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1000 Titel
  • Effects of Insoluble Cereal Fibre on Body Fat Distribution in the Optimal Fibre Trial
1000 Autor/in
  1. Kabisch, Stefan |
  2. Honsek, Caroline |
  3. Kemper, Margrit |
  4. Gerbracht, Christiana |
  5. Meyer, Nina Marie Tosca |
  6. Arafat, Ayman M. |
  7. Birkenfeld, Andreas L. |
  8. Machann, Jürgen |
  9. Dambeck, Ulrike |
  10. Osterhoff, Martin A. |
  11. Weickert, Martin O. |
  12. Pfeiffer, Andreas F. H. |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-04-28
1000 Erschienen in
1000 Quellenangabe
  • Early View (2000991)
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1002/mnfr.202000991 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • SCOPE: The Optimal Fibre Trial (OptiFiT) investigates metabolic effects of insoluble cereal fibre in subjects with impaired glucose tolerance (IGT), showing moderate glycemic and anti-inflammatory benefits, especially in subjects with an obesity-related phenotype. An OptiFiT sub-group is analysed for effects on body fat distribution. METHODS AND RESULTS: 180 participants with IGT receive a blinded, randomized supplementation with insoluble cereal fibre or placebo for 2 years. Once a year, all subjects undergo fasting blood sampling, oral glucose tolerance test, and anthropometric measurements. A subgroup (n=47) also received magnetic resonance imaging and spectroscopy for quantification of adipose tissue distribution and liver fat content. We compared MR, metabolic and inflammatory outcomes between fibre and placebo group metabolism and inflammation. Visceral and non-visceral fat, fasting glucose, HbA1c, fasting insulin, insulin resistance, and uric acid decrease only in the fibre group, mirroring effects of the entire cohort. However, after adjustment for weight loss, there are no significant between-group differences. There is a statistical trend for fibre-driven liver fat reduction in subjects with confirmed non-alcoholic fatty liver disease (NAFLD; n = 19). CONCLUSIONS: Data and evidence on beneficial effects of insoluble cereal fibre on visceral and hepatic fatstorage is limited, but warrants further research. Targeted trials are required.
1000 Sacherschließung
lokal diabetes prevention
lokal impaired glucose tolerance
lokal diabetes mellitus type 2
lokal liver fat
lokal prediabetes
lokal insoluble dietary fibre
lokal visceral adipose tissue
lokal non-alcoholic fatty liver disease
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/S2FiaXNjaCwgU3RlZmFu|https://frl.publisso.de/adhoc/uri/SG9uc2VrLCBDYXJvbGluZQ==|https://frl.publisso.de/adhoc/uri/S2VtcGVyLCBNYXJncml0|https://frl.publisso.de/adhoc/uri/R2VyYnJhY2h0LCBDaHJpc3RpYW5h|https://frl.publisso.de/adhoc/uri/TWV5ZXIsIE5pbmEgTWFyaWUgVG9zY2E=|https://frl.publisso.de/adhoc/uri/QXJhZmF0LCBBeW1hbiBNLg==|https://frl.publisso.de/adhoc/uri/Qmlya2VuZmVsZCwgQW5kcmVhcyBMLg==|https://frl.publisso.de/adhoc/uri/TWFjaGFubiwgSsO8cmdlbg==|https://frl.publisso.de/adhoc/uri/RGFtYmVjaywgVWxyaWtl|https://frl.publisso.de/adhoc/uri/T3N0ZXJob2ZmLCBNYXJ0aW4gQS4=|https://frl.publisso.de/adhoc/uri/V2VpY2tlcnQsIE1hcnRpbiBPLg==|https://frl.publisso.de/adhoc/uri/UGZlaWZmZXIsIEFuZHJlYXMgRi4gSC4=
1000 Label
1000 Förderer
  1. Diabetes-Stiftung |
1000 Fördernummer
  1. 232/11/08
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Diabetes-Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer 232/11/08
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427683.rdf
1000 Erstellt am 2021-05-25T12:46:00.700+0200
1000 Erstellt von 25
1000 beschreibt frl:6427683
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue May 25 12:47:26 CEST 2021
1000 Objekt bearb. Tue May 25 12:46:46 CEST 2021
1000 Vgl. frl:6427683
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427683 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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