Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness

  1. Streit, Fabian ORCID logo
  2. Witt, Stephanie ORCID logo
  3. Awasthi, Swapnil
  4. Foo, Jerome Clifford ORCID logo
  5. Jungkunz, Martin
  6. Frank, Josef ORCID logo
  7. Colodro Conde, Lucía ORCID logo
  8. Hindley, Guy ORCID logo
  9. Smeland, Olav Bjerkehagen ORCID logo
  10. Maslahati, Tolou
  11. Schwarze, Cornelia E.
  12. Dahmen, Norbert
  13. Schott, Björn ORCID logo
  14. Kleindienst, Nikolaus
  15. Hartmann, Annette
  16. Giegling, Ina
  17. Zillich, Lea
  18. Sirignano, Lea ORCID logo
  19. Poisel, Eric
  20. Chen, Chi-Hua
  21. Nöthen, Markus ORCID logo
  22. Mobascher, Arian
  23. Rujescu, Dan ORCID logo
  24. Lieb, Klaus
  25. Roepke, Stefan
  26. Schmahl, Christian
  27. Bohus, Martin
  28. Ripke, Stephan
  29. Rietschel, Marcella ORCID logo
  30. Andreassen, Ole A. ORCID logo

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1000 Titel
  • Borderline personality disorder and the big five: molecular genetic analyses indicate shared genetic architecture with neuroticism and openness
1000 Autor/in
  1. Streit, Fabian |
  2. Witt, Stephanie |
  3. Awasthi, Swapnil |
  4. Foo, Jerome Clifford |
  5. Jungkunz, Martin |
  6. Frank, Josef |
  7. Colodro Conde, Lucía |
  8. Hindley, Guy |
  9. Smeland, Olav Bjerkehagen |
  10. Maslahati, Tolou |
  11. Schwarze, Cornelia E. |
  12. Dahmen, Norbert |
  13. Schott, Björn |
  14. Kleindienst, Nikolaus |
  15. Hartmann, Annette |
  16. Giegling, Ina |
  17. Zillich, Lea |
  18. Sirignano, Lea |
  19. Poisel, Eric |
  20. Chen, Chi-Hua |
  21. Nöthen, Markus |
  22. Mobascher, Arian |
  23. Rujescu, Dan |
  24. Lieb, Klaus |
  25. Roepke, Stefan |
  26. Schmahl, Christian |
  27. Bohus, Martin |
  28. Ripke, Stephan |
  29. Rietschel, Marcella |
  30. Andreassen, Ole A. |
1000 Erscheinungsjahr 2022
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2022-04-11
1000 Erschienen in
1000 Quellenangabe
  • 12(1):153
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2022
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1038/s41398-022-01912-2 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001677/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41398-022-01912-2#Sec12 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Both environmental (e.g. interpersonal traumatization during childhood and adolescence) and genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/features in the general population indicate that genetic factors underlying these symptoms/features are shared in part with the personality traits of the Five Factor Model (FFM) of personality-the "Big Five". In the present study, the genetic overlap of BPD with the Big Five -Openness to Experience, Conscientiousness, Extraversion, Agreeableness, and Neuroticism- was assessed. Linkage disequilibrium score regression was used to calculate genetic correlations between a genome-wide association study (GWAS) in central European populations on BPD (N = 2543) and GWAS on the Big Five (N = 76,551-122,886, Neuroticism N = 390,278). Polygenic scores (PGS) were calculated to test the association of the genetic disposition for the personality traits with BPD case-control status. Significant positive genetic correlations of BPD were found with Neuroticism (rg = 0.34, p = 6.3*10-5) and Openness (rg = 0.24, p = 0.036), but not with the other personality traits (all | rg | <0.14, all p > 0.30). A cluster and item-level analysis showed positive genetic correlations of BPD with the Neuroticism clusters "Depressed Affect" and "Worry", and with a broad range of Neuroticism items (N = 348,219-376,352). PGS analyses confirmed the genetic correlations, and found an independent contribution of the personality traits to BPD risk. The observed associations indicate a partially shared genetic background of BPD and the personality traits Neuroticism and Openness. Larger GWAS of BPD and the "Big Five" are needed to further explore the role of personality traits in the etiology of BPD.
