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1000 Titel
  • Antibody response to SARS-CoV-2 for more than one year - kinetics and persistence of detection are predominantly determined by avidity progression and test design
1000 Autor/in
  1. Scheiblauer, Heinrich |
  2. Nübling, Claudius Micha |
  3. Wolf, Timo |
  4. Khodamoradi, Yascha |
  5. Bellinghausen, Carla |
  6. Sonntagbauer, Michael |
  7. Esser-Nobis, Katharina |
  8. Filomena, Angela |
  9. Mahler, Vera |
  10. Maier, Thorsten Jürgen |
  11. Stephan, Christoph |
1000 Erscheinungsjahr 2021
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-04
1000 Erschienen in
1000 Quellenangabe
  • 146:105052
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.jcv.2021.105052 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642248/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Antibody detection of SARS-CoV-2 requires an understanding of its variation, course, and duration. METHODS: Antibody response to SARS-CoV-2 was evaluated over 5–430 days on 828 samples across COVID-19 severity levels, for total antibody (TAb), IgG, IgA, IgM, neutralizing antibody (NAb), antibody avidity, and for receptor-binding-domain (RBD), spike (S), or nucleoprotein (N). Specificity was determined on 676 pre-pandemic samples. RESULTS: Sensitivity at 30–60 days post symptom onset (pso) for TAb-S/RBD, TAb-N, IgG-S, IgG-N, IgA-S, IgM-RBD, and NAb was 96.6%, 99.5%, 89.7%, 94.3%, 80.9%, 76.9% and 92.8%, respectively. Follow-up 430 days pso revealed: TAb-S/RBD increased slightly (100.0%); TAb-N decreased slightly (97.1%); IgG-S and IgA-S decreased moderately (81.4%, 65.7%); NAb remained positive (94.3%), slightly decreasing in activity after 300 days; there was correlation with IgG-S (Rs = 0.88) and IgA-S (Rs = 0.71); IgG-N decreased significantly from day 120 (15.7%); IgM-RBD dropped after 30–60 days (22.9%). High antibody avidity developed against S/RBD steadily with time in 94.3% of patients after 430 days. This correlated with persistent antibody detection depending on antibody-binding efficiency of the test design. Severe COVID-19 correlated with earlier and higher antibody response, mild COVID-19 was heterogeneous with a wide range of antibody reactivities. Specificity of the tests was ≥99%, except for IgA (96%). CONCLUSION: Sensitivity of anti-SARS-CoV-2 assays was determined by test design, target antigen, antibody avidity, and COVID-19 severity. Sustained antibody detection was mainly determined by avidity progression for RBD and S. Testing by TAb and for S/RBD provided the highest sensitivity and longest detection duration of 14 months so far.
1000 Sacherschließung
gnd 1206347392 COVID-19
lokal Persistence SARS-CoV-2 antibodies
lokal Sensitivity
lokal Specificity
lokal Antibody avidity
lokal neutralization
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-1624-8310|https://orcid.org/0000-0002-5892-4105|https://orcid.org/0000-0002-3819-9540|https://orcid.org/0000-0001-5972-0967|https://orcid.org/0000-0001-8025-2846|https://orcid.org/0000-0001-8772-1844|https://orcid.org/0000-0002-9027-0391|https://orcid.org/0000-0002-2301-4021|https://d-nb.info/gnd/1115010409|https://orcid.org/0000-0003-3234-947X|https://orcid.org/0000-0003-3777-9006
1000 Label
1000 Förderer
  1. Bundesministerium für Gesundheit |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Gesundheit |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432219.rdf
1000 Erstellt am 2022-03-15T09:48:24.873+0100
1000 Erstellt von 323
1000 beschreibt frl:6432219
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet 2022-04-06T15:44:17.165+0200
1000 Objekt bearb. Wed Apr 06 15:44:05 CEST 2022
1000 Vgl. frl:6432219
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432219 |
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