fncel-15-746198.pdf 956,12KB
1000 Titel
  • Retrograde Amnesia - A Question of Disturbed Calcium Levels?
1000 Autor/in
  1. Montag, Dirk |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-17
1000 Erschienen in
1000 Quellenangabe
  • 15:746198
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Retrograde amnesia is the inability to remember events or information. The successful acquisition and memory of information is required before retrograde amnesia may occur. Often, the trigger for retrograde amnesia is a traumatic event. Loss of memories may be caused in two ways: either by loss/erasure of the memory itself or by the inability to access the memory, which is still present. In general, memories and learning are associated with a positive connotation although the extinction of unpleasant experiences and memories of traumatic events may be highly welcome. In contrast to the many experimental models addressing learning deficits caused by anterograde amnesia, the incapability to acquire new information, retrograde amnesia could so far only be investigated sporadically in human patients and in a limited number of model systems. Apart from models and diseases in which neurodegeneration or dementia like Alzheimer's disease result in loss of memory, retrograde amnesia can be elicited by various drugs of which alcohol is the most prominent one and exemplifies the non-specific effects and the variable duration. External or internal impacts like traumatic brain injury, stroke, or electroconvulsive treatments may similarly result in variable degrees of retrograde amnesia. In this review, I will discuss a new genetic approach to induce retrograde amnesia in a mouse model and raise the hypothesis that retrograde amnesia is caused by altered intracellular calcium homeostasis. Recently, we observed that neuronal loss of neuroplastin resulted in retrograde amnesia specifically for associative memories. Neuroplastin is tightly linked to the expression of the main Ca2+ extruding pumps, the plasma membrane calcium ATPases (PMCAs). Therefore, neuronal loss of neuroplastin may block the retrieval and storage of associative memories by interference with Ca2+ signaling cascades. The possibility to elicit retrograde amnesia in a controlled manner allows to investigate the underlying mechanisms and may provide a deeper understanding of the molecular and circuit processes of memory.
1000 Sacherschließung
lokal dementia
lokal retrograde amnesia
lokal neuroplastin
lokal post-traumatic stress disorder (PTSD)
lokal PMCA
lokal associative memory
lokal memory loss
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Bundesministerium für Bildung und Forschung |
1000 Fördernummer
  1. -
1000 Förderprogramm
1000 Dateien
  1. Retrograde Amnesia - A Question of Disturbed Calcium Levels?
1000 Förderung
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    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm CONICYT
    1000 Fördernummer -
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1000 Erstellt am 2022-01-12T14:52:29.038+0100
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