1000 Sacherschließung
lokal Psychiatric disorders
lokal Clinical genetics
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://orcid.org/0000-0003-1080-4339|https://orcid.org/0000-0002-1571-1468|https://frl.publisso.de/adhoc/uri/QXdhc3RoaSwgU3dhcG5pbA==|https://orcid.org/0000-0003-1067-5725|https://frl.publisso.de/adhoc/uri/SnVuZ2t1bnosIE1hcnRpbg==|https://orcid.org/0000-0003-4867-9465|https://orcid.org/0000-0002-9004-364X|https://orcid.org/0000-0003-1666-4701|https://orcid.org/0000-0002-3761-5215|https://frl.publisso.de/adhoc/uri/TWFzbGFoYXRpLCBUb2xvdQ==|https://frl.publisso.de/adhoc/uri/U2Nod2FyemUsIENvcm5lbGlhIEUu|https://frl.publisso.de/adhoc/uri/RGFobWVuLCBOb3JiZXJ0|https://orcid.org/0000-0002-8237-4481|https://frl.publisso.de/adhoc/uri/S2xlaW5kaWVuc3QsIE5pa29sYXVz|https://frl.publisso.de/adhoc/uri/SGFydG1hbm4sIEFubmV0dGU=|https://frl.publisso.de/adhoc/uri/R2llZ2xpbmcsIEluYQ==|https://frl.publisso.de/adhoc/uri/WmlsbGljaCwgTGVh|https://orcid.org/0000-0002-7989-5833|https://frl.publisso.de/adhoc/uri/UG9pc2VsLCBFcmlj|https://frl.publisso.de/adhoc/uri/Q2hlbiwgQ2hpLUh1YQ==|https://orcid.org/0000-0002-8770-2464|https://frl.publisso.de/adhoc/uri/TW9iYXNjaGVyLCBBcmlhbg==|https://orcid.org/0000-0002-1432-313X|https://frl.publisso.de/adhoc/uri/TGllYiwgS2xhdXM=|https://frl.publisso.de/adhoc/uri/Um9lcGtlLCBTdGVmYW4=|https://frl.publisso.de/adhoc/uri/U2NobWFobCwgQ2hyaXN0aWFu|https://frl.publisso.de/adhoc/uri/Qm9odXMsIE1hcnRpbg==|https://frl.publisso.de/adhoc/uri/Umlwa2UsIFN0ZXBoYW4=|https://orcid.org/0000-0002-5236-6149|https://orcid.org/0000-0002-4461-3568
1000 Label
1000 Förderer
  1. National Institutes of Health |
  2. Bundesministerium für Bildung und Forschung |
  3. Norges Forskningsråd |
  4. Projekt DEAL |
1000 Fördernummer
  1. R01MH118281
  2. 01EW1810; 01EW1904
  3. 229129; 213837; 223273
  4. -
1000 Förderprogramm
  1. -
  2. ERA-NET NEURON, “SynSchiz - Linking synaptic dysfunction to disease mechanisms in schizophrenia - a multilevel investigation“; ERA-NET NEURON “Impact of Early life MetaBolic and psychosocial strEss on susceptibility to mental Disorders; from converging epigenetic signatures to novel targets for therapeutic intervention”
  3. -
  4. Open Access funding
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer R01MH118281
  2. 1000 joinedFunding-child
    1000 Förderer Bundesministerium für Bildung und Forschung |
    1000 Förderprogramm ERA-NET NEURON, “SynSchiz - Linking synaptic dysfunction to disease mechanisms in schizophrenia - a multilevel investigation“; ERA-NET NEURON “Impact of Early life MetaBolic and psychosocial strEss on susceptibility to mental Disorders; from converging epigenetic signatures to novel targets for therapeutic intervention”
    1000 Fördernummer 01EW1810; 01EW1904
  3. 1000 joinedFunding-child
    1000 Förderer Norges Forskningsråd |
    1000 Förderprogramm -
    1000 Fördernummer 229129; 213837; 223273
  4. 1000 joinedFunding-child
    1000 Förderer Projekt DEAL |
    1000 Förderprogramm Open Access funding
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6434145.rdf
1000 Erstellt am 2022-07-13T10:34:46.494+0200
1000 Erstellt von 242
1000 beschreibt frl:6434145
1000 Bearbeitet von 317
1000 Zuletzt bearbeitet Mon Aug 01 07:51:12 CEST 2022
1000 Objekt bearb. Mon Aug 01 07:50:59 CEST 2022
1000 Vgl. frl:6434145
1000 Oai Id
  1. oai:frl.publisso.de:frl:6434145 |
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