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1000 Titel
  • Effect of acute respiratory infections in infancy on pulmonary function test at 3 years of age: a prospective birth cohort study
1000 Autor/in
  1. Kumar, Prawin |
  2. Mukherjee, Aparna |
  3. Randev, Shivani |
  4. Medigeshi, Guruprasad R |
  5. Jat, Kana Ram |
  6. Kapil, Arti |
  7. Lodha, Rakesh |
  8. Kabra, Sushil |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-02-19
1000 Erschienen in
1000 Quellenangabe
  • 7(1):e000436
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1136/bmjresp-2019-000436 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047475/ |
1000 Ergänzendes Material
  • https://bmjopenrespres.bmj.com/content/7/1/e000436#DC1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: Acute respiratory infections (ARIs) in infancy may have a long-term impact on the developing respiratory system. We planned a prospective cohort study to determine the impact of ARI during infancy on the pulmonary function test indices at 3 years of age. METHODS: A cohort of normal, full-term newborns were followed up 6 monthly and during ARI episodes. Infant pulmonary function tests (IPFTs) were performed at baseline and each follow-up visit using tidal breathing flow-volume loop, rapid thoracoabdominal compression (RTC) and raised volume RTC manoeuvres. During each ARI episode, nasopharyngeal aspirates were tested for respiratory pathogens by real-time PCR. RESULTS: We screened 3421 neonates; 310 were enrolled; IPFT was performed in 225 (boys: 125 (55.6%)) at 3 years. During infancy, 470 ARI episodes were documented in 173 infants. At 3 years, children with history of any ARI episode during infancy had lower forced expiratory volume in 1 s (FEV1.0), forced expiratory volume in 0.75 s (FEV0.75), forced expiratory volume in 0.5 s (FEV0.5), forced expiratory flow between 25% and 75% of FVC (FEF25–75), and maximal expiratory flow at 25% of FVC (MEF25) as compared with those without any ARI episode during infancy. The ratio of tidal expiratory flow (TEF) at 25% or 50% of tidal expiratory volume to peak TEF (TEF50 or TEF25/peak TEF) at 3 years was significantly increased in children who had ARI in infancy. CONCLUSIONS: ARI during infancy is associated with impaired pulmonary function indices such as increased resistance and decreased forced expiratory flow and volume at 3 years of age.
1000 Sacherschließung
lokal viruses
lokal infant
lokal rhinovirus
lokal tidal volume
lokal indices
lokal acute respiratory tract infection
lokal forced expiratory volume
lokal pulmonary function test
lokal respiratory syncytial virus
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S3VtYXIsIFByYXdpbg==|https://frl.publisso.de/adhoc/uri/TXVraGVyamVlLCBBcGFybmE=|https://frl.publisso.de/adhoc/uri/UmFuZGV2LCBTaGl2YW5p|https://frl.publisso.de/adhoc/uri/TWVkaWdlc2hpLCBHdXJ1cHJhc2FkIFI=|https://orcid.org/0000-0003-3642-246X|https://frl.publisso.de/adhoc/uri/S2FwaWwsIEFydGk=|https://frl.publisso.de/adhoc/uri/TG9kaGEsIFJha2VzaA==|https://orcid.org/0000-0003-2616-9157
1000 Label
1000 Förderer
  1. Department of Biotechnology, Ministry of Science and Technology, India |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Department of Biotechnology, Ministry of Science and Technology, India |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6424966.rdf
1000 Erstellt am 2020-12-22T11:32:57.091+0100
1000 Erstellt von 5
1000 beschreibt frl:6424966
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Feb 11 07:30:15 CET 2021
1000 Objekt bearb. Thu Feb 11 07:30:01 CET 2021
1000 Vgl. frl:6424966
1000 Oai Id
  1. oai:frl.publisso.de:frl:6424966 |
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