Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®

  1. Seidel, Danila ORCID logo
  2. Meißner, Arne
  3. Lackner, Michaela ORCID logo
  4. Piepenbrock, Ellen
  5. Salmanton-García, Jon ORCID logo
  6. Stecher, Melanie
  7. Mellinghoff, Sibylle ORCID logo
  8. Hamprecht, Axel ORCID logo
  9. Durán Graeff, Luisa ORCID logo
  10. Koehler, Philipp ORCID logo
  11. Cheng, Matthew P. ORCID logo
  12. Denis, Julie
  13. Chedotal, Isabelle
  14. Chander, Jagdish
  15. Pakstis, Diana Lynn
  16. Los-Arcos, Ibai ORCID logo
  17. Slavin, Monica ORCID logo
  18. Montagna, Maria Teresa ORCID logo
  19. Caggiano, Giuseppina ORCID logo
  20. Mares, Mihai ORCID logo
  21. Trauth, Janina
  22. Aurbach, Ute
  23. Vehreschild, Maria ORCID logo
  24. Vehreschild, Jörg ORCID logo
  25. Duarte, Rafael F.
  26. Herbrecht, Raoul ORCID logo
  27. Wisplinghoff, Hilmar
  28. Cornely, Oliver ORCID logo

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1000 Titel
  • Prognostic factors in 264 adults with invasive Scedosporium spp. and Lomentospora prolificans infection reported in the literature and FungiScope®
1000 Autor/in
  1. Seidel, Danila |
  2. Meißner, Arne |
  3. Lackner, Michaela |
  4. Piepenbrock, Ellen |
  5. Salmanton-García, Jon |
  6. Stecher, Melanie |
  7. Mellinghoff, Sibylle |
  8. Hamprecht, Axel |
  9. Durán Graeff, Luisa |
  10. Koehler, Philipp |
  11. Cheng, Matthew P. |
  12. Denis, Julie |
  13. Chedotal, Isabelle |
  14. Chander, Jagdish |
  15. Pakstis, Diana Lynn |
  16. Los-Arcos, Ibai |
  17. Slavin, Monica |
  18. Montagna, Maria Teresa |
  19. Caggiano, Giuseppina |
  20. Mares, Mihai |
  21. Trauth, Janina |
  22. Aurbach, Ute |
  23. Vehreschild, Maria |
  24. Vehreschild, Jörg |
  25. Duarte, Rafael F. |
  26. Herbrecht, Raoul |
  27. Wisplinghoff, Hilmar |
  28. Cornely, Oliver |
1000 Erscheinungsjahr 2019
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-01-10
1000 Erschienen in
1000 Quellenangabe
  • 45(1):1-21
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1080/1040841X.2018.1514366 |
1000 Ergänzendes Material
  • https://www.tandfonline.com/doi/suppl/10.1080/1040841X.2018.1514366?scroll=top |
1000 Interne Referenz
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • emerging threat in immunocompromised and occasionally in healthy hosts. Scedosporium spp. is intrinsically resistant to most, L. prolificans to all the antifungal drugs currently approved, raising concerns about appropriate treatment decisions. High mortality rates of up to 90% underline the need for comprehensive diagnostic workup and even more for new, effective antifungal drugs to improve patient outcome. For a comprehensive analysis, we identified cases of severe Scedosporium spp. and L. prolificans infections from the literature diagnosed in 2000 or later and the FungiScope® registry. For 208 Scedosporium spp. infections solid organ transplantation (n = 58, 27.9%) and for 56 L. prolificans infection underlying malignancy (n = 28, 50.0%) were the most prevalent risk factors. L. prolificans infections frequently presented as fungemia (n = 26, 46.4% versus n = 12, 5.8% for Scedosporium spp.). Malignancy, fungemia, CNS and lung involvement predicted worse outcome for scedosporiosis and lomentosporiosis. Patients treated with voriconazole had a better overall outcome in both groups compared to treatment with amphotericin B formulations. This review discusses the epidemiology, prognostic factors, pathogen susceptibility to approved and investigational antifungals, and treatment strategies of severe infections caused by Scedosporium spp. and L. prolificans.
1000 Sacherschließung
lokal antifungal treatment
lokal Scedosporiosis
lokal surgery
lokal invasive fungal disease
lokal lomentosporiosis
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4388-3117|https://frl.publisso.de/adhoc/uri/TWVpw59uZXIsIEFybmU=|https://orcid.org/0000-0001-9073-2886|https://frl.publisso.de/adhoc/uri/UGllcGVuYnJvY2ssIEVsbGVu|https://orcid.org/0000-0002-6766-8297|https://frl.publisso.de/adhoc/uri/U3RlY2hlciwgTWVsYW5pZQ==|https://orcid.org/0000-0003-3928-2503|https://orcid.org/0000-0003-1449-5780|https://orcid.org/0000-0001-5110-6356|https://orcid.org/0000-0002-7386-7495|https://orcid.org/0000-0002-4867-2063|https://frl.publisso.de/adhoc/uri/RGVuaXMsIEp1bGll|https://frl.publisso.de/adhoc/uri/Q2hlZG90YWwsIElzYWJlbGxl|https://frl.publisso.de/adhoc/uri/Q2hhbmRlciwgSmFnZGlzaA==|https://frl.publisso.de/adhoc/uri/UGFrc3RpcywgRGlhbmEgTHlubg==|https://orcid.org/0000-0001-8835-2702|https://orcid.org/0000-0002-8443-314X|https://orcid.org/0000-0002-2958-5458|https://orcid.org/0000-0003-3009-9147|https://orcid.org/0000-0002-3103-4954|https://frl.publisso.de/adhoc/uri/VHJhdXRoLCBKYW5pbmE=|https://frl.publisso.de/adhoc/uri/QXVyYmFjaCwgVXRl|https://orcid.org/0000-0002-7282-2842|https://orcid.org/0000-0002-5446-7170|https://frl.publisso.de/adhoc/uri/RHVhcnRlLCBSYWZhZWwgRi4=|https://orcid.org/0000-0002-9381-4876|https://frl.publisso.de/adhoc/uri/V2lzcGxpbmdob2ZmLCBIaWxtYXI=|https://orcid.org/0000-0001-9599-3137
1000 Hinweis
  • View correction statement: https://doi.org/10.1080/1040841X.2019.1574421
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1000 Erstellt am 2020-07-21T13:23:55.259+0200
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