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1000 Titel
  • Observational study of azithromycin in hospitalized patients with COVID-19
1000 Autor/in
  1. Rodríguez-Molinero, Alejandro |
  2. Pérez-López, Carlos |
  3. Gálvez-Barrón, César |
  4. Miñarro, Antonio |
  5. Macho, Oscar |
  6. López, Gabriela F. |
  7. Robles, Maria Teresa |
  8. Dapena, María Dolores |
  9. Martínez, Sergi |
  10. Rodríguez, Ezequiel |
  11. Collado, Isabel |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-03
1000 Erschienen in
1000 Quellenangabe
  • 15(9):e0238681
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0238681 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470304/ |
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1000 Abstract/Summary
  • BACKGROUND: The rapid spread of the disease caused by the novel SARS-CoV-2 virus has led to the use of multiple therapeutic agents whose efficacy has not been previously demonstrated. The objective of this study was to analyze whether there is an association between the use of azithromycin and the evolution of the pulmonary disease or the time to discharge, in patients hospitalized with COVID-19. METHODS: This was an observational study on a cohort of 418 patients admitted to three regional hospitals in Catalonia, Spain. As primary outcomes, we studied the evolution of SAFI ratio (oxygen saturation/fraction of inspired oxygen) in the first 48 hours of treatment and the time to discharge. The results were compared between patients treated and untreated with the study drug through subcohort analyses matched for multiple clinical and prognostic factors, as well as through analysis of non-matched subcohorts, using Cox multivariate models adjusted for prognostic factors. RESULTS: There were 239 patients treated with azithromycin. Of these, 29 patients treated with azithromycin could be matched with an equivalent number of control patients. In the analysis of these matched subcohorts, SAFI at 48h had no significant changes associated to the use of azithromycin, though azithromycin treatment was associated with a longer time to discharge (10.0 days vs 6.7 days; log rank: p = 0.039). However, in the unmatched cohorts, the increased hospital stay associated to azithromycin use, was no significant after adjustment using Multivariate Cox regression models: hazard ratio 1.45 (IC95%: 0.88–2.41; p = 0.150). This study is limited by its small sample size and its observational nature; despite the strong pairing of the matched subcohorts and the adjustment of the Cox regression for multiple factors, the results may be affected by residual confusion. CONCLUSIONS: We did not find a clinical benefit associated with the use of azithromycin, in terms of lung function 48 hours after treatment or length of hospital stay.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal C-reactive proteins
lokal Hospitals
lokal Corticosteroid therapy
lokal Observational studies
lokal SARS CoV 2
lokal Drug therapy
lokal Oxygen
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  1. https://orcid.org/0000-0002-9678-2654|https://frl.publisso.de/adhoc/uri/UMOpcmV6LUzDs3BleiwgQ2FybG9z|https://frl.publisso.de/adhoc/uri/R8OhbHZlei1CYXJyw7NuLCBDw6lzYXI=|https://frl.publisso.de/adhoc/uri/TWnDsWFycm8sIEFudG9uaW8=|https://frl.publisso.de/adhoc/uri/TWFjaG8sIE9zY2Fy|https://frl.publisso.de/adhoc/uri/TMOzcGV6LCBHYWJyaWVsYSBGLg==|https://frl.publisso.de/adhoc/uri/Um9ibGVzLCBNYXJpYSBUZXJlc2Eg|https://frl.publisso.de/adhoc/uri/RGFwZW5hLCBNYXLDrWEgRG9sb3Jlcw==|https://frl.publisso.de/adhoc/uri/TWFydMOtbmV6LCBTZXJnaSA=|https://frl.publisso.de/adhoc/uri/Um9kcsOtZ3VleiwgRXplcXVpZWw=|https://frl.publisso.de/adhoc/uri/IENvbGxhZG8sIElzYWJlbA==
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1000 Erstellt am 2021-04-08T11:23:59.440+0200
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1000 Zuletzt bearbeitet Wed May 05 10:35:49 CEST 2021
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