMOpbmVz|https://frl.publisso.de/adhoc/uri/TGlzc25lciwgTGF1cmVu|https://frl.publisso.de/adhoc/uri/UmVnYmVyLCBTdXNhbm4=|https://frl.publisso.de/adhoc/uri/UmVpc2NoLCBMdWNpYSBBLg==|https://orcid.org/0000-0002-9287-6813|https://frl.publisso.de/adhoc/uri/TW9yZW5vLCBMdWlzIEEu|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0001-7483-0726|https://frl.publisso.de/adhoc/uri/VGhlIElERUZJQ1MgY29uc29ydGl1bQ==|https://frl.publisso.de/adhoc/uri/VGhlIEkuRmFtaWx5IGNvbnNvcnRpdW0=
1000 Label
1000 Förderer
  1. Sixth Framework Programme |
  2. Seventh Framework Programme |
1000 Fördernummer
  1. 016181 (FOOD)
  2. 266044
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
  1. Nutzungsvereinbarung
  2. Springer_self-archiving-policy
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Sixth Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 016181 (FOOD)
  2. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 266044
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6421459.rdf
1000 Erstellt am 2020-06-22T13:58:01.014+0200
1000 Erstellt von 266
1000 beschreibt frl:6421459
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Tue Jul 14 06:50:12 CEST 2020
1000 Objekt bearb. Tue Jul 14 06:50:11 CEST 2020
1000 Vgl. frl:6421459
1000 Oai Id
  1. oai:frl.publisso.de:frl:6421459 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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