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1000 Titel
  • Comirnaty-Elicited and Convalescent Sera Recognize Different Spike Epitopes
1000 Autor/in
  1. Hein, Sascha |
  2. Benz, Nuka Ivalu |
  3. Eisert, Jonathan |
  4. Herrlein, Marie-Luise |
  5. Oberle, Doris Franziska |
  6. Dreher, Michael |
  7. Stingl, Julia |
  8. Hildt, Christoph |
  9. hildt, eberhard |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-01
1000 Erschienen in
1000 Quellenangabe
  • 9(12):1419
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.3390/vaccines9121419 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708883/ |
1000 Ergänzendes Material
  • https://www.mdpi.com/2076-393X/9/12/1419#supplementary |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Many of the approved SARS-CoV-2 vaccines are based on a stabilized variant of the spike protein. This raises the question of whether the immune response against the stabilized spike is identical to the immune response that is elicited by the native spike in the case of a SARS-CoV-2 infection. Using a peptide array-based approach, we analysed the binding of antibodies from Comirnaty-elicited, convalescent, and control sera to the peptides covering the spike protein. A total of 37 linear epitopes were identified. A total of 26 of these epitopes were almost exclusively recognized by the convalescent sera. Mapping these epitopes to the spike structures revealed that most of these 26 epitopes are masked in the pre-fusion structure. In particular, in the conserved central helix, three epitopes that are only exposed in the post-fusion conformation were identified. This indicates a higher spike-specific antibody diversity in convalescent sera. These differences could be relevant for the breadth of spike-specific immune response.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal peptide array
lokal convalescent
lokal linear epitopes
lokal SARS-CoV-2 spike
lokal stabilized spike protein
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7257-4538|https://frl.publisso.de/adhoc/uri/QmVueiwgTnVrYSBJdmFsdQ==|https://frl.publisso.de/adhoc/uri/RWlzZXJ0LCBKb25hdGhhbg==|https://orcid.org/0000-0003-2466-5114|https://d-nb.info/gnd/141799676|https://orcid.org/0000-0002-3452-5329|https://orcid.org/0000-0002-1566-8156|https://frl.publisso.de/adhoc/uri/SGlsZHQsIENocmlzdG9waA==|https://orcid.org/0000-0002-3020-9564
1000 Label
1000 Förderer
  1. Bundesministerium für Gesundheit |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. VARIPATH
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Gesundheit |
    1000 Förderprogramm VARIPATH
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6431848.rdf
1000 Erstellt am 2022-03-01T12:33:30.261+0100
1000 Erstellt von 323
1000 beschreibt frl:6431848
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet 2022-03-15T07:46:43.365+0100
1000 Objekt bearb. Tue Mar 15 07:46:43 CET 2022
1000 Vgl. frl:6431848
1000 Oai Id
  1. oai:frl.publisso.de:frl:6431848 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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