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WeightNameValue
1000 Titel
  • HPV caught in the tetraspanin web?
1000 Autor/in
  1. Finke, Jérôme |
  2. Hitschler, Lisa |
  3. Boller, Klaus |
  4. Florin, Luise |
  5. Lang, Thorsten |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-13
1000 Erschienen in
1000 Quellenangabe
  • 209(4):447-459
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00430-020-00683-1 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293171/ |
1000 Ergänzendes Material
  • https://link.springer.com/article/10.1007/s00430-020-00683-1#Sec14 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Tetraspanins are master organizers of the cell membrane. Recent evidence suggests that tetraspanins themselves may become crowded by virus particles and that these crowds/aggregates co-internalize with the viral particles. Using microscopy, we studied human papillomavirus (HPV) type 16-dependent aggregates on the cell surface of tetraspanin overexpressing keratinocytes. We find that aggregates are (1) rich in at least two different tetraspanins, (2) three-dimensional architectures extending up to several micrometers into the cell, and (3) decorated intracellularly by filamentous actin. Moreover, in cells not overexpressing tetraspanins, we note that obscurin-like protein 1 (OBSL1), which is thought to be a cytoskeletal adaptor, associates with filamentous actin. We speculate that HPV contact with the cell membrane could trigger the formation of a large tetraspanin web. This web may couple the virus contact site to the intracellular endocytic actin machinery, possibly involving the cytoskeletal adaptor protein OBSL1. Functionally, such a tetraspanin web could serve as a virus entry platform, which is co-internalized with the virus particle.
1000 Sacherschließung
lokal Protein nanoclustering
lokal CD63
lokal Papillomavirus
gnd 4188401-2 Virusinfektion
lokal Microdomains
lokal Pathogen endocytosis
lokal Actin
lokal CD151
lokal OBSL1
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-9528-5763|https://frl.publisso.de/adhoc/uri/SGl0c2NobGVyLCBMaXNhICA=|https://orcid.org/0000-0002-0161-2565|https://orcid.org/0000-0003-4310-7329|https://frl.publisso.de/adhoc/uri/TGFuZywgVGhvcnN0ZW4gIA==
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft |
  2. Projekt DEAL |
1000 Fördernummer
  1. FL 696/3-1; LA 1272/8-1
  2. -
1000 Förderprogramm
  1. -
  2. Open access funding
1000 Dateien
  1. HPV caught in the tetraspanin web?
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer FL 696/3-1; LA 1272/8-1
  2. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open access funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6432584.rdf
1000 Erstellt am 2022-03-28T16:36:25.942+0200
1000 Erstellt von 323
1000 beschreibt frl:6432584
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Thu May 05 08:23:32 CEST 2022
1000 Objekt bearb. Thu May 05 08:23:05 CEST 2022
1000 Vgl. frl:6432584
1000 Oai Id
  1. oai:frl.publisso.de:frl:6432584 |
1000 Sichtbarkeit Metadaten public
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