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WeightNameValue
1000 Titel
  • Associations between early body mass index trajectories and later metabolic risk factors in European children: the IDEFICS study
1000 Autor/in
  1. Börnhorst, Claudia |
  2. Tilling, Kate |
  3. Russo, Paola |
  4. Kourides, Yiannis |
  5. Michels, Nathalie |
  6. Molnár, Dénes |
  7. Rodríguez, Gerardo |
  8. Moreno, Luis A. |
  9. Krogh, Vittorio |
  10. Ben-Shlomo, Yoav |
  11. Ahrens, Wolfgang |
  12. Pigeot, Iris |
1000 Mitwirkende/r
  1. The IDEFICS consortium |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-08-22
1000 Erschienen in
1000 Quellenangabe
  • 31:513-525
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Embargo
  • 2016-08-22
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10654-015-0080-z |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007%2Fs10654-015-0080-z#Sec16 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Faster growth seems to be a common factor in several hypotheses relating early life exposures to subsequent health. This study aims to investigate the association between body mass index (BMI) trajectories during infancy/childhood and later metabolic risk in order to identify sensitive periods of growth affecting health. In a first step, BMI trajectories of 3301 European children that participated in the multi-centre Identification and Prevention of Dietary and Lifestyle-induced Health Effects in Children and Infants (IDEFICS) study were modelled using linear-spline mixed-effects models. The estimated random coefficients indicating initial subject-specific BMI and rates of change in BMI over time were used as exposure variables in a second step and related to a metabolic syndrome (MetS) score and its single components based on conditional regression models (mean age at outcome assessment: 8.5 years). All exposures under investigation, i.e. BMI at birth, rates of BMI change during infancy (0 to <9 months), early childhood (9 months to <6 years) and later childhood (≥6 years) as well as current BMI z-score were significantly associated with the later MetS score. Associations were strongest for the rate of BMI change in early childhood (1.78 [1.66; 1.90]; β estimate and 99 % confidence interval) and current BMI z-score (1.16 [0.96; 1.38]) and less pronounced for BMI at birth (0.62 [0.47; 0.78]). Results slightly differed with regard to the single metabolic factors. Starting from birth rapid BMI growth, especially in the time window of 9 months to <6 years, is significantly related to later metabolic risk in children. Much of the associations of early BMI growth may further be mediated through the effects on subsequent BMI growth.
1000 Sacherschließung
lokal IDEFICS study
lokal Metabolic risk score
lokal Childhood BMI growth
lokal Linear-spline mixed-effects model
lokal Data reduction
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7587-603X|https://frl.publisso.de/adhoc/uri/VGlsbGluZywgS2F0ZQ==|https://frl.publisso.de/adhoc/uri/UnVzc28sIFBhb2xh|https://frl.publisso.de/adhoc/uri/S291cmlkZXMsIFlpYW5uaXM=|https://frl.publisso.de/adhoc/uri/TWljaGVscywgTmF0aGFsaWU=|https://frl.publisso.de/adhoc/uri/TW9sbsOhciwgRMOpbmVz|https://frl.publisso.de/adhoc/uri/Um9kcsOtZ3VleiwgR2VyYXJkbw==|https://frl.publisso.de/adhoc/uri/TW9yZW5vLCBMdWlzIEEu|https://frl.publisso.de/adhoc/uri/S3JvZ2gsIFZpdHRvcmlv|https://frl.publisso.de/adhoc/uri/QmVuLVNobG9tbywgWW9hdg==|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0001-7483-0726|https://frl.publisso.de/adhoc/uri/VGhlIElERUZJQ1MgY29uc29ydGl1bQ==
1000 Label
1000 Förderer
  1. Sixth Framework Programme |
1000 Fördernummer
  1. 016181 (FOOD)
1000 Förderprogramm
  1. -
1000 Dateien
  1. Nutzungsvereinbarung
  2. Springer_self-archiving-policy
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Sixth Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 016181 (FOOD)
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6421460.rdf
1000 Erstellt am 2020-06-22T14:05:21.488+0200
1000 Erstellt von 266
1000 beschreibt frl:6421460
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Tue Jul 14 06:52:46 CEST 2020
1000 Objekt bearb. Tue Jul 14 06:52:45 CEST 2020
1000 Vgl. frl:6421460
1000 Oai Id
  1. oai:frl.publisso.de:frl:6421460 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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