Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)

  1. Olsson, Ann ORCID logo
  2. Guha, Neela ORCID logo
  3. Bouaoun, Liacine
  4. Kromhout, Hans ORCID logo
  5. Peters, Susan ORCID logo
  6. Siemiatycki, Jack ORCID logo
  7. Ho, Vikki ORCID logo
  8. Gustavsson, Per ORCID logo
  9. Boffetta, Paolo ORCID logo
  10. Vermeulen, Roel ORCID logo
  11. Behrens, Thomas ORCID logo
  12. Brüning, Thomas
  13. Kendzia, Benjamin ORCID logo
  14. Guenel, Pascal ORCID logo
  15. Luce, Danièle ORCID logo
  16. Karrasch, Stefan
  17. Wichmann, Heinz-Erich
  18. Consonni, Dario ORCID logo
  19. Landi, Maria Teresa
  20. Caporaso, Neil
  21. Merletti, Franco
  22. Mirabelli, Dario ORCID logo
  23. richiardi, lorenzo ORCID logo
  24. Jöckel, Karl-Heinz
  25. Ahrens, Wolfgang ORCID logo
  26. Pohlabeln, Hermann ORCID logo
  27. Tardon, Adonina ORCID logo
  28. Zaridze, David
  29. Field, John ORCID logo
  30. Lissowska, Jolanta ORCID logo
  31. Swiatkowska, Beata ORCID logo
  32. McLaughlin, John
  33. Demers, Paul
  34. Bencko, Vladimir
  35. Foretova, Lenka
  36. Janout, Vladimir
  37. Pándics, Tamás
  38. Fabianova, Eleonora ORCID logo
  39. Mates, Dana
  40. Forastiere, Francesco
  41. Bueno-de-Mesquita, H. Bas
  42. Schuz, Joachim ORCID logo
  43. Straif, Kurt

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1000 Titel
  • Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)
1000 Autor/in
  1. Olsson, Ann |
  2. Guha, Neela |
  3. Bouaoun, Liacine |
  4. Kromhout, Hans |
  5. Peters, Susan |
  6. Siemiatycki, Jack |
  7. Ho, Vikki |
  8. Gustavsson, Per |
  9. Boffetta, Paolo |
  10. Vermeulen, Roel |
  11. Behrens, Thomas |
  12. Brüning, Thomas |
  13. Kendzia, Benjamin |
  14. Guenel, Pascal |
  15. Luce, Danièle |
  16. Karrasch, Stefan |
  17. Wichmann, Heinz-Erich |
  18. Consonni, Dario |
  19. Landi, Maria Teresa |
  20. Caporaso, Neil |
  21. Merletti, Franco |
  22. Mirabelli, Dario |
  23. richiardi, lorenzo |
  24. Jöckel, Karl-Heinz |
  25. Ahrens, Wolfgang |
  26. Pohlabeln, Hermann |
  27. Tardon, Adonina |
  28. Zaridze, David |
  29. Field, John |
  30. Lissowska, Jolanta |
  31. Swiatkowska, Beata |
  32. McLaughlin, John |
  33. Demers, Paul |
  34. Bencko, Vladimir |
  35. Foretova, Lenka |
  36. Janout, Vladimir |
  37. Pándics, Tamás |
  38. Fabianova, Eleonora |
  39. Mates, Dana |
  40. Forastiere, Francesco |
  41. Bueno-de-Mesquita, H. Bas |
  42. Schuz, Joachim |
  43. Straif, Kurt |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-07-01
1000 Erschienen in
1000 Quellenangabe
  • 31(7):1433-1441
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1158/1055-9965.EPI-21-1428 |
1000 Ergänzendes Material
  • https://aacrjournals.org/cebp/article/31/7/1433/705146/Occupational-Exposure-to-Polycyclic-Aromatic#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project. METHODS: We pooled 14 case–control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada. Exposure to benzo[a]pyrene (BaP) was used as a proxy of PAH and estimated from a quantitative general population job-exposure matrix. Multivariable unconditional logistic regression models, adjusted for smoking and exposure to other occupational lung carcinogens, estimated ORs, and 95% confidence intervals (CI). RESULTS: We included 16,901 lung cancer cases and 20,965 frequency-matched controls. Adjusted OR for PAH exposure (ever) was 1.08 (CI, 1.02–1.15) in men and 1.20 (CI, 1.04–1.38) in women. When stratified by smoking status and histologic subtype, the OR for cumulative exposure ≥0.24 BaP μg/m3-years in men was higher in never smokers overall [1.31 (CI, 0.98–1.75)], for small cell [2.53 (CI, 1.28–4.99)] and squamous cell cancers [1.33 (CI, 0.80–2.21)]. Joint effects between PAH and smoking were observed. Restricting analysis to the most recent studies showed no increased risk. CONCLUSIONS: Elevated lung cancer risk associated with PAH exposure was observed in both sexes, particularly for small cell and squamous cell cancers, after accounting for cigarette smoking and exposure to other occupational lung carcinogens. IMPACT: The lack of association between PAH and lung cancer in more recent studies merits further research under today's exposure conditions and worker protection measures.
