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1000 Titel
  • Impacts of the synthetic androgen Trenbolone on gonad differentiation and development – comparisons between three deeply diverged anuran families
1000 Autor/in
  1. Rozenblut-Kościsty, Beata |
  2. Ogielska, Maria |
  3. Hahn, Juliane |
  4. Kleemann, Denise |
  5. Kossakowski, Ronja |
  6. Tamschick, Stephanie |
  7. Schöning, Viola |
  8. Krüger, Angela |
  9. Lutz, Ilka |
  10. Lymberakis, Petros |
  11. Kloas, Werner |
  12. Stöck, Matthias |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-07-03
1000 Erschienen in
1000 Quellenangabe
  • 9:9623
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41598-019-45985-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610071/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Using a recently developed approach for testing endocrine disruptive chemicals (EDCs) in amphibians, comprising synchronized tadpole exposure plus genetic and histological sexing of metamorphs in a flow-through-system, we tested the effects of 17β-Trenbolone (Tb), a widely used growth promoter in cattle farming, in three deeply diverged anuran families: the amphibian model species Xenopus laevis (Pipidae) and the non-models Bufo(tes) viridis (Bufonidae) and Hyla arborea (Hylidae). Trenbolone was applied in thhttps://www.tandfonline.com/doi/full/10.1080/22221751.2020.1760144?scroll=top&needAccess=trueree environmentally and/or physiologically relevant concentrations (0.027 µg/L (10−10 M), 0.27 µg/L (10−9 M), 2.7 µg/L (10−8 M)). In none of the species, Tb caused sex reversals or masculinization of gonads but had negative species-specific impacts on gonad morphology and differentiation after the completion of metamorphosis, independently of genetic sex. In H. arborea and B. viridis, mounting Tb-concentration correlated positively with anatomical abnormalities at 27 µg/L (10−9 M) and 2.7 µg/L (10−8 M), occurring in X. laevis only at the highest Tb concentration. Despite anatomical aberrations, histologically all gonadal tissues differentiated seemingly normally when examined at the histological level but at various rates. Tb-concentration caused various species-specific mortalities (low in Xenopus, uncertain in Bufo). Our data suggest that deep phylogenetic divergence modifies EDC-vulnerability, as previously demonstrated for Bisphenol A (BPA) and Ethinylestradiol (EE2).
1000 Sacherschließung
lokal Non-model organisms
lokal Agroecology
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Um96ZW5ibHV0LUtvxZtjaXN0eSwgQmVhdGEg|https://frl.publisso.de/adhoc/uri/T2dpZWxza2EsIE1hcmlh|https://frl.publisso.de/adhoc/uri/IEhhaG4sIEp1bGlhbmU=|https://frl.publisso.de/adhoc/uri/S2xlZW1hbm4sIERlbmlzZQ==|https://frl.publisso.de/adhoc/uri/S29zc2Frb3dza2ksIFJvbmph|https://frl.publisso.de/adhoc/uri/VGFtc2NoaWNrLCBTdGVwaGFuaWUgIA==|https://frl.publisso.de/adhoc/uri/U2Now7ZuaW5nLCBWaW9sYSA=|https://frl.publisso.de/adhoc/uri/S3LDvGdlciwgQW5nZWxh|https://frl.publisso.de/adhoc/uri/THV0eiwgSWxrYQ==|https://orcid.org/0000-0002-5067-9600|https://frl.publisso.de/adhoc/uri/S2xvYXMsIFdlcm5lcg==|https://orcid.org/0000-0003-4888-8371
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Hellenic Ministry of Environment and Energy |
  3. Leibniz-Gemeinschaft |
1000 Fördernummer
  1. Sto 493/3-1; Sto 493/2-2
  2. 115790/229
  3. -
1000 Förderprogramm
  1. HeisenbergFellowship
  2. -
  3. Open Access Fund
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm HeisenbergFellowship
    1000 Fördernummer Sto 493/3-1; Sto 493/2-2
  2. 1000 joinedFunding-child
    1000 Förderer Hellenic Ministry of Environment and Energy |
    1000 Förderprogramm -
    1000 Fördernummer 115790/229
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz-Gemeinschaft |
    1000 Förderprogramm Open Access Fund
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6423093.rdf
1000 Erstellt am 2020-09-23T09:07:59.047+0200
1000 Erstellt von 21
1000 beschreibt frl:6423093
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Wed Jun 02 07:38:29 CEST 2021
1000 Objekt bearb. Wed Jun 02 07:38:28 CEST 2021
1000 Vgl. frl:6423093
1000 Oai Id
  1. oai:frl.publisso.de:frl:6423093 |
1000 Sichtbarkeit Metadaten public
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