Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples

  1. Chen, Chu
  2. Lohavanichbutr, Pawadee
  3. Zhang, Yuzheng
  4. Houck, John R.
  5. Upton, Melissa P.
  6. Abedi-Ardekani, Behnoush
  7. Agudo, Antonio
  8. Ahrens, Wolfgang ORCID logo
  9. Alemany, Laia
  10. Anantharaman, Devasena
  11. Conway, David I.
  12. Futran, Neal D.
  13. Holcátová, Ivana
  14. Günther, Kathrin ORCID logo
  15. Hansen, Bo T.
  16. Healy, Claire M.
  17. Itani, Doha
  18. Kjaerheim, Kristina
  19. Monroe, Marcus M.
  20. Thomson, Peter J.
  21. Witt, Benjamin L.
  22. Nakoneshny, Steven
  23. Peterson, Lisa A.
  24. Schwartz, Stephen M.
  25. Zarins, Katie R.
  26. Hashibe, Mia
  27. Brennan, Paul
  28. Rozek, Laura S.
  29. Wolf, Gregory
  30. Dort, Joseph C.
  31. Wang, Pei

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1000 Titel
  • Prediction of survival of HPV16-negative, p16-negative oral cavity cancer patients using a 13-gene signature: A multicenter study using FFPE samples
1000 Autor/in
  1. Chen, Chu |
  2. Lohavanichbutr, Pawadee |
  3. Zhang, Yuzheng |
  4. Houck, John R. |
  5. Upton, Melissa P. |
  6. Abedi-Ardekani, Behnoush |
  7. Agudo, Antonio |
  8. Ahrens, Wolfgang |
  9. Alemany, Laia |
  10. Anantharaman, Devasena |
  11. Conway, David I. |
  12. Futran, Neal D. |
  13. Holcátová, Ivana |
  14. Günther, Kathrin |
  15. Hansen, Bo T. |
  16. Healy, Claire M. |
  17. Itani, Doha |
  18. Kjaerheim, Kristina |
  19. Monroe, Marcus M. |
  20. Thomson, Peter J. |
  21. Witt, Benjamin L. |
  22. Nakoneshny, Steven |
  23. Peterson, Lisa A. |
  24. Schwartz, Stephen M. |
  25. Zarins, Katie R. |
  26. Hashibe, Mia |
  27. Brennan, Paul |
  28. Rozek, Laura S. |
  29. Wolf, Gregory |
  30. Dort, Joseph C. |
  31. Wang, Pei |
1000 Erscheinungsjahr 2019
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2019-12-10
1000 Erschienen in
1000 Quellenangabe
  • 100:104487
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2019
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.oraloncology.2019.104487 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386199/ |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S1368837519303987?via%3Dihub#s0075 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVES: To test the performance of an oral cancer prognostic 13-gene signature for the prediction of survival of patients diagnosed with HPV-negative and p16-negative oral cavity cancer. MATERIALS AND METHODS: Diagnostic formalin-fixed paraffin-embedded oral cavity cancer tumor samples were obtained from the Fred Hutchinson Cancer Research Center/University of Washington, University of Calgary, University of Michigan, University of Utah, and seven ARCAGE study centers coordinated by the International Agency of Research on Cancer. RNA from 638 Human Papillomavirus (HPV)-negative and p16-negative samples was analyzed for the 13 genes using a NanoString assay. Ridge-penalized Cox regressions were applied to samples randomly split into discovery and validation sets to build models and evaluate the performance of the 13-gene signature in predicting 2-year oral cavity cancer-specific survival overall and separately for patients with early and late stage disease. RESULTS: Among AJCC stage I/II patients, including the 13-gene signature in the model resulted in substantial improvement in the prediction of 2-year oral cavity cancer-specific survival. For models containing age and sex with and without the 13-gene signature score, the areas under the Receiver Operating Characteristic Curve (AUC) and partial AUC were 0.700 vs. 0.537 (p < 0.001), and 0.046 vs. 0.018 (p < 0.001), respectively. Improvement in predicting prognosis for AJCC stage III/IV disease also was observed, but to a lesser extent. CONCLUSION: If confirmed using tumor samples from a larger number of early stage oral cavity cancer patients, the 13-gene signature may inform personalized treatment of early stage HPV-negative and p16-negative oral cavity cancer patients.
