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1000 Titel
  • Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function
1000 Autor/in
  1. Richter, Anni |
  2. de Boer, Lieke |
  3. Guitart Masip, Marc |
  4. Behnisch, Gusalija |
  5. Seidenbecher, Constanze |
  6. Schott, Björn |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-07-24
1000 Erschienen in
1000 Quellenangabe
  • 128(11):1705-1720
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00702-021-02382-4 |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007%2Fs00702-021-02382-4#Sec19 |
  • https://doi.org/10.1007/s00702-021-02398-w |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Dopaminergic neurotransmission plays a pivotal role in appetitively motivated behavior in mammals, including humans. Notably, action and valence are not independent in motivated tasks, and it is particularly difficult for humans to learn the inhibition of an action to obtain a reward. We have previously observed that the carriers of the DRD2/ANKK1 TaqIA A1 allele, that has been associated with reduced striatal dopamine D2 receptor expression, showed a diminished learning performance when required to learn response inhibition to obtain rewards, a finding that was replicated in two independent cohorts. With our present study, we followed two aims: first, we aimed to replicate our finding on the DRD2/ANKK1 TaqIA polymorphism in a third independent cohort (N = 99) and to investigate the nature of the genetic effects more closely using trial-by-trial behavioral analysis and computational modeling in the combined dataset (N = 281). Second, we aimed to assess a potentially modulatory role of prefrontal dopamine availability, using the widely studied COMT Val108/158Met polymorphism as a proxy. We first report a replication of the above mentioned finding. Interestingly, after combining all three cohorts, exploratory analyses regarding the COMT Val108/158Met polymorphism suggest that homozygotes for the Met allele, which has been linked to higher prefrontal dopaminergic tone, show a lower learning bias. Our results corroborate the importance of genetic variability of the dopaminergic system in individual learning differences of action-valence interaction and, furthermore, suggest that motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function.
1000 Sacherschließung
lokal Reward learning
lokal COMT
lokal Action bias
lokal TaqIA
lokal Dopamine D2 receptor
lokal Motivated learning
1000 Volltext
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536632/ |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-9681-6298|https://orcid.org/0000-0003-3381-2040|https://orcid.org/0000-0002-2294-6492|https://frl.publisso.de/adhoc/uri/QmVobmlzY2gsIEd1c2FsaWph|https://orcid.org/0000-0002-7433-2716|https://orcid.org/0000-0002-8237-4481
1000 Label
1000 Förderer
  1. Projekt DEAL |
  2. Deutsche Forschungsgemeinschaft |
  3. European Regional Development Fund |
  4. Vetenskapsrådet |
1000 Fördernummer
  1. -
  2. SFB 779/A08; SFB1436/A05; RI 2964-1
  3. -
  4. VT521-2013-2589
1000 Förderprogramm
  1. Open Access Funding
  2. -
  3. Autonomy in Old Age
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access Funding
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer SFB 779/A08; SFB1436/A05; RI 2964-1
  3. 1000 joinedFunding-child
    1000 Förderer European Regional Development Fund |
    1000 Förderprogramm Autonomy in Old Age
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Vetenskapsrådet |
    1000 Förderprogramm -
    1000 Fördernummer VT521-2013-2589
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6430020.rdf
1000 Erstellt am 2021-10-28T11:13:12.889+0200
1000 Erstellt von 242
1000 beschreibt frl:6430020
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Tue Nov 02 14:37:15 CET 2021
1000 Objekt bearb. Tue Nov 02 14:06:25 CET 2021
1000 Vgl. frl:6430020
1000 Oai Id
  1. oai:frl.publisso.de:frl:6430020 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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