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Marron-et-al_2021_Vaccination and the Risk of Childhood Cancer.pdf 2,49MB
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1000 Titel
  • Vaccination and the Risk of Childhood Cancer—A Systematic Review and Meta-Analysis
1000 Autor/in
  1. Marron, Manuela |
  2. Brackmann, Lara Kim |
  3. Kuhse, Pia |
  4. Christianson, Lara |
  5. Langner, Ingo |
  6. Haug, Ulrike |
  7. Ahrens, Wolfgang |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-01-22
1000 Erschienen in
1000 Quellenangabe
  • 10:610843
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3389/fonc.2020.610843 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862764/ |
1000 Ergänzendes Material
  • https://www.frontiersin.org/articles/10.3389/fonc.2020.610843/full#supplementary-material |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: Infections may play a role in the etiology of childhood cancer and immunizations may be protective because vaccinations stimulate the immune system. Observational studies reported inconsistent associations between vaccination and risk of childhood cancer. Since a synthesis of the evidence is lacking, we conducted a meta-analysis stratified by histological and site-specific cancer. METHODS: We performed a systematic review (CRD42020148579) following PRISMA guidelines and searched for literature in MEDLINE, Embase, and the Science Citation Index databases. We identified in three literature databases 7,594 different articles of which 35 met the inclusion criteria allowing for 27 analyses of 11 cancer outcomes after exposure to nine different types of vaccinations. We calculated summary odds ratios (ORs) and 95% confidence intervals (CIs) using random effects models. RESULTS: We observed four inverse associations between childhood leukemia and certain vaccines as well as the number of vaccinations: OR 0.49 (95% CI = 0.32 to 0.74) for leukemia death after bacillus Calmette–Guérin vaccination; OR 0.76 (95% CI = 0.65 to 0.90) for acute lymphoblastic leukemia after Haemophilus influenzae type b vaccination; OR 0.57 (95% CI = 0.36 to 0.88) for leukemia; and OR 0.62 (95% CI = 0.46 to 0.85) for acute lymphoblastic leukemia after three or more vaccinations of any type. All other conducted analyses did not show any associations. DISCUSSION: The results are consistent with the hypothesis that vaccinations reduce the risk of childhood leukemia. However, the robustness and validity of these results is limited due to the small number, substantial heterogeneity, and methodological limitations of available studies.
1000 Sacherschließung
lokal Immunization
lokal Immune system
lokal Acute lymphoblastic leukemia
lokal Leukemia death
lokal Childhood leukemia
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/TWFycm9uLCBNYW51ZWxh|https://orcid.org/0000-0002-0484-9891|https://frl.publisso.de/adhoc/uri/S3Voc2UsIFBpYQ==|https://orcid.org/0000-0002-7780-255X|https://orcid.org/0000-0001-8998-1236|https://orcid.org/0000-0002-1886-2923|https://orcid.org/0000-0003-3777-570X
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
  1. Vaccination and the Risk of Childhood Cancer—A Systematic Review and Meta-Analysis
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6429044.rdf
1000 Erstellt am 2021-08-30T11:56:45.991+0200
1000 Erstellt von 266
1000 beschreibt frl:6429044
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri Sep 10 07:41:29 CEST 2021
1000 Objekt bearb. Fri Sep 10 07:41:14 CEST 2021
1000 Vgl. frl:6429044
1000 Oai Id
  1. oai:frl.publisso.de:frl:6429044 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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