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1000 Titel
  • Impact of dietary sulfolipid-derived sulfoquinovose on gut microbiota composition and inflammatory status of colitis-prone interleukin-10-deficient mice
1000 Autor/in
  1. Burkhardt, Wiebke |
  2. Rausch, Theresa |
  3. Klopfleisch, Robert |
  4. Blaut, Michael |
  5. Braune, Annett |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-25
1000 Erschienen in
1000 Quellenangabe
  • 311(3):151494
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.ijmm.2021.151494 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S1438422121000230?via%3Dihub#sec0110 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The interplay between diet, intestinal microbiota and host is a major factor impacting health. A diet rich in unsaturated fatty acids has been reported to stimulate the growth of Bilophila wadsworthia by increasing the proportion of the sulfonated bile acid taurocholate (TC). The taurine-induced overgrowth of B. wadsworthia promoted the development of colitis in interleukin-10-deficient (IL-10-/-) mice. This study aimed to investigate whether intake of the sulfonates sulfoquinovosyl diacylglycerols (SQDG) with a dietary supplement or their degradation product sulfoquinovose (SQ), stimulate the growth of B. wadsworthia in a similar manner and, thereby, cause intestinal inflammation. Conventional IL-10-/- mice were fed a diet supplemented with the SQDG-rich cyanobacterium Arthrospira platensis (Spirulina). SQ or TC were orally applied to conventional IL-10-/- mice and gnotobiotic IL-10-/- mice harboring a simplified human intestinal microbiota with or without B. wadsworthia. Analyses of inflammatory parameters revealed that none of the sulfonates induced severe colitis, but both, Spirulina and TC, induced expression of pro-inflammatory cytokines in cecal mucosa. Cell numbers of B. wadsworthia decreased almost two orders of magnitude by Spirulina feeding but slightly increased in gnotobiotic SQ and conventional TC mice. Changes in microbiota composition were observed in feces as a result of Spirulina or TC feeding in conventional mice. In conclusion, the dietary sulfonates SQDG and their metabolite SQ did not elicit bacteria-induced intestinal inflammation in IL-10-/- mice and, thus, do not promote colitis.
1000 Sacherschließung
lokal Sulfonate
lokal Spirulina
lokal Taurocholate
lokal Inflammatory bowel disease
lokal Sulfoquinovose
lokal Bilophila wadsworthia
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/QnVya2hhcmR0LCBXaWVia2U=|https://frl.publisso.de/adhoc/uri/UmF1c2NoLCBUaGVyZXNh|https://frl.publisso.de/adhoc/uri/S2xvcGZsZWlzY2gsIFJvYmVydA==|https://frl.publisso.de/adhoc/uri/QmxhdXQsIE1pY2hhZWw=|https://frl.publisso.de/adhoc/uri/QnJhdW5lLCBBbm5ldHQ=
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. BR 2269/5-1; BL 257/13-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer BR 2269/5-1; BL 257/13-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427667.rdf
1000 Erstellt am 2021-05-25T11:20:36.594+0200
1000 Erstellt von 25
1000 beschreibt frl:6427667
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue May 25 11:22:52 CEST 2021
1000 Objekt bearb. Tue May 25 11:22:20 CEST 2021
1000 Vgl. frl:6427667
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427667 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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