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Pisa-et-al_2020_Individual Antidepressants and the Risk of Fractures in Older Adults_A New User Active Comparator Study.pdf 1,80MB
WeightNameValue
1000 Titel
  • Individual Antidepressants and the Risk of Fractures in Older Adults: A New User Active Comparator Study
1000 Autor/in
  1. Pisa, Federica Edith |
  2. Reinold, Jonas |
  3. Kollhorst, Bianca |
  4. Haug, Ulrike |
  5. Schink, Tania |
1000 Erscheinungsjahr 2020
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-22
1000 Erschienen in
1000 Quellenangabe
  • 12:667-678
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.2147/CLEP.S222888 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319507/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVE: To determine the risk of hip–pelvis and other non-vertebral fractures in older adults using antidepressants (ADs). METHODS: We conducted a case–control study nested in a cohort of new users of ADs aged ≥ 65 years without prior hip–pelvis or other non-vertebral fractures, identified in the German Pharmacoepidemiological Research Database (GePaRD) during 2005– 2014. Cases were patients first hospitalized for hip–pelvis or other non-vertebral fractures. Up to 100 controls per case were selected using incidence density sampling. AD use was ascertained at index date (ID) based on the supply of last dispensing. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using conditional logistic regression with current users of mirtazapine as reference (active comparator). RESULTS: A total of 39,853 cases of hip–pelvis fracture (80% women, median age 81 years) and 31,577 cases of other fractures (84% women, median age 79 years) were matched to > 3 million controls. For hip–pelvis fracture, aORs in current users were about 1.3 with little variation between individual ADs, ranging from 1.33 for citalopram (95% CI 1.27– 1.39) to 1.28 for amitriptyline (1.21– 1.35). For other fractures, the aORs were highest in current users of citalopram (1.50; 1.42– 1.58) and duloxetine (1.54; 1.39– 1.71) and lowest for amitriptyline (1.18; 1.11– 1.26) and trimipramine (1.16; 1.03– 1.29). For all examined ADs, the aORs were higher for other fractures than for hip–pelvis fracture. CONCLUSION: The risk of fractures varies between ADs, but for most agents is higher than the risk for mirtazapine. When treating older adults with ADs, prescribers should carefully consider the risk profile of individual ADs regarding fractures, which are a major health problem in this population.
1000 Sacherschließung
lokal Fractures
lokal Older adults
lokal Pharmacoepidemiology
lokal Health-care databases
lokal Hip fracture
lokal Pelvis fracture
lokal Antidepressants
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-0459-2616|https://orcid.org/0000-0001-8266-2574|https://frl.publisso.de/adhoc/uri/S29sbGhvcnN0LCBCaWFuY2E=|https://orcid.org/0000-0002-1886-2923|https://orcid.org/0000-0002-0224-1866
1000 Label
1000 Förderer
  1. Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) |
  2. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. Open Access Fund
1000 Dateien
  1. Individual Antidepressants and the Risk of Fractures in Older Adults: A New User Active Comparator Study
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6421830.rdf
1000 Erstellt am 2020-07-13T13:23:56.708+0200
1000 Erstellt von 266
1000 beschreibt frl:6421830
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet Tue Jul 14 07:32:28 CEST 2020
1000 Objekt bearb. Mon Jul 13 13:25:05 CEST 2020
1000 Vgl. frl:6421830
1000 Oai Id
  1. oai:frl.publisso.de:frl:6421830 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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