1000 Sacherschließung
lokal polycyclic aromatic hydrocarbons
lokal benzo[a]pyrene
lokal lung cancer
lokal occupational exposures
lokal case-control study
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0001-6498-2259|https://orcid.org/0000-0003-3991-4662|https://frl.publisso.de/adhoc/uri/Qm91YW91biwgTGlhY2luZQ==|https://orcid.org/0000-0002-4233-1890|https://orcid.org/0000-0001-5662-1971|https://orcid.org/0000-0002-9042-8582|https://orcid.org/0000-0002-0724-7917|https://orcid.org/0000-0003-2221-8599|https://orcid.org/0000-0002-3811-2791|https://orcid.org/0000-0003-4082-8163|https://orcid.org/0000-0002-4583-5234|https://frl.publisso.de/adhoc/uri/QnLDvG5pbmcsIFRob21hcw==|https://orcid.org/0000-0002-8662-795X|https://orcid.org/0000-0002-8359-518X|https://orcid.org/0000-0002-1708-4584|https://frl.publisso.de/adhoc/uri/S2FycmFzY2gsIFN0ZWZhbg==|https://frl.publisso.de/adhoc/uri/V2ljaG1hbm4sIEhlaW56LUVyaWNo|https://orcid.org/0000-0002-8935-3843|https://frl.publisso.de/adhoc/uri/TGFuZGksIE1hcmlhIFRlcmVzYQ==|https://frl.publisso.de/adhoc/uri/Q2Fwb3Jhc28sIE5laWw=|https://frl.publisso.de/adhoc/uri/TWVybGV0dGksIEZyYW5jbw==|https://orcid.org/0000-0003-2312-1342|https://orcid.org/0000-0003-0316-9402|https://frl.publisso.de/adhoc/uri/SsO2Y2tlbCwgS2FybC1IZWlueg==|https://orcid.org/0000-0003-3777-570X|https://orcid.org/0000-0002-9575-1119|https://orcid.org/0000-0001-5150-1209|https://frl.publisso.de/adhoc/uri/WmFyaWR6ZSwgRGF2aWQ=|https://orcid.org/0000-0003-3951-6365|https://orcid.org/0000-0003-2695-5799|https://orcid.org/0000-0003-3757-3868|https://frl.publisso.de/adhoc/uri/TWNMYXVnaGxpbiwgSm9obg==|https://frl.publisso.de/adhoc/uri/RGVtZXJzLCBQYXVs|https://frl.publisso.de/adhoc/uri/QmVuY2tvLCBWbGFkaW1pcg==|https://frl.publisso.de/adhoc/uri/Rm9yZXRvdmEsIExlbmth|https://frl.publisso.de/adhoc/uri/SmFub3V0LCBWbGFkaW1pcg==|https://frl.publisso.de/adhoc/uri/UMOhbmRpY3MsIFRhbcOhcw==|https://orcid.org/0000-0002-5519-8427|https://frl.publisso.de/adhoc/uri/TWF0ZXMsIERhbmE=|https://frl.publisso.de/adhoc/uri/Rm9yYXN0aWVyZSwgRnJhbmNlc2Nv|https://frl.publisso.de/adhoc/uri/QnVlbm8tZGUtTWVzcXVpdGEsIEguIEJhcw==|https://orcid.org/0000-0001-9687-2134|https://frl.publisso.de/adhoc/uri/U3RyYWlmLCBLdXJ0
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