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1000 Titel
  • Regulation of diurnal energy balance by mitokines
1000 Autor/in
  1. Klaus, Susanne |
  2. Igual Gil, Carla |
  3. Ost, Mario |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-19
1000 Erschienen in
1000 Quellenangabe
  • 78(7):3369-3384
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00018-020-03748-9 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814174/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The mammalian system of energy balance regulation is intrinsically rhythmic with diurnal oscillations of behavioral and metabolic traits according to the 24 h day/night cycle, driven by cellular circadian clocks and synchronized by environmental or internal cues such as metabolites and hormones associated with feeding rhythms. Mitochondria are crucial organelles for cellular energy generation and their biology is largely under the control of the circadian system. Whether mitochondrial status might also feed-back on the circadian system, possibly via mitokines that are induced by mitochondrial stress as endocrine-acting molecules, remains poorly understood. Here, we describe our current understanding of the diurnal regulation of systemic energy balance, with focus on fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15), two well-known endocrine-acting metabolic mediators. FGF21 shows a diurnal oscillation and directly affects the output of the brain master clock. Moreover, recent data demonstrated that mitochondrial stress-induced GDF15 promotes a day-time restricted anorexia and systemic metabolic remodeling as shown in UCP1-transgenic mice, where both FGF21 and GDF15 are induced as myomitokines. In this mouse model of slightly uncoupled skeletal muscle mitochondria GDF15 proved responsible for an increased metabolic flexibility and a number of beneficial metabolic adaptations. However, the molecular mechanisms underlying energy balance regulation by mitokines are just starting to emerge, and more data on diurnal patterns in mouse and man are required. This will open new perspectives into the diurnal nature of mitokines and action both in health and disease.
1000 Sacherschließung
lokal Hormones
lokal Mitochondria
lokal Nutrition
lokal GDF15
lokal Circadian rhythm
lokal FGF21
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-8726-185X|https://frl.publisso.de/adhoc/uri/SWd1YWwgR2lsLCBDYXJsYQ==|https://frl.publisso.de/adhoc/uri/T3N0LCBNYXJpbw==
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Regulation of diurnal energy balance by mitokines
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6427730.rdf
1000 Erstellt am 2021-05-27T09:48:42.059+0200
1000 Erstellt von 25
1000 beschreibt frl:6427730
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu May 27 09:49:53 CEST 2021
1000 Objekt bearb. Thu May 27 09:49:28 CEST 2021
1000 Vgl. frl:6427730
1000 Oai Id
  1. oai:frl.publisso.de:frl:6427730 |
1000 Sichtbarkeit Metadaten public
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