1000 Sacherschließung
lokal P16
lokal Prognostic gene signature
lokal HPV
lokal Oral cancer
lokal Prognosis
lokal Oral cavity cancer
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/Q2hlbiwgQ2h1|https://frl.publisso.de/adhoc/uri/TG9oYXZhbmljaGJ1dHIsIFBhd2FkZWU=|https://frl.publisso.de/adhoc/uri/WmhhbmcsIFl1emhlbmc=|https://frl.publisso.de/adhoc/uri/SG91Y2ssIEpvaG4gUi4=|https://frl.publisso.de/adhoc/uri/VXB0b24sIE1lbGlzc2EgUC4=|https://frl.publisso.de/adhoc/uri/QWJlZGktQXJkZWthbmksIEJlaG5vdXNo|https://frl.publisso.de/adhoc/uri/QWd1ZG8sIEFudG9uaW8=|https://orcid.org/0000-0003-3777-570X|https://frl.publisso.de/adhoc/uri/QWxlbWFueSwgTGFpYQ==|https://frl.publisso.de/adhoc/uri/QW5hbnRoYXJhbWFuLCBEZXZhc2VuYQ==|https://frl.publisso.de/adhoc/uri/Q29ud2F5LCBEYXZpZCBJLg==|https://frl.publisso.de/adhoc/uri/RnV0cmFuLCBOZWFsIEQu|https://frl.publisso.de/adhoc/uri/SG9sY8OhdG92w6EsIEl2YW5h|https://orcid.org/0000-0001-6347-7154|https://frl.publisso.de/adhoc/uri/SGFuc2VuLCBCbyBULg==|https://frl.publisso.de/adhoc/uri/SGVhbHksIENsYWlyZSBNLg==|https://frl.publisso.de/adhoc/uri/SXRhbmksIERvaGE=|https://frl.publisso.de/adhoc/uri/S2phZXJoZWltLCBLcmlzdGluYQ==|https://frl.publisso.de/adhoc/uri/TW9ucm9lLCBNYXJjdXMgTS4=|https://frl.publisso.de/adhoc/uri/VGhvbXNvbiwgUGV0ZXIgSi4=|https://frl.publisso.de/adhoc/uri/V2l0dCwgQmVuamFtaW4gTC4=|https://frl.publisso.de/adhoc/uri/TmFrb25lc2hueSwgU3RldmVu|https://frl.publisso.de/adhoc/uri/UGV0ZXJzb24sIExpc2EgQS4=|https://frl.publisso.de/adhoc/uri/U2Nod2FydHosIFN0ZXBoZW4gTS4=|https://frl.publisso.de/adhoc/uri/WmFyaW5zLCBLYXRpZSBSLg==|https://frl.publisso.de/adhoc/uri/SGFzaGliZSwgTWlh|https://frl.publisso.de/adhoc/uri/QnJlbm5hbiwgUGF1bA==|https://frl.publisso.de/adhoc/uri/Um96ZWssIExhdXJhIFMu|https://frl.publisso.de/adhoc/uri/V29sZiwgR3JlZ29yeQ==|https://frl.publisso.de/adhoc/uri/RG9ydCwgSm9zZXBoIEMu|https://frl.publisso.de/adhoc/uri/V2FuZywgUGVp
1000 Label
1000 Förderer
  1. National Cancer Institute |
  2. Fred Hutchinson Cancer Research Center |
  3. University of Washington |
  4. National Institutes of Health |
  5. National Institute on Deafness and Other Communication Disorders |
1000 Fördernummer
  1. 1 R01 CA177736-01A1; P30CA015704
  2. P30CA015704
  3. P30CA015704
  4. U24 CA210993; R01CA095419; K12RR023265
  5. T32DC00018
1000 Förderprogramm
  1. -
  2. Genomics Shared Resource of the Cancer Consortium
  3. Genomics Shared Resource of the Cancer Consortium
  4. Career Development Programs for Clinical Researchers
  5. National Research Service Award
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Cancer Institute |
    1000 Förderprogramm -
    1000 Fördernummer 1 R01 CA177736-01A1; P30CA015704
  2. 1000 joinedFunding-child
    1000 Förderer Fred Hutchinson Cancer Research Center |
    1000 Förderprogramm Genomics Shared Resource of the Cancer Consortium
    1000 Fördernummer P30CA015704
  3. 1000 joinedFunding-child
    1000 Förderer University of Washington |
    1000 Förderprogramm Genomics Shared Resource of the Cancer Consortium
    1000 Fördernummer P30CA015704
  4. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm Career Development Programs for Clinical Researchers
    1000 Fördernummer U24 CA210993; R01CA095419; K12RR023265
  5. 1000 joinedFunding-child
    1000 Förderer National Institute on Deafness and Other Communication Disorders |
    1000 Förderprogramm National Research Service Award
    1000 Fördernummer T32DC00018
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6428595.rdf
1000 Erstellt am 2021-07-23T12:23:03.138+0200
1000 Erstellt von 266
1000 beschreibt frl:6428595
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2021-07-28T11:36:48.025+0200
1000 Objekt bearb. Wed Jul 28 11:36:37 CEST 2021
1000 Vgl. frl:6428595
1000 Oai Id
  1. oai:frl.publisso.de:frl:6428595 |
1000 Sichtbarkeit Metadaten public
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