Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study

  1. Castaño-Vinyals, Gemma ORCID logo
  2. Sadetzki, Siegal
  3. Vermeulen, Roel
  4. Momoli, Franco
  5. Kundi, Michael ORCID logo
  6. Merletti, Franco
  7. Maslanyj, Myron ORCID logo
  8. Calderon, Carolina ORCID logo
  9. Wiart, Joe
  10. Lee, Ae-kyoung
  11. Taki, Masao
  12. Sim, Malcolm ORCID logo
  13. Armstrong, Bruce ORCID logo
  14. Benke, Geza
  15. Schattner, Rosa ORCID logo
  16. Hutter, Hans-Peter
  17. Krewski, Daniel
  18. Mohipp, Charmaine
  19. Ritvo, Paul ORCID logo
  20. Spinelli, John
  21. Lacour, Brigitte
  22. Remen, Thomas
  23. Radon, Katja ORCID logo
  24. Weinmann, Tobias ORCID logo
  25. Petridou, Eleni Th.
  26. Moschovi, Maria
  27. Pourtsidis, Apostolos
  28. Oikonomou, Konstantinos ORCID logo
  29. Kanavidis, Prodromos ORCID logo
  30. Bouka, Evdoxia
  31. Dikshit, Rajesh ORCID logo
  32. Nagrani, Rajini ORCID logo
  33. Chetrit, Angela
  34. Bruchim, Revital ORCID logo
  35. Maule, Milena
  36. Migliore, Enrica
  37. Filippini, Graziella
  38. Miligi, Lucia
  39. Mattioli, Stefano
  40. Kojimahara, Noriko ORCID logo
  41. Yamaguchi, Naohito
  42. Ha, Mina ORCID logo
  43. Choi, Kyung-Hwa ORCID logo
  44. Kromhout, Hans ORCID logo
  45. Geodhart, Geertje
  46. t'Mannetje, Andrea
  47. Eng, Amanda
  48. Eastman Langer, Chelsea
  49. Alguacil, Juan
  50. Aragonés, Núria
  51. Morales-Suarez-Varela, Maria
  52. Badia, F.
  53. Albert, Alex ORCID logo
  54. Carretero García, Gema ORCID logo
  55. Cardis, Elisabeth ORCID logo

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Castano-Vinyals-et-al_2022_Wireless phone use in childhood and adolescence.pdf 1,01MB
WeightNameValue
1000 Titel
  • Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study
1000 Autor/in
  1. Castaño-Vinyals, Gemma |
  2. Sadetzki, Siegal |
  3. Vermeulen, Roel |
  4. Momoli, Franco |
  5. Kundi, Michael |
  6. Merletti, Franco |
  7. Maslanyj, Myron |
  8. Calderon, Carolina |
  9. Wiart, Joe |
  10. Lee, Ae-kyoung |
  11. Taki, Masao |
  12. Sim, Malcolm |
  13. Armstrong, Bruce |
  14. Benke, Geza |
  15. Schattner, Rosa |
  16. Hutter, Hans-Peter |
  17. Krewski, Daniel |
  18. Mohipp, Charmaine |
  19. Ritvo, Paul |
  20. Spinelli, John |
  21. Lacour, Brigitte |
  22. Remen, Thomas |
  23. Radon, Katja |
  24. Weinmann, Tobias |
  25. Petridou, Eleni Th. |
  26. Moschovi, Maria |
  27. Pourtsidis, Apostolos |
  28. Oikonomou, Konstantinos |
  29. Kanavidis, Prodromos |
  30. Bouka, Evdoxia |
  31. Dikshit, Rajesh |
  32. Nagrani, Rajini |
  33. Chetrit, Angela |
  34. Bruchim, Revital |
  35. Maule, Milena |
  36. Migliore, Enrica |
  37. Filippini, Graziella |
  38. Miligi, Lucia |
  39. Mattioli, Stefano |
  40. Kojimahara, Noriko |
  41. Yamaguchi, Naohito |
  42. Ha, Mina |
  43. Choi, Kyung-Hwa |
  44. Kromhout, Hans |
  45. Geodhart, Geertje |
  46. t'Mannetje, Andrea |
  47. Eng, Amanda |
  48. Eastman Langer, Chelsea |
  49. Alguacil, Juan |
  50. Aragonés, Núria |
  51. Morales-Suarez-Varela, Maria |
  52. Badia, F. |
  53. Albert, Alex |
  54. Carretero García, Gema |
  55. Cardis, Elisabeth |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-12-30
1000 Erschienen in
1000 Quellenangabe
  • 160:107069
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.envint.2021.107069 |
1000 Ergänzendes Material
