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1000 Titel
  • Progressive reorganization of mitochondrial apparatus in aging skeletal muscle of naked mole rats (Heterocephalus glaber) as revealed by electron microscopy: potential role in continual maintenance of muscle activity
1000 Autor/in
  1. Vays, Valeriya |
  2. Vangely, Irina |
  3. Eldarov, Chupalav |
  4. Holtze, Susanne |
  5. Hildebrandt, Thomas |
  6. Bakeeva, Lora |
  7. Skulachev, Vladimir |
1000 Erscheinungsjahr 2021
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2021-11-28
1000 Erschienen in
1000 Quellenangabe
  • 13(22):24524-24541
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2021
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.18632/aging.203720 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The authors examined the ultrastructure of mitochondrial apparatus of skeletal muscles of naked mole rats (Heterocephalus glaber) from the age of 6 months to 11 years. The obtained results have demonstrated that the mitochondria in skeletal muscles of naked mole rats aged below 5 years is not well-developed and represented by few separate small mitochondria. Mitochondrial reticulum is absent. Starting from the age of 5 years, a powerful mitochondrial structure is developed. By the age of 11 years, it become obvious that the mitochondrial apparatus formed differs from that in the skeletal muscle of adult rats and mice, but resembles that of cardiomyocytes of rats or naked mole rats cardiomyocytes. From the age of 6 months to 11 years, percentage area of mitochondria in the skeletal muscle of naked mole rat is increasing by five times. The growth of mitochondria is mainly driven by increased number of organelles. Such significant growth of mitochondria is not associated with any abnormal changes in mitochondrial ultrastructure. We suppose that specific structure of mitochondrial apparatus developed in the skeletal muscle of naked mole rats by the age of 11 years is necessary for continual skeletal muscle activity of these small mammals burrowing very long holes in stony earth, resembling continual activity of heart muscle. In any case, ontogenesis of naked mole rat skeletal muscles is much slower than of rats and mice (one more example of neoteny).
1000 Sacherschließung
lokal mitochondria
lokal naked mole-rat
lokal neoteny
lokal aging
lokal electron microscopy
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/VmF5cywgVmFsZXJpeWEg|https://frl.publisso.de/adhoc/uri/VmFuZ2VseSwgSXJpbmE=|https://frl.publisso.de/adhoc/uri/RWxkYXJvdiwgQ2h1cGFsYXYg|https://frl.publisso.de/adhoc/uri/SG9sdHplLCBTdXNhbm5l|https://frl.publisso.de/adhoc/uri/SGlsZGVicmFuZHQsIFRob21hcw==|https://frl.publisso.de/adhoc/uri/QmFrZWV2YSwgTG9yYQ==|https://frl.publisso.de/adhoc/uri/U2t1bGFjaGV2LCBWbGFkaW1pcg==
1000 Label
1000 Förderer
  1. Russian Foundation of Basic Research |
1000 Fördernummer
  1. 19-04-00578
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Russian Foundation of Basic Research |
    1000 Förderprogramm -
    1000 Fördernummer 19-04-00578
1000 Objektart article
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1000 @id frl:6434356.rdf
1000 Erstellt am 2022-08-01T10:00:56.083+0200
1000 Erstellt von 317
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1000 Zuletzt bearbeitet 2022-08-05T16:06:39.351+0200
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1000 Oai Id
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