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1000 Titel
  • The impact of individual electrical fields and anatomical factors on the neurophysiological outcomes of tDCS: A TMS-MEP and MRI study
1000 Autor/in
  1. mosayebi samani, mohsen |
  2. Jamil, Asif |
  3. Salvador, Ricardo |
  4. Ruffini, Gulio |
  5. Haueisen, Jens |
  6. Nitsche, Michael |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-28
1000 Erschienen in
1000 Quellenangabe
  • 14(2):316-326
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.brs.2021.01.016 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S1935861X21000218#appsec1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Transcranial direct current stimulation (tDCS), a neuromodulatory non-invasive brain stimulation technique, has shown promising results in basic and clinical studies. The known interindividual variability of the effects, however, limits the efficacy of the technique. Recently we reported neurophysiological effects of tDCS applied over the primary motor cortex at the group level, based on data from twenty-nine participants who received 15min of either sham, 0.5, 1.0, 1.5 or 2.0 mA anodal, or cathodal tDCS. The neurophysiological effects were evaluated via changes in: 1) transcranial magnetic stimulation (TMS)-induced motor evoked potentials (MEP), and 2) cerebral blood flow (CBF) measured by functional magnetic resonance imaging (MRI) via arterial spin labeling (ASL). At the group level, dose-dependent effects of the intervention were obtained, which however displayed interindividual variability. METHOD: In the present study, we investigated the cause of the observed inter-individual variability. To this end, for each participant, a MRI-based realistic head model was designed to 1) calculate anatomical factors and 2) simulate the tDCS- and TMS-induced electrical fields (EFs). We first investigated at the regional level which individual anatomical factors explained the simulated EFs (magnitude and normal component). Then, we explored which specific anatomical and/or EF factors predicted the neurophysiological outcomes of tDCS. RESULTS: The results highlight a significant negative correlation between regional electrode-to-cortex distance (rECD) as well as regional CSF (rCSF) thickness, and the individual EF characteristics. In addition, while both rCSF thickness and rECD anticorrelated with tDCS-induced physiological changes, EFs positively correlated with the effects. CONCLUSION: These results provide novel insights into the dependency of the neuromodulatory effects of tDCS on individual physical factors.
1000 Sacherschließung
lokal TMS
lokal Computational neurostimulation
lokal Inter-individual variability
lokal MEP
lokal FEM
lokal fMRI
lokal tDCS
lokal CBF
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-3826-5795|https://orcid.org/0000-0003-3497-675X|https://frl.publisso.de/adhoc/uri/U2FsdmFkb3IsIFJpY2FyZG8=|https://frl.publisso.de/adhoc/uri/UnVmZmluaSwgR3VsaW8=|https://frl.publisso.de/adhoc/uri/SGF1ZWlzZW4sIEplbnM=|https://orcid.org/0000-0002-2207-5965
1000 Label
1000 Förderer
  1. Bundesministerium für Bildung und Forschung |
1000 Fördernummer
  1. 01EE1501; 01GQ1424E
1000 Förderprogramm
  1. GCBS; TRAINSTIM
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm GCBS; TRAINSTIM
    1000 Fördernummer 01EE1501; 01GQ1424E
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427267.rdf
1000 Erstellt am 2021-05-05T13:23:55.678+0200
1000 Erstellt von 254
1000 beschreibt frl:6427267
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu May 06 08:13:32 CEST 2021
1000 Objekt bearb. Thu May 06 08:13:14 CEST 2021
1000 Vgl. frl:6427267
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427267 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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