  • https://www.sciencedirect.com/science/article/pii/S0160412021006942?via%3Dihub#s0075 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In recent decades, the possibility that use of mobile communicating devices, particularly wireless (mobile and cordless) phones, may increase brain tumour risk, has been a concern, particularly given the considerable increase in their use by young people. MOBI-Kids, a 14-country (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, the Netherlands, New Zealand, Spain) case-control study, was conducted to evaluate whether wireless phone use (and particularly resulting exposure to radiofrequency (RF) and extremely low frequency (ELF) electromagnetic fields (EMF)) increases risk of brain tumours in young people. Between 2010 and 2015, the study recruited 899 people with brain tumours aged 10 to 24 years old and 1,910 controls (operated for appendicitis) matched to the cases on date of diagnosis, study region and age. Participation rates were 72% for cases and 54% for controls. The mean ages of cases and controls were 16.5 and 16.6 years, respectively; 57% were males. The vast majority of study participants were wireless phones users, even in the youngest age group, and the study included substantial numbers of long-term (over 10 years) users: 22% overall, 51% in the 20–24-year-olds. Most tumours were of the neuroepithelial type (NBT; n = 671), mainly glioma. The odds ratios (OR) of NBT appeared to decrease with increasing time since start of use of wireless phones, cumulative number of calls and cumulative call time, particularly in the 15–19 years old age group. A decreasing trend in ORs was also observed with increasing estimated cumulative RF specific energy and ELF induced current density at the location of the tumour. Further analyses suggest that the large number of ORs below 1 in this study is unlikely to represent an unknown causal preventive effect of mobile phone exposure: they can be at least partially explained by differential recall by proxies and prodromal symptoms affecting phone use before diagnosis of the cases. We cannot rule out, however, residual confounding from sources we did not measure. Overall, our study provides no evidence of a causal association between wireless phone use and brain tumours in young people. However, the sources of bias summarised above prevent us from ruling out a small increased risk.
1000 Sacherschließung
lokal Wireless phones
lokal Brain tumours
lokal Young people
lokal Extremely low frequency electromagnetic fields
lokal Mobile phones
lokal Radiofrequency radiation
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-4468-1816|https://frl.publisso.de/adhoc/uri/U2FkZXR6a2ksIFNpZWdhbA==|https://frl.publisso.de/adhoc/uri/VmVybWV1bGVuLCBSb2Vs|https://frl.publisso.de/adhoc/uri/TW9tb2xpLCBGcmFuY28=|https://orcid.org/0000-0002-2707-3213|https://frl.publisso.de/adhoc/uri/TWVybGV0dGksIEZyYW5jbw==|https://orcid.org/0000-0002-9909-9615|https://orcid.org/0000-0001-9707-0918|https://frl.publisso.de/adhoc/uri/V2lhcnQsIEpvZQ==|https://frl.publisso.de/adhoc/uri/TGVlLCBBZS1reW91bmc=|https://frl.publisso.de/adhoc/uri/VGFraSwgTWFzYW8=|https://orcid.org/0000-0003-4739-2817|https://orcid.org/0000-0001-8940-7525|https://frl.publisso.de/adhoc/uri/QmVua2UsIEdlemE=|https://orcid.org/0000-0003-0107-9243|https://frl.publisso.de/adhoc/uri/SHV0dGVyLCBIYW5zLVBldGVy|https://frl.publisso.de/adhoc/uri/S3Jld3NraSwgRGFuaWVs|https://frl.publisso.de/adhoc/uri/TW9oaXBwLCBDaGFybWFpbmU=|https://orcid.org/0000-0003-1141-0083|https://frl.publisso.de/adhoc/uri/U3BpbmVsbGksIEpvaG4=|https://frl.publisso.de/adhoc/uri/TGFjb3VyLCBCcmlnaXR0ZQ==|https://frl.publisso.de/adhoc/uri/UmVtZW4sIFRob21hcw==|https://orcid.org/0000-0002-5271-3972|https://orcid.org/0000-0002-4582-5191|https://frl.publisso.de/adhoc/uri/UGV0cmlkb3UsIEVsZW5pIFRoLg==|https://frl.publisso.de/adhoc/uri/TW9zY2hvdmksIE1hcmlh|https://frl.publisso.de/adhoc/uri/UG91cnRzaWRpcywgQXBvc3RvbG9z|https://orcid.org/0000-0001-7691-0674|https://orcid.org/0000-0002-2819-472X|https://frl.publisso.de/adhoc/uri/Qm91a2EsIEV2ZG94aWE=|https://orcid.org/0000-0003-4830-0486|https://orcid.org/0000-0002-1708-2319|https://frl.publisso.de/adhoc/uri/Q2hldHJpdCwgQW5nZWxh|https://orcid.org/0000-0002-0331-0165|https://frl.publisso.de/adhoc/uri/TWF1bGUsIE1pbGVuYQ==|https://frl.publisso.de/adhoc/uri/TWlnbGlvcmUsIEVucmljYQ==|https://frl.publisso.de/adhoc/uri/RmlsaXBwaW5pLCBHcmF6aWVsbGE=|https://frl.publisso.de/adhoc/uri/TWlsaWdpLCBMdWNpYQ==|https://frl.publisso.de/adhoc/uri/TWF0dGlvbGksIFN0ZWZhbm8=|https://orcid.org/0000-0003-4099-6167|https://frl.publisso.de/adhoc/uri/WWFtYWd1Y2hpLCBOYW9oaXRv|https://orcid.org/0000-0003-1011-9446|https://orcid.org/0000-0001-8206-4574|https://orcid.org/0000-0002-4233-1890|https://frl.publisso.de/adhoc/uri/R2VvZGhhcnQsIEdlZXJ0amU=|https://frl.publisso.de/adhoc/uri/dCdNYW5uZXRqZSwgQW5kcmVh|https://frl.publisso.de/adhoc/uri/RW5nLCBBbWFuZGE=|https://frl.publisso.de/adhoc/uri/RWFzdG1hbiBMYW5nZXIsIENoZWxzZWE=|https://frl.publisso.de/adhoc/uri/QWxndWFjaWwsIEp1YW4=|https://frl.publisso.de/adhoc/uri/QXJhZ29uw6lzLCBOw7pyaWE=|https://frl.publisso.de/adhoc/uri/TW9yYWxlcy1TdWFyZXotVmFyZWxhLCBNYXJpYQ==|https://frl.publisso.de/adhoc/uri/QmFkaWEsIEYu|https://orcid.org/0000-0001-5178-9679|https://orcid.org/0000-0003-4425-1437|https://orcid.org/0000-0003-0999-6839
1000 (Academic) Editor
1000 Label
1000 Förderer
  1. Seventh Framework Programme |
  2. Ministerio de Ciencia e Innovación |
  3. Instituto de Salud Carlos III |
  4. Consejería de Salud y Familias, Junta de Andalucía |
  5. Generalitat de Catalunya |
  6. Agència de Gestió d'Ajuts Universitaris i de Recerca |
  7. National Health and Medical Research Council |
  8. Bundesministerium für Bildung, Wissenschaft und Forschung |
  9. Canadian Institutes of Health Research |
  10. Canadian Wireless Telecommunications Association |
  11. Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail |
  12. Institut National Du Cancer |
  13. Pfizer Foundation |
  14. Ligue Contre le Cancer |
  15. Bundesamt für Strahlenschutz |
  16. Hellenic Society for Social Pediatrics and Health Promotion |
  17. ELKE |
  18. GGET |
  19. Board of Research in Nuclear Sciences |
  20. Ministero della Salute |
  21. Ministry of Science and ICT, South Korea |
  22. Ministry of Internal Affairs and Communications |
  23. Health Research Council of New Zealand |
  24. Cure Kids |
  25. ZonMw |
  26. ODAS Stichting |
1000 Fördernummer
  1. 226873; 603794
  2. CEX2018-000806-S
  3. -
  4. PI-0317-2010
  5. -
  6. 2017 SGR 1487
  7. 546130
  8. -
  9. 110835
  10. -
  11. FSRF2008-3
  12. -
  13. -
  14. -
  15. 3609S30010
  16. -
  17. -
  18. -
  19. 2013/38/01-BRNS
  20. RF-2009-1546284
  21. 2017-0-00961; 2019-0-00102
  22. 0155‐0107
  23. 12/380
  24. 3536
  25. 85800001
  26. -
1000 Förderprogramm
  1. -
  2. Centro de Excelencia Severo Ochoa 2019-2023
  3. Spanish Health Research Fund (FIS)
  4. -
  5. CERCA Program
  6. -
  7. -
  8. -
  9. -
  10. -
  11. -
  12. -
  13. -
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  18. -
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  20. -
  21. ICT R&D program
  22. Research on biological electromagnetic environment
  23. -
  24. -
  25. Electromagnetic Fields and Health Research
  26. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Seventh Framework Programme |
    1000 Förderprogramm -
    1000 Fördernummer 226873; 603794
