An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

  1. Zaer, Hamed
  2. Deshmukh, Ashlesha
  3. Orlowski, Dariusz
  4. Fan, Wei
  5. Prouvot, Pierre-Hugues
  6. Glud, Andreas Nørgaard
  7. Jensen, Morten Bjørn
  8. Worm, Esben Schjødt
  9. Lukacova, Slávka
  10. Mikkelsen, Trine Werenberg
  11. Fitting, Lise Moberg
  12. Adler, John R.
  13. Schneider, M. Bret
  14. Jensen, Martin Snejbjerg
  15. Fu, Quanhai
  16. Go, Vinson
  17. Morizio, James
  18. Sørensen, Jens Christian Hedemann
  19. Stroh, Albrecht

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1000 Titel
  • An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention
1000 Autor/in
  1. Zaer, Hamed |
  2. Deshmukh, Ashlesha |
  3. Orlowski, Dariusz |
  4. Fan, Wei |
  5. Prouvot, Pierre-Hugues |
  6. Glud, Andreas Nørgaard |
  7. Jensen, Morten Bjørn |
  8. Worm, Esben Schjødt |
  9. Lukacova, Slávka |
  10. Mikkelsen, Trine Werenberg |
  11. Fitting, Lise Moberg |
  12. Adler, John R. |
  13. Schneider, M. Bret |
  14. Jensen, Martin Snejbjerg |
  15. Fu, Quanhai |
  16. Go, Vinson |
  17. Morizio, James |
  18. Sørensen, Jens Christian Hedemann |
  19. Stroh, Albrecht |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-02-03
1000 Erschienen in
1000 Quellenangabe
  • 15:618626
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fnhum.2021.618626 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7887289 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.
1000 Sacherschließung
lokal electrophysiology
lokal Göttingen minipig
lokal neuromodulation
lokal brain-machine (computer) interface
lokal animal model
lokal EEG
lokal stereotactic radiosurgery
lokal closed-loop
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/WmFlciwgSGFtZWQ=|https://frl.publisso.de/adhoc/uri/RGVzaG11a2gsIEFzaGxlc2hh|https://frl.publisso.de/adhoc/uri/T3Jsb3dza2ksIERhcml1c3o=|https://frl.publisso.de/adhoc/uri/RmFuLCBXZWk=|https://frl.publisso.de/adhoc/uri/UHJvdXZvdCwgUGllcnJlLUh1Z3Vlcw==|https://frl.publisso.de/adhoc/uri/R2x1ZCwgQW5kcmVhcyBOw7hyZ2FhcmQ=|https://frl.publisso.de/adhoc/uri/SmVuc2VuLCBNb3J0ZW4gQmrDuHJu|https://frl.publisso.de/adhoc/uri/V29ybSwgRXNiZW4gU2NoasO4ZHQ=|https://frl.publisso.de/adhoc/uri/THVrYWNvdmEsIFNsw6F2a2E=|https://frl.publisso.de/adhoc/uri/TWlra2Vsc2VuLCBUcmluZSBXZXJlbmJlcmc=|https://frl.publisso.de/adhoc/uri/Rml0dGluZywgTGlzZSBNb2Jlcmc=|https://frl.publisso.de/adhoc/uri/QWRsZXIsIEpvaG4gUi4=|https://frl.publisso.de/adhoc/uri/U2NobmVpZGVyLCBNLiBCcmV0|https://frl.publisso.de/adhoc/uri/SmVuc2VuLCBNYXJ0aW4gU25lamJqZXJn|https://frl.publisso.de/adhoc/uri/RnUsIFF1YW5oYWk=|https://frl.publisso.de/adhoc/uri/R28sIFZpbnNvbg==|https://frl.publisso.de/adhoc/uri/TW9yaXppbywgSmFtZXM=|https://frl.publisso.de/adhoc/uri/U8O4cmVuc2VuLCBKZW5zIENocmlzdGlhbiBIZWRlbWFubg==|https://frl.publisso.de/adhoc/uri/U3Ryb2gsIEFsYnJlY2h0
1000 Label
1000 Förderer
  1. Zap Surgical Systems Inc. |
  2. Boehringer Ingelheim Stiftung |
  3. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. -
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Zap Surgical Systems Inc. |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Boehringer Ingelheim Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6428790.rdf
1000 Erstellt am 2021-08-06T14:48:31.038+0200
1000 Erstellt von 218
1000 beschreibt frl:6428790
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Thu Aug 18 07:39:55 CEST 2022
1000 Objekt bearb. Wed Aug 18 14:23:16 CEST 2021
1000 Vgl. frl:6428790
1000 Oai Id
  1. oai:frl.publisso.de:frl:6428790 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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