Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity

  1. Lyons, Sarah ORCID logo
  2. Datema, Mareen ORCID logo
  3. Le, Thuy-My ORCID logo
  4. Asero, Riccardo
  5. Barreales, Laura ORCID logo
  6. Belohlavkova, Simona ORCID logo
  7. de BLAY, Frédéric ORCID logo
  8. Clausen, Michael
  9. Dubakiene, Ruta
  10. Fernández-Perez, Cristina
  11. Fritsche, Philipp
  12. Gislason, David
  13. Hoffmann-Sommergruber, Karin ORCID logo
  14. Jedrzejczak-Czechowicz, Monika ORCID logo
  15. Zuidmeer-Jongejan, Laurian ORCID logo
  16. Kowalski, Marek ORCID logo
  17. Kralimarkova, Tanya ORCID logo
  18. Lidholm, Jonas ORCID logo
  19. Papadopoulos, Nikolaos G.
  20. Pontoppidan, Bo
  21. Popov, Todor ORCID logo
  22. Del Prado, Nayade
  23. Purohit, Ashok
  24. Reig, Isabel
  25. Seneviratne, Suranjith L.
  26. Sinaniotis, Athanasios
  27. Vassilopoulou, Emilia
  28. Versteeg, Serge A.
  29. Vieths, Stefan
  30. Zwinderman, Aeilko H ORCID logo
  31. Welsing, Paco ORCID logo
  32. Mills, E. N. Clare
  33. Ballmer-Weber, Barbara ORCID logo
  34. Knulst, André ORCID logo
  35. Fernandez-Rivas, Montserrat ORCID logo
  36. van Ree, Ronald ORCID logo

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1000 Titel
  • Walnut Allergy Across Europe: Distribution of Allergen Sensitization Patterns and Prediction of Severity
1000 Autor/in
  1. Lyons, Sarah |
  2. Datema, Mareen |
  3. Le, Thuy-My |
  4. Asero, Riccardo |
  5. Barreales, Laura |
  6. Belohlavkova, Simona |
  7. de BLAY, Frédéric |
  8. Clausen, Michael |
  9. Dubakiene, Ruta |
  10. Fernández-Perez, Cristina |
  11. Fritsche, Philipp |
  12. Gislason, David |
  13. Hoffmann-Sommergruber, Karin |
  14. Jedrzejczak-Czechowicz, Monika |
  15. Zuidmeer-Jongejan, Laurian |
  16. Kowalski, Marek |
  17. Kralimarkova, Tanya |
  18. Lidholm, Jonas |
  19. Papadopoulos, Nikolaos G. |
  20. Pontoppidan, Bo |
  21. Popov, Todor |
  22. Del Prado, Nayade |
  23. Purohit, Ashok |
  24. Reig, Isabel |
  25. Seneviratne, Suranjith L. |
  26. Sinaniotis, Athanasios |
  27. Vassilopoulou, Emilia |
  28. Versteeg, Serge A. |
  29. Vieths, Stefan |
  30. Zwinderman, Aeilko H |
  31. Welsing, Paco |
  32. Mills, E. N. Clare |
  33. Ballmer-Weber, Barbara |
  34. Knulst, André |
  35. Fernandez-Rivas, Montserrat |
  36. van Ree, Ronald |
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-09-08
1000 Erschienen in
1000 Quellenangabe
  • 9(1):225-235.e10
1000 FRL-Sammlung
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.jaip.2020.08.051 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Walnut allergy is common across the globe, but data on the involvement of individual walnut components are scarce. OBJECTIVES: To identify geographical differences in walnut component sensitization across Europe, explore cosensitization and cross-reactivity, and assess associations of clinical and serological determinants with severity of walnut allergy. METHODS: As part of the EuroPrevall outpatient surveys in 12 European cities, standardized clinical evaluation was conducted in 531 individuals reporting symptoms to walnut, with sensitization to all known walnut components assessed in 202 subjects. Multivariable Lasso regression was applied to investigate predictors for walnut allergy severity. RESULTS: Birch-pollen–related walnut sensitization (Jug r 5) dominated in Northern and Central Europe and lipid transfer protein sensitization (Jug r 3) in Southern Europe. Profilin sensitization (Jug r 7) was prominent throughout Europe. Sensitization to storage proteins (Jug r 1, 2, 4, and 6) was detected in up to 10% of subjects. The walnut components that showed strong correlations with pollen and other foods differed between centers. The combination of determinants best predicting walnut allergy severity were symptoms upon skin contact with walnut, atopic dermatitis (ever), family history of atopic disease, mugwort pollen allergy, sensitization to cat or dog, positive skin prick test result to walnut, and IgE to Jug r 1, 5, 7, or carbohydrate determinants (area under the curve = 0.81; 95% CI, 0.73-0.89). CONCLUSIONS: Walnut-allergic subjects across Europe show clear geographical differences in walnut component sensitization and cosensitization patterns. A predictive model combining results from component-based serology testing with results from extract-based testing and information on clinical background allows for good discrimination between mild to moderate and severe walnut allergy.