  2. 1000 joinedFunding-child
    1000 Förderer Ministerio de Ciencia e Innovación |
    1000 Förderprogramm Centro de Excelencia Severo Ochoa 2019-2023
    1000 Fördernummer CEX2018-000806-S
  3. 1000 joinedFunding-child
    1000 Förderer Instituto de Salud Carlos III |
    1000 Förderprogramm Spanish Health Research Fund (FIS)
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Consejería de Salud y Familias, Junta de Andalucía |
    1000 Förderprogramm -
    1000 Fördernummer PI-0317-2010
  5. 1000 joinedFunding-child
    1000 Förderer Generalitat de Catalunya |
    1000 Förderprogramm CERCA Program
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Agència de Gestió d'Ajuts Universitaris i de Recerca |
    1000 Förderprogramm -
    1000 Fördernummer 2017 SGR 1487
  7. 1000 joinedFunding-child
    1000 Förderer National Health and Medical Research Council |
    1000 Förderprogramm -
    1000 Fördernummer 546130
  8. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung, Wissenschaft und Forschung |
    1000 Förderprogramm -
    1000 Fördernummer -
  9. 1000 joinedFunding-child
    1000 Förderer Canadian Institutes of Health Research |
    1000 Förderprogramm -
    1000 Fördernummer 110835
  10. 1000 joinedFunding-child
    1000 Förderer Canadian Wireless Telecommunications Association |
    1000 Förderprogramm -
    1000 Fördernummer -
  11. 1000 joinedFunding-child
    1000 Förderer Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail |
    1000 Förderprogramm -
    1000 Fördernummer FSRF2008-3
  12. 1000 joinedFunding-child
    1000 Förderer Institut National Du Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  13. 1000 joinedFunding-child
    1000 Förderer Pfizer Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  14. 1000 joinedFunding-child
    1000 Förderer Ligue Contre le Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  15. 1000 joinedFunding-child
    1000 Förderer Bundesamt für Strahlenschutz |
    1000 Förderprogramm -
    1000 Fördernummer 3609S30010
  16. 1000 joinedFunding-child
    1000 Förderer Hellenic Society for Social Pediatrics and Health Promotion |
    1000 Förderprogramm -
    1000 Fördernummer -
  17. 1000 joinedFunding-child
    1000 Förderer ELKE |
    1000 Förderprogramm -
    1000 Fördernummer -
  18. 1000 joinedFunding-child
    1000 Förderer GGET |
    1000 Förderprogramm -
    1000 Fördernummer -
  19. 1000 joinedFunding-child
    1000 Förderer Board of Research in Nuclear Sciences |
    1000 Förderprogramm -
    1000 Fördernummer 2013/38/01-BRNS
  20. 1000 joinedFunding-child
    1000 Förderer Ministero della Salute |
    1000 Förderprogramm -
    1000 Fördernummer RF-2009-1546284
  21. 1000 joinedFunding-child
    1000 Förderer Ministry of Science and ICT, South Korea |
    1000 Förderprogramm ICT R&D program
    1000 Fördernummer 2017-0-00961; 2019-0-00102
  22. 1000 joinedFunding-child
    1000 Förderer Ministry of Internal Affairs and Communications |
    1000 Förderprogramm Research on biological electromagnetic environment
    1000 Fördernummer 0155‐0107
  23. 1000 joinedFunding-child
    1000 Förderer Health Research Council of New Zealand |
    1000 Förderprogramm -
    1000 Fördernummer 12/380
  24. 1000 joinedFunding-child
    1000 Förderer Cure Kids |
    1000 Förderprogramm -
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    1000 Förderprogramm -
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1000 Objektart article
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1000 Erstellt am 2022-05-09T11:35:27.196+0200
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