Download
Sallard2021_Article_TracingTheOriginsOfSARS-COV-2I.pdf 6,42MB
WeightNameValue
1000 Titel
  • Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review
1000 Autor/in
  1. Sallard, Erwan |
  2. Halloy, José |
  3. Casane, Didier |
  4. DECROLY, Etienne |
  5. van Helden, Jacques |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-04
1000 Erschienen in
1000 Quellenangabe
  • 19(2):769-785
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s10311-020-01151-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859469 |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007%2Fs10311-020-01151-1#Sec18 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • SARS-CoV-2 is a new human coronavirus (CoV), which emerged in China in late 2019 and is responsible for the global COVID-19 pandemic that caused more than 97 million infections and 2 million deaths in 12 months. Understanding the origin of this virus is an important issue, and it is necessary to determine the mechanisms of viral dissemination in order to contain future epidemics. Based on phylogenetic inferences, sequence analysis and structure–function relationships of coronavirus proteins, informed by the knowledge currently available on the virus, we discuss the different scenarios on the origin—natural or synthetic—of the virus. The data currently available are not sufficient to firmly assert whether SARS-CoV2 results from a zoonotic emergence or from an accidental escape of a laboratory strain. This question needs to be solved because it has important consequences on the risk/benefit balance of our interactions with ecosystems, on intensive breeding of wild and domestic animals, on some laboratory practices and on scientific policy and biosafety regulations. Regardless of COVID-19 origin, studying the evolution of the molecular mechanisms involved in the emergence of pandemic viruses is essential to develop therapeutic and vaccine strategies and to prevent future zoonoses. This article is a translation and update of a French article published in Médecine/Sciences, August/September 2020 (https://doi.org/10.1051/medsci/2020123).
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Biosafety
lokal Zoonosis
lokal Gain of function
lokal Virology
lokal Bioinformatics
lokal Phylogeny
lokal Spike protein
lokal Coronavirus
lokal Furin
lokal Pandemic
lokal Genome analysis
lokal SARS-CoV-2
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0002-2324-3633|https://orcid.org/0000-0003-1555-2484|https://orcid.org/0000-0001-5463-1092|https://orcid.org/0000-0002-6046-024X|https://orcid.org/0000-0002-8799-8584
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427421.rdf
1000 Erstellt am 2021-05-12T09:54:59.154+0200
1000 Erstellt von 218
1000 beschreibt frl:6427421
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Wed Aug 04 07:41:16 CEST 2021
1000 Objekt bearb. Wed Aug 04 07:41:03 CEST 2021
1000 Vgl. frl:6427421
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427421 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source