1000 Sacherschließung
lokal EuroPrevall
lokal Severity
lokal Allergen components
lokal Europe
lokal iFAAM
gnd 4034871-4 Lebensmittelallergie
lokal IgE sensitization
lokal Walnut allergy
lokal Prediction
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-7128-2699|https://orcid.org/0000-0003-2646-9467|https://orcid.org/0000-0001-6571-220X|https://frl.publisso.de/adhoc/uri/QXNlcm8sIFJpY2NhcmRv|https://orcid.org/0000-0002-8323-8449|https://orcid.org/0000-0003-2125-6614|https://orcid.org/0000-0001-5678-2214|https://frl.publisso.de/adhoc/uri/Q2xhdXNlbiwgTWljaGFlbA==|https://frl.publisso.de/adhoc/uri/RHViYWtpZW5lLCBSdXRh|https://frl.publisso.de/adhoc/uri/RmVybsOhbmRlei1QZXJleiwgQ3Jpc3RpbmEgIA==|https://frl.publisso.de/adhoc/uri/ICBGcml0c2NoZSwgUGhpbGlwcCAg|https://frl.publisso.de/adhoc/uri/ICBHaXNsYXNvbiwgRGF2aWQgIA==|https://orcid.org/0000-0002-8830-058X|https://orcid.org/0000-0003-2292-2770|https://orcid.org/0000-0003-3245-5555|https://orcid.org/0000-0002-8442-2774|https://orcid.org/0000-0001-7023-1574|https://orcid.org/0000-0002-7779-3411|https://frl.publisso.de/adhoc/uri/IFBhcGFkb3BvdWxvcywgTmlrb2xhb3MgRy4gICAgIA==|https://frl.publisso.de/adhoc/uri/UG9udG9wcGlkYW4sIEJvICAgIA==|https://orcid.org/0000-0001-5052-5866|https://frl.publisso.de/adhoc/uri/IERlbCBQcmFkbywgTmF5YWRlICAg|https://frl.publisso.de/adhoc/uri/ICBQdXJvaGl0LCBBc2hvayAgICA=|https://frl.publisso.de/adhoc/uri/ICBSZWlnLCBJc2FiZWwgICAg|https://frl.publisso.de/adhoc/uri/IFNlbmV2aXJhdG5lLCBTdXJhbmppdGggTC4gICAg|https://frl.publisso.de/adhoc/uri/IFNpbmFuaW90aXMsIEF0aGFuYXNpb3MgICAg|https://frl.publisso.de/adhoc/uri/ICAgVmFzc2lsb3BvdWxvdSwgRW1pbGlhICAg|https://frl.publisso.de/adhoc/uri/ICAgVmVyc3RlZWcsIFNlcmdlIEEuICAgIA==|https://d-nb.info/gnd/143949705|https://orcid.org/0000-0003-0361-3139|https://orcid.org/0000-0003-2361-2803|https://frl.publisso.de/adhoc/uri/ICBNaWxscywgRS4gTi4gQ2xhcmUgICA=|https://orcid.org/0000-0002-4136-5036|https://orcid.org/0000-0002-1056-3179|https://orcid.org/0000-0003-1748-2328|https://orcid.org/0000-0003-0767-0894
1000 Label
1000 Förderer
  1. Sixth Framework Programme |
  2. Seventh Framework Programme |
  3. EuroFIR (European Food Information Resource) |
1000 Fördernummer
  1. FP6-FOOD-CT-2005-514000
  2. -
  3. 312147
1000 Förderprogramm
  1. EuroPrevall
  2. -
  3. iFAAM
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Sixth Framework Programme |
    1000 Förderprogramm EuroPrevall
    1000 Fördernummer FP6-FOOD-CT-2005-514000
  2. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer EuroFIR (European Food Information Resource) |
    1000 Förderprogramm iFAAM
    1000 Fördernummer 312147
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432044.rdf
1000 Erstellt am 2022-03-08T15:12:37.586+0100
1000 Erstellt von 323
1000 beschreibt frl:6432044
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Tue Mar 22 07:42:18 CET 2022
1000 Objekt bearb. Tue Mar 22 07:41:56 CET 2022
1000 Vgl. frl:6432044
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432044 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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