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Patterns of viral clearance in the natural course of asymptomatic COVID-19: Comparison with symptomatic non-severe COVID-19

  1. Uhm, Jae-Sun
  2. Ahn, Jin Young
  3. Hyun, JongHoon
  4. Sohn, Yujin
  5. Kim, Jung Ho
  6. Jeong, Su Jin
  7. Ku, Nam Su
  8. Choi, Jun Yong
  9. Park, Yu-Kyung
  10. Yi, Ho-sung
  11. Park, Sung Kyu
  12. Kim, Bong-Ok
  13. Kim, Hyewon
  14. Choi, Jinwoo
  15. Kang, Seung-mo
  16. Choi, Yeong Ho
  17. Yoon, Hae Kyoung
  18. Jung, Sunkyung
  19. Kim, Hyeong Nyeon
  20. Yeom, Joon-Sup
  21. Park, Yoon Soo

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WeightNameValue
1000 Titel
  • Patterns of viral clearance in the natural course of asymptomatic COVID-19: Comparison with symptomatic non-severe COVID-19
1000 Autor/in
  1. Uhm, Jae-Sun |
  2. Ahn, Jin Young |
  3. Hyun, JongHoon |
  4. Sohn, Yujin |
  5. Kim, Jung Ho |
  6. Jeong, Su Jin |
  7. Ku, Nam Su |
  8. Choi, Jun Yong |
  9. Park, Yu-Kyung |
  10. Yi, Ho-sung |
  11. Park, Sung Kyu |
  12. Kim, Bong-Ok |
  13. Kim, Hyewon |
  14. Choi, Jinwoo |
  15. Kang, Seung-mo |
  16. Choi, Yeong Ho |
  17. Yoon, Hae Kyoung |
  18. Jung, Sunkyung |
  19. Kim, Hyeong Nyeon |
  20. Yeom, Joon-Sup |
  21. Park, Yoon Soo |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-08-05
1000 Erschienen in
1000 Quellenangabe
  • 99:279-285
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.ijid.2020.07.070 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403105/ |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S1201971220306202#sec0085 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVES:The aim of this study was to elucidate patterns of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in the natural course of asymptomatic coronavirus disease 2019 (COVID-19). METHODS: Consecutive patients with non-severe COVID-19 were included retrospectively. Asymptomatic patients with a normal body temperature and no evidence of pneumonia throughout the disease course were assigned to the asymptomatic group. The reverse transcription PCR (RT-PCR) assay was repeated every two to five days after the first follow-up RT-PCR assay. Negative conversion was defined as two consecutive negative RT-PCR assay results within a 24-h interval. Rebound of the cycle threshold (Ct) value was defined as negative from the single RT-PCR assay and positive from the following assay. RESULTS: Among a total of 396 patients identified (median age 42.5 years (interquartile range (IQR) 25.0–55.0 years), 35.6% male), 68 (17.2%) were assigned to the asymptomatic group and 328 (82.8%) to the symptomatic group. The time until negative conversion was significantly shorter in the asymptomatic group than in the symptomatic group: median 14.5 days (IQR 11.0–21.0 days) and 18.0 days (IQR 15.0–22.0 days), respectively (p = 0.001). Rebound of Ct values was observed in 78 patients (19.7%). CONCLUSIONS: Time until negative conversion is shorter in asymptomatic COVID-19 than in symptomatic COVID-19. Rebound of Ct values is not uncommon.
1000 Sacherschließung
lokal Coronavirus disease 2019
gnd 1206347392 COVID-19
lokal Negative conversion
lokal Viral clearance
lokal SARS-CoV-2
lokal Asymptomatic
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Erstellt am 2020-11-23T08:27:01.505+0100
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1000 Zuletzt bearbeitet Fri Oct 01 17:11:38 CEST